Preischemic neuroprotective effect of minocycline and sodium ozagrel on transient cerebral ischemic rat model

Park, Sang‐In; Park, Soo Young; Jang, Kyung-Sool; Han, Yong; Kim, Choong Hyeon; Oh, Seok Jeon

doi:10.1016/j.brainres.2014.12.051

Cited by 22 publications

(11 citation statements)

References 26 publications

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“…Our study showed that MIN significantly alleviated neuronal degeneration in both the hippocampus and cerebellum, 41 showed that pretreatment of SD rats with MIN 10 leads to a smaller infarct volume and a higher number of NeuN+ neurons in a transient cerebral ischemia model. Orazizadeh et al 22 showed that MIN inhibits dexamethasone-induced germ cell apoptosis in the testes of mice.…”

Section: Discussionmentioning

confidence: 51%

Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats

et al. 2020

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This study investigated the protective effects of minocycline against acrylamide (ACR)-induced neurotoxicity and testicular damage in Sprague-Dawley rats. Forty rats were divided into five groups (eight rats each). Group I received saline (0.5 mL/rat) daily for 10 days and served as the untreated control group. Group II received ACR (30 mg/kg body weight (b.w.)) daily for 10 days. Group III received ACR (30 mg/kg b.w.) daily for 10 days and subsequently minocycline (60 mg/kg b.w.) for five days. Group IV received ACR (30 mg/kg b.w.) daily for 10 days followed by saline for five days and served as the control group for the ACR-minocycline-treated group. Group V received minocycline (60 mg/kg b.w.) for five days. All treatments were administered orally. Rats in group I and V showed normal locomotor behavior and normal histology of the brain and testes. Administration of ACR (Group II and IV) resulted in weight loss and gait abnormalities. Furthermore, neuronal degeneration in the hippocampus and cerebellum and degeneration of the seminiferous tubular epithelium with formation of spermatid giant cells were observed. Ultrastructurally, ACR specifically damaged spermatogonia and spermatocytes. Acrylamide was also seen to cause a significant increase of malondialdehyde levels in the brain and testes. Treatment of ACR-administered rats with minocycline (Group III) significantly alleviated the loss of body weight and improved locomotor function. Minocycline also ameliorated neuronal degeneration and seminiferous tubular damage and decreased malondialdehyde concentrations. In conclusion, minocycline protects against neurotoxic effects of acrylamide and seminiferous tubular damage. Decreasing lipid peroxidation by minocycline might play a role in such protection.

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Section: Discussionmentioning

confidence: 51%

Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats

et al. 2020

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“…One Japanese study found that ozagrel did not increase the risk of hemorrhagic complications in patients with atherothrombotic stroke or lacunar infarction; however, it did not significantly improve functional outcomes (26). Another study showed that ozagrel and argatroban had similar efficacies in the treatment of acute non-cardioembolic stroke, regardless of the use of edaravone (27); further, in an animal study, the authors found that pretreatment with ozagrel may show neuroprotective effects in rats with stroke (28). However, there is little information regarding the application of ozagrel for treating stroke, indicating a clear need for further evaluations of its application in the treatment of ischemic stroke.…”

Section: ' Discussionmentioning

confidence: 99%

Statistical analysis for efficacy of tirofiban combined with ozagrel in the treatment of progressive cerebral infarction patients out of thrombolytic therapy time window

Zhang¹,

Zheng²

2021

Clinics

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“… ( Soliman et al, 2015 ) tMCAO (30′) Rat I.V, 30′ before 7 days Adhesive removal test, 1 and 7 days Decreased infarct volume, improved neurobehavioral functions. ( Park et al, 2015 ) tBCCAO (20′) Rat I.P, once per day up to 7 No Morris water-maze 7 days Improved memory, enhanced neuronal viability. ( Naderi et al, 2017 ) Photothromb.…”

Section: Experimental Basis For the Clinical Trials On Immunomodulatomentioning

confidence: 99%

Filling the gaps on stroke research: Focus on inflammation and immunity

Levard

Buendía

Lanquetin

et al. 2021

Brain, Behavior, and Immunity

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Highlights The different experimental approaches may model different aspects of stroke. Drugs need to be tested in several clinically relevant experimental stroke models. Clot composition, type of arterial occlusion and recanalization need to be considered. Outcomes should include acute but also long-term measurements. Both infarct volume and behavioral deficits need to be systematically measured. Including coexisting risk factors in preclinical stroke research is mandatory. Performing multicenter studies may increase the reliability of preclinical results.

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Preischemic neuroprotective effect of minocycline and sodium ozagrel on transient cerebral ischemic rat model

Cited by 22 publications

References 26 publications

Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats

Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats

Statistical analysis for efficacy of tirofiban combined with ozagrel in the treatment of progressive cerebral infarction patients out of thrombolytic therapy time window

Filling the gaps on stroke research: Focus on inflammation and immunity

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