Preliminar Study of the Effects of Gamma Radiations on Human Red Blood Cells

Abstract

In this study, the alterations in viscoelastic and aggregation parameters of red blood cells were analyzed for usual gamma irradiation procedures for transfusion purposes. In order to determine possible hemorheological changes that may affect the health of patients and their relationship with the biochemical changes observed, the blood samples were irradiated at different doses. The results show alterations in the erythrocyte aggregation time, in the membrane surface viscosity and in the size of the aggregates in the irradiated samples, suggesting that the damage produced by the ionizing radiation affects the physical properties of red blood cell membrane at different levels.

Preliminary Study of the Gamma-Radiation Effect on the Plasma Ions Concentration in Transfusion Units

“…La bomba de Na + /K + desempeña un papel muy importante en el mantenimiento del volumen celular, iguala la presión osmótica a ambos lados de la membrana y mantiene el potencial de membrana. Se ha visto, además, que la irradiación promueve la generación de especies reactivas del oxígeno y la peroxidación de lípidos de la membrana de los glóbulos rojos [3], incrementa la ©2024 Anales AFA permeabilidad de la membrana eritrocitaria al potasio, sodio y hemoglobina, y disminuye su deformabilidad [4][5][6][7][8]. Todos estos efectos sobre los glóbulos rojos reducen la viabilidad transfusional de las unidades irradiadas almacenadas disminuyendo su viabilidad de 42 a 28 días [9].…”