Preliminary clinical application of foldable capsular vitreous body in severe silicone oil-dependent eyes

Abstract

Background: To investigate the clinical safety and efficacy of foldable capsular vitreous body (FCVB) in the treatment of severe silicone oil-dependent eyes.Methods: Five patients (5 eyes) of severe silicone oil-dependent eyes underwent FCVB implantation from December 2019 to July 2020. The preoperative and postoperative visual acuity, intraocular pressure, corneal conditions, postoperative retinal reattachment, and FCVB status were observed. The patients were followed up for 12-15 months.Results: A total of 5 patients (5 eyes) with severe silicone oil-dependent eyes were included, including 3 males and 2 females, with an average age of 32±14 years. The longest silicone oil tamponade time was 8 years, and the shortest was 2 years, with an average of 5±3 years. All patients were safely and successfully implanted with FCVB without severe intraoperative or postoperative complications. Up to the last followup, there was no significant change between preoperative and postoperative visual acuity. Before surgery, 4 patients had normal intraocular pressure while 1 patient had ocular hypotension; after surgery, the latter was still at a low level, and the other patients had intraocular pressure in the normal range. Conclusions:The FCVB is a safe, feasible, and effective vitreous substitute to maintain ocular morphology and intraocular pressure without aggravating silicone oil emulsification, retinal displacement, or corneal degeneration during the implantation period of 12-15 months.

Foldable Capsular Vitreous Body Implantation for Complicated Retinal Detachment Caused by Severe Ocular Trauma

“…In these cases, another silicone oil filling operation must be performed, which we call silicone oil-dependent eyes. 6,10 Patients who have undergone one or more surgeries for complicated Fig. 3.…”

“…In these cases, another silicone oil filling operation must be performed, which we call silicone oil-dependent eyes. 6 , 10 Patients who have undergone one or more surgeries for complicated retinal detachment, especially those who have used silicone oil, are more likely to develop epiretinal proliferation, which will lead to the final failure of the operation. 11 Silicone oil will cause a toxic effect on ganglion cells and lead to visual deterioration.…”

“…Complications such as rejection, corneal degeneration, FCVB displacement, endophthalmitis, secondary glaucoma, silicone oil emulsification, and strabismus did not occur during the follow-up period in this study, which indicates that it is safe for FCVB implantation and is similar to previous research results. 6 …”

“…Foldable capsular vitreous body (FCVB) uses a modified polysiloxane elastomer as the basic material for preparing film pouches; the material becomes elastically deformed; has good tensile, physical, and mechanical properties; and low hardness. 5 Compared with the direct injection of silicone oil into the vitreous cavity, FCVB avoids the direct contact of silicone oil with the intraocular tissues, 6 which prolongs the retention time in the eye, reduces related complications caused by silicone oil, and does not require a second oil extraction operation. As a result, FCVB can be placed in the eye for a long time.…”

Evaluation of Foldable Capsular Vitreous Body Implantation Surgery

“… Deng J et al 30 2021 26 Ocular rupture; SO-dependent eyes; 36.0(20–60) 23(26) 10 to 14 months Evaluated the long-term effect of foldable capsular vitreous body (FCVB) in the treatment of severe ocular rupture FCVB implantation is a long-term effective treatment for severe ocular rupture. Liu N et al 31 2021 5 SO-dependent eyes; 32.0(18–46) 3(5) 12 to 15 months Observed 5 patients of severe silicone oil-dependent eyes underwent FCVB implantation The FCVB is a safe, feasible, and effective vitreous substitute to maintain ocular morphology and intraocular pressure Xu X et al 5 2021 18 Ocular trauma; SO-dependent eyes 50.6(34–70) 17(18) 12 months Observed 18 patients who underwent vitrectomy and FCVB implantation for severe ocular trauma and silicone oil-dependent eyes FCVB implantation is an effective and safe treatment for eyes with severe ocular trauma and silicone oil-dependent eyes. Zhang Z et al 7 2021 27 RD; posterior trauma Air group:41.8±13.5 Viscoelastic group:42.4±14.2 Air group:10 (13) Viscoelastic group:11(14) 6 months To compare the outcomes of viscoelastic substance injection with air filling in the anterior chamber during FCVB implant surgery in patients with severe retinal disease.…”