Preliminary chronic toxicity study of copper aspirinate

Sorenson, John R. J.; Rolniak, Thomas M.; Chang, Louis W.

doi:10.1016/s0020-1693(00)81781-8

Cited by 12 publications

(3 citation statements)

References 2 publications

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“…Kaolin paw oedema was induced, by a reported literature method 11 in male Wistar rats weighing 95 -115 g, in groups of five animals. The complexes under investigation were administered orally in 5% Mulgophen (GAF, Manchester) in distilled water (0.2 ml per 100 g) 1 h before the kaolin oedema induction.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Transition Metal Acetylsalicylates and Their Anti-inflammatory Activity

Chohan

Iqbal

et al. 2002

Journal of Enzyme Inhibition and Medicinal Chemistry

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Transition Metal Acetylsalicylates and Their Anti-inflammatory Activity

Chohan

Iqbal

et al. 2002

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Although a previous study reported the high accumulation of copper in the livers of rats accompanied by reduction in the concentration of iron in different organs after 22 days of treatment with highdose CuAsp, 40 the preliminary chronic toxicity study of CuAsp 41 found no remarkable histopathological changes in various rat tissues after 3 months of CuAsp treatment, with the exception of an increase of phagocytic Kupffer cells in the liver. Thus, further detailed toxicological investigations are needed.…”

Section: Limitationsmentioning

confidence: 82%

Improvement of Aging-Associated Cardiovascular Dysfunction by the Orally Administered Copper(II)-Aspirinate Complex

Radovits

Gerö

et al. 2008

Rejuvenation Research

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Background: Aging-associated nitro-oxidative stress causes tissue injury and activates proinflammatory pathways that play an important role in the pathogenesis of aging-associated cardiovascular dysfunction. It has been recently reported, that the copper(II)-aspirinate complex (CuAsp) exerts not only the well-known anti-inflammatory and platelet antiaggregating effects of aspirin, but, due to its superoxide dismutase mimetic activity, it acts as a potent antioxidant as well. In this study we investigated the effects of CuAsp on aging-associated myocardial and endothelial dysfunction. Methods and Results: Aging and young rats were treated for 3 weeks with vehicle, or with CuAsp (200 mg/kg per day per os). Left ventricular pressure-volume relations were measured by using a microtip pressure-volume conductance catheter, and indexes of contractility (e.g., slope of end-systolic pressure-volume relationships [ESPVR] [E es ], and dP/dt max Ϫ end-diastolic volume [EDV]) were calculated. In organ bath experiments for isometric tension with isolated aortic rings, endothelium-dependent and -independent vasorelaxation were investigated by using acetylcholine and sodium nitroprusside. When compared to the young controls, aging rats showed impaired left ventricular contractility (E es , 0.51 Ϯ 0.04 vs. Conclusions: Our results demonstrate that oxidative stress and inflammatory pathways contribute to the pathogenesis of cardiovascular dysfunction in the aging organism, which can be reversed by CuAsp.

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“…Since 1976 when Professor J.R.J. Sorensen first suggested that the active form of this drug is a copper complex formed in vivo, the copper complex of aspirin, copper aspirinate, has been proven by many researchers to be more effective as an anti-inflammatory agent and less toxic than aspirin [1,2]. However, whether the complex is more active as an anti-platelet aggregation agent remained an open question.…”

Section: Introductionmentioning

confidence: 99%

Coordination of copper with aspirin enhances its anti-platelet aggregation activity

et al. 1997

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Anti-platelet aggregation of copper aspirinate, a copper complex of aspirin, has been studied in vitro and in vivo. The result shows that copper aspirinate is much more effective than aspirin against AA-, ADP- and PAF-induced platelet aggregation. Its mechanism is related to the inhibition of platelet cyclooxygenase and release of active substances from platelets, and to the promotion of PGI(2) level in plasma.

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Preliminary chronic toxicity study of copper aspirinate

Cited by 12 publications

References 2 publications

Transition Metal Acetylsalicylates and Their Anti-inflammatory Activity

Transition Metal Acetylsalicylates and Their Anti-inflammatory Activity

Improvement of Aging-Associated Cardiovascular Dysfunction by the Orally Administered Copper(II)-Aspirinate Complex

Coordination of copper with aspirin enhances its anti-platelet aggregation activity

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