Preimplantation exposure to bisphenol A advances postnatal development

Takai, Yasushi; Tsutsumi, Osamu; Ikezuki, Yumiko; Kamei, Yoshimasa; Osuga, Yutaka; Yano, Tetsu; Taketan, Yuji

doi:10.1016/s0890-6238(00)00119-2

Cited by 133 publications

(81 citation statements)

References 22 publications

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“…BPA contamination levels in the present study were the same as found in the environment such as in river water [9]. BPA contamination in both humans and environment may be significant because BPA effects in in vitro experiment were found to be less than these concentrations [17].…”

Section: Discussionsupporting

confidence: 70%

“…BPA has been shown to have several actions such as uterotrophic effects [12,13], decreasing sperm production [14], stimulation of prolactin release [15], and promotion of cell proliferation in a breast cancer cell line [7], by animal experiments. It was reported to have a promotive effect on growth and puberty by fetal or preimplantation exposure of environmental doses of BPA in mouse [16,17]. To study human contamination of BPA, we employed enzyme-linked immunosorbent assay (ELISA) and reported that BPA was detectable not only in the serum but several biological fluids including amniotic fluids demonstrating human fetal exposure to BPA through placenta [18].…”

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confidence: 99%

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Differences in Serum Bisphenol A Concentrations in Premenopausal Normal Women and Women with Endometrial Hyperplasia

et al. 2004

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Abstract. Exposure to endocrine disrupting chemicals (EDCs) has been raised in relation to its potential for adverse health outcomes. Bisphenol A (BPA) is an estrogenic EDC widely found in plastic products. We determined BPA concentrations in premenopausal women by an enzyme-linked immunosorbent assay and evaluated possible linkage between its contamination levels and endometrial hyperplasia, an estrogen-related disorder of the uterus. It has been implied that higher levels of BPA, which binds to estrogen receptor and plays estrogenic roles may, enhance endometrial hyperplasia. Serum BPA was detectable in all subjects and its concentrations in healthy controls with normal endometrium were 2.5 ± 1.5 ng/ml (mean ± SD). BPA levels in patients with simple endometrial hyperplasia with benign nature were 2.9 ± 2.0 ng/ml and were not significantly different from the controls. Unexpectedly, BPA levels in patients with complex endometrial hyperplasia with malignant potential were 1.4 ± 0.4 ng/ml and significantly lower compared to both control and simple endometrial hyperplasia groups. In addition, we measured the serum BPA levels in postmenopausal endometrial cancer patient (1.4 ± 0.5 ng/ml), which were also significantly lower than control and simple endometrial hyperplasia groups. These findings suggest the presence of associations between BPA exposure and complex endometrial hyperplasia and endometrial cancer. The mode of action of BPA may be more complex than expected and the contradictory results may serve as a clue to addressing the mechanisms of linkage between occurrence of estrogendependent diseases and endocrine disruption.

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Section: Discussionsupporting

confidence: 70%

mentioning

confidence: 99%

Differences in Serum Bisphenol A Concentrations in Premenopausal Normal Women and Women with Endometrial Hyperplasia

et al. 2004

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“…BPA has been shown to exhibit several actions, such as uterotrophic effects [9], decreasing sperm production [10], stimulation of prolactin release [11], promotion of cell proliferation in a breast cancer cell line [5], and influencing preimplantation development [12], in animal experiments. Promotion of growth and puberty by fetal or preimplantation exposure to BPA in mice has been reported [13,14]. We reported that BPA was detectable not only in the serum but also in several biological fluids, including amniotic fluid, demonstrating human fetal exposure to BPA through the placenta [15].…”

mentioning

confidence: 73%

Elevated Serum Bisphenol A Levels under Hyperandrogenic Conditions may be Caused by Decreased UDP-glucuronosyltransferase Activity

et al. 2006

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Abstract. This study was performed to investigate the effect of androgen on the metabolism of bisphenol A (BPA), an endocrine disruptor, in order to clarify the mechanism of the higher levels of serum BPA in men and hyperandrogenemic women compared with normal women. Castrated female rats (OVX) were subcutaneously injected with testosterone propionate (TP) (0.01, 0.1, and 1 mg) every day for 2 weeks. Serum BPA concentrations in OVX rats showed a TP dosedependent increase and were significantly higher at 0.1 and 1.0 mg of TP. The enzyme reaction of BPA glucuronidation in the rat liver microsomes showed that the ratio of glucuronide in the OVX rats was significantly reduced in a TP dosedependent manner. Analysis of the mRNA expression of UDP-glucuronosyltransferase 2B1 (UGT2B1) by real-time quantitative RT-PCR revealed that the relative expression level of UGT2B1 mRNA showed a TP dose-dependent decrease. The results of enzyme analyses demonstrated that the ratio of BPA glucuronidation and the expression level of UGT2B1 mRNA were significantly lower under the hyperandrogenemic conditions. The clearance of BPA may be slowed in a TP dose-dependent manner, resulting in an increase of serum BPA concentration under hyperandrogenemic conditions.

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“…Jurisicova et al (1996) investigated the association between expression in human embryos and factors known to influence in vitro fertilization pregnancy outcomes. Takai et al (2000) explained how prenatal exposure to an estrogenic compound alters postnatal development. Cervero et al (2004) studied body weight and reproductive function during human embryonic preimplantation development.…”

Section: Discussionmentioning

confidence: 99%

A note on interaction and pre-implantation development stages

Chimka¹,

Jiang²

2014

J. Cell Anim. Biol.

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Having obtained observations of gene expression profiles from the literature, we estimated autoregressive models of mouse preimplantation development and observed interaction among stages. Gene expression profile at the earliest stage is not generally significant, but for observations where profiles at 8-cell embryo and morula stages are relatively great, the effect of unfertilized egg is significantly positive.

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Preimplantation exposure to bisphenol A advances postnatal development

Cited by 133 publications

References 22 publications

Differences in Serum Bisphenol A Concentrations in Premenopausal Normal Women and Women with Endometrial Hyperplasia

Differences in Serum Bisphenol A Concentrations in Premenopausal Normal Women and Women with Endometrial Hyperplasia

Elevated Serum Bisphenol A Levels under Hyperandrogenic Conditions may be Caused by Decreased UDP-glucuronosyltransferase Activity

A note on interaction and pre-implantation development stages

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