Preliminary analysis of the behavior of stage I ovarian serous tumors of low malignant potential: a Gynecologic Oncology Group study.

Barnhill, Danny; Kurman, Robert J.; Brady, M. F.; Omura, George; Yordan, Edgardo; Given, Fred T.; Kucera, Paul R.; Roman, L.

doi:10.1200/jco.1995.13.11.2752

Cited by 148 publications

(66 citation statements)

References 13 publications

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“…Microscopically, cells formed 3 or less layers with or without papillae over a continuous extent of at least 5mm. 4,21,22 Out of 6 cases, 5 cases were more than 40 years age and one case was below 40 years, all were unilateral and four cases were of size more than 10cms. In our study, three cases showed endocervical type of lining epithelium ( fig.2).…”

Section: Borderline Epithelial Tumorsmentioning

confidence: 99%

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Surface epithelial tumors of ovary - an analysis in a tertiary referral hospital

Ghartimagar

Ghosh

et al. 2013

J Pathol Nep

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Background: Ovarian cancer accounts for 3% of all cancers in females. About 80% of these are benign, and they occur mostly in young women between 20 and 45 years. Borderline tumors occur at slightly older ages while incidence of malignant tumors increases with age, occurring predominantly in perimenopausal and postmenopausal women. About 190,000 new cases and 114,000 deaths from ovarian cancer are estimated to occur annually worldwide. The aim of the study was to fi nd the incidence of surface ovarian tumor in a tertiary referral centre. Materials and methods: This was a retrospective study carried out in the department of pathology, Manipal Teaching Hospital from January 2001 to December 2012. Specimens were received from the same and other hospitals. Records were retrieved from the departmental data bank and were analyzed. Results: : A total of 310 cases of ovarian tumors have been reported in the same period. Among them, 180 cases were of surface epithelial origin and out of which 24 cases had bilateral tumors. Benign tumors comprised of 148 cases, 6 were borderline and 44 were malignant. Among these, the commonest was serous cystadenoma (98 cases) and the least common was malignant Brenner (2 cases). Combined or mixed tumor was seen in 9 cases. Conclusion: : In our study surface epithelial tumors comprised 58% of all ovarian tumors. In both benign and malignant cases, serous tumor was the commonest followed by mucinous tumors. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 397-402 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7868

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Section: Borderline Epithelial Tumorsmentioning

confidence: 99%

“…13 We had 44 cases of carcinomas comprising 22.2% of all surface tumors.The mean age was 43.23 years and almost the same age incidence (42 to 48) is reported in other studies as well. 11,21,[23][24][25] .…”

Section: Malignant Epithelial Tumorsmentioning

confidence: 99%

Surface epithelial tumors of ovary - an analysis in a tertiary referral hospital

Ghartimagar

Ghosh

et al. 2013

J Pathol Nep

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“…234 In contrast to patients with frankly invasive ovarian carcinoma, women with borderline epithelial tumors tend to be younger, are often diagnosed with stage I disease, and are candidates for fertility-sparing surgery. 235,236 Borderline epithelial tumors are rare tumors and are managed differently from high-grade carcinomas (see LCOH-6; page 1141). 136,237 The characteristic pathologic hallmark of typical epithelial ovarian cancer is the identification of peritoneal implants, which microscopically and/or macroscopically invade the peritoneum.…”

Section: Borderline Epithelial Tumors (Low Malignant Potential Tumors)mentioning

confidence: 99%

“…Treatment: Surgery is the primary treatment for borderline epithelial tumors, including standard ovarian cancer debulking surgery or fertility-sparing surgery, depending on the surgical evaluation and other factors as discussed in the subsequent paragraphs (see "Principles of Surgery" in the complete version of these guidelines, available at NCCN.org [OV-A]). 238 Treatment guidelines for borderline epithelial tumors depend on the histologic and clinical characteristics, the age of the patient, 236 and whether invasive implants are present. Patients should be evaluated by a gynecologic oncologist.…”

Section: Borderline Epithelial Tumors (Low Malignant Potential Tumors)mentioning

confidence: 99%

Ovarian Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

Morgan

Armstrong

Alvarez

et al. 2016

J Natl Compr Canc Netw

307

233

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“…30,34 Ovarian cystectomy without oophorectomy is done for selected patients with Stage I lesions if the tumor is loosely attached and complete removal can be accomplished. 75 The approach to high-stage disease is less uniform. Generally, surgical debulking of tumor with thorough microscopic examination of implants to detect invasion is done.…”

Section: Treatmentmentioning

confidence: 99%

Borderline epithelial tumors of the ovary

2005

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The concept and terminology of borderline epithelial tumors of the ovary have been controversial for over a century, in spite of the acceptance of a borderline category in almost all current classifications of ovarian tumors. Typically, borderline tumors are noninvasive neoplasms that have nuclear abnormalities and mitotic activity intermediate between benign and malignant tumors of similar cell type. Borderline tumors of all surface epithelial cell types have been studied. The most common and best understood are serous borderline tumors and mucinous borderline tumors of intestinal type, which are the subject of this review. Some of the most challenging issues for serous tumors include: the criteria and clinical behavior of stromal microinvasion; the high prevalence of synchronous extraovarian disease; the classification and histopathologic features of associated peritoneal tumor implants, especially invasive implants; and, the prognostic significance of micropapillary tumors. The mucinous borderline tumors of intestinal type have a different set of considerations, including: their frequently heterogeneous composition with coexisting benign, borderline and malignant elements; the classification and significance of accompanying noninvasive carcinoma; the recognition of stromal invasion, including microinvasion and expansile invasion; and, the historically misunderstood relationship to pseudomyxoma peritonei. All of these issues are discussed in this presentation, as are the important gross and microscopic features of serous and mucinous borderline tumors and pertinent information on their treatment and prognosis. Modern Pathology (2005) 18, S33-S50.

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Preliminary analysis of the behavior of stage I ovarian serous tumors of low malignant potential: a Gynecologic Oncology Group study.

Abstract: Stage I ovarian serous LMP tumors rarely, if ever, recur. Limited resection, after meticulous surgical exploration, is adequate therapy for women of reproductive age.

Cited by 148 publications

References 13 publications

Surface epithelial tumors of ovary - an analysis in a tertiary referral hospital

Surface epithelial tumors of ovary - an analysis in a tertiary referral hospital

Ovarian Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

Borderline epithelial tumors of the ovary

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