Preheparin serum lipoprotein lipase mass level: the effects of age, gender, and types of hyperlipidemias

Watanabe, Hitoshi; Miyashita, Yoh; Murano, Takeyoshi; Hiroh, Yuhji; Itoh, Yoshiaki; Shirai, Kohji

doi:10.1016/s0021-9150(99)00012-x

Cited by 68 publications

(61 citation statements)

References 23 publications

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“…Other group in Japan has reported similar results for 377 Japanese individuals who underwent annual health examinations [14].…”

Section: Relationship Of Serum Lpl Concentration With Lipoproteins Ansupporting

confidence: 65%

“…It has been reported that serum LPL mass had a positive relation with PHP-LPL mass [14,19,20], although the degree of the relation appeared to differ among the reports. It should be noted that Hirano et al [20] have shown that the delta LPL concentration was strongly related to the PHP-LPL concentration (r =.965, P </=.0001), but not to the serum LPL mass, suggesting that the weak correlation between serum LPL and PHP-LPL levels was attributable to contamination of PHP by pre-existing LPL.…”

Section: Correlation Of Serum Lpl To Post-heparin Plasma (Php) Lpl Massmentioning

confidence: 86%

“…From the last decade, however, several groups of researchers [12][13][14][15][16][17][18][19] have shown the clinical significance of measuring LPL protein mass in plasma or sera by an enzyme-linked immunosorbent assay (ELISA) without heparin injection (simply put as serum or plasma LPL mass). In earlier studies, researchers applied the measurement of plasma or serum LPL mass to detailed analysis and characterization of type 1 hyperlipidemia (HLP) [16,17].…”

Section: Introductionmentioning

confidence: 99%

“…Tornvall et al [13,15] have studied the correlation between lipoproteins and plasma LPL mass from men before the age of 45 years with coronary heart disease and from age-matched controls, and found that there was a strong positive correlation between plasma LPL mass and HDL-C levels as well as weak negative relations to VLDL-TG in the patients. The study by Watanabe et al [14] has shown that serum LPL mass is lower in conditions in which TG catabolism is disturbed, such as hypertriglyceridemia and individuals with increased remnant lipoproteins.…”

Section: Introductionmentioning

confidence: 99%

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Serum lipoprotein lipase mass: Clinical significance of its measurement

Kobayashi

Nohara

Kawashiri

et al. 2007

Clinica Chimica Acta

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“…Other group in Japan has reported similar results for 377 Japanese individuals who underwent annual health examinations [14].…”

Section: Relationship Of Serum Lpl Concentration With Lipoproteins Ansupporting

confidence: 65%

Section: Correlation Of Serum Lpl To Post-heparin Plasma (Php) Lpl Massmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Serum lipoprotein lipase mass: Clinical significance of its measurement

Kobayashi

Nohara

Kawashiri

et al. 2007

Clinica Chimica Acta

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“…Over the last decade, several studies showed that LPL mass in non-heparinized serum (LPLm) was a useful, physiologically relevant index of LPL-mediated lipolysis of plasma triacylglycerol (TG), because of low concentrations in LPL-deficient patients (Kern et al, 1990;Kobayashi et al, 1993) and significant relationships between serum LPLm, lipids, lipoproteins, and insulin resistance (Kobayashi et al, 1993(Kobayashi et al, , 2007Tornvall et al, 1995;Watanabe et al, 1999;Hanyu et al, 2007;Saiki et al, 2007). The aim of this study is to know the influence of LPL on neonatal subcutaneous fat growth.…”

Section: Introductionmentioning

confidence: 99%

Association between serum lipoprotein lipase mass concentration and subcutaneous fat accumulation during neonatal period

et al. 2010

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Background/Objectives: Subcutaneous adipose tissue grows rapidly during the first months of life. Lipoprotein lipase (LPL) has a quantitatively important function in adipose tissue fat accumulation and insulin-like growth factor-I (IGF-I) is a determinant of neonatal growth. Recent studies showed that LPL mass in non-heparinized serum (LPLm) was an index of LPL-mediated lipolysis of plasma triacylglycerol (TG). The objective was to know the influence of serum LPL and IGF-I on neonatal subcutaneous fat growth, especially on catch-up growth in low birth weight infants. Subjects/Methods: We included 47 healthy neonates (30 males, 17 females), including 7 small for gestational age. We measured serum LPLm and IGF-I concentrations at birth and 1 month, and analyzed those associations with subcutaneous fat accumulation. Results: Serum LPLm and IGF-I concentrations increased markedly during the first month, and positively correlated with the sum of skinfold thicknesses both at birth (r ¼ 0.573, P ¼ 0.0001; r ¼ 0.457, P ¼ 0.0035) and at 1 month (r ¼ 0.614, Po0.0001; r ¼ 0.787, Po0.0001, respectively). In addition, serum LPLm concentrations correlated inversely to very low-density lipoprotein (VLDL)-TG levels (r ¼ À0.692, Po0.0001 at birth; r ¼ À0.429, P ¼ 0.0052 at 1 month). Moreover, the birth weight Z-score had an inverse association with the postnatal changes in individual serum LPLm concentrations (r ¼ À0.639, Po0.0001). Conclusions: Both serum LPLm and IGF-I concentrations were the determinants of subcutaneous fat accumulation during the fetal and neonatal periods. During this time, LPL-mediated lipolysis of VLDL-TG may be one of the major mechanisms of rapid growth in subcutaneous fat tissue. Moreover, LPL, as well as IGF-I, may contribute to catch-up growth in smaller neonates.

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