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Background: To investigate the clinical safety and efficacy of foldable capsular vitreous body (FCVB) in the treatment of severe silicone oil-dependent eyes.Methods: Five patients (5 eyes) of severe silicone oil-dependent eyes underwent FCVB implantation from December 2019 to July 2020. The preoperative and postoperative visual acuity, intraocular pressure, corneal conditions, postoperative retinal reattachment, and FCVB status were observed. The patients were followed up for 12-15 months.Results: A total of 5 patients (5 eyes) with severe silicone oil-dependent eyes were included, including 3 males and 2 females, with an average age of 32±14 years. The longest silicone oil tamponade time was 8 years, and the shortest was 2 years, with an average of 5±3 years. All patients were safely and successfully implanted with FCVB without severe intraoperative or postoperative complications. Up to the last followup, there was no significant change between preoperative and postoperative visual acuity. Before surgery, 4 patients had normal intraocular pressure while 1 patient had ocular hypotension; after surgery, the latter was still at a low level, and the other patients had intraocular pressure in the normal range. Conclusions:The FCVB is a safe, feasible, and effective vitreous substitute to maintain ocular morphology and intraocular pressure without aggravating silicone oil emulsification, retinal displacement, or corneal degeneration during the implantation period of 12-15 months.

Background: Although observational studies have suggested that prior intravitreal therapy may predict posterior capsule rupture (PCR) during cataract surgery, this finding is still controversial. Objective: To summarize current evidence on the association between prior intravitreal injection (IVI) and PCR during cataract surgery. Methods: A systematic literature search was performed up to October 27th, 2021. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random-effects models. The potential association between IVI and PCR in future cataract surgeries was assessed using the following two models: “pooling the odds ratios of PCR in eyes with and without previous IVI(s)” and “pooling the odds ratios for PCR relative to each increase in the number of prior injections.” The quality of included studies was appraised using the Newcastle-Ottawa Scale. Results: 6 cohort studies were included in this meta-analysis, with a total of 1,051,097 eyes that underwent cataract surgery. Of these, 7,034 eyes were associated with previous IVI. The pooled odds of PCR in eyes with prior IVI was 2.01 (95% CI: 1.35–3.00) times higher than that of eyes without an IVI history. An increase in the number of previous IVI conferred increased odds of PCR of 1.03 (95% CI: 1.01–1.06). After excluding studies that failed to account for confounders, the significantly increased risk was not altered, and the significant heterogeneity was minimized in both models. Conclusion: This meta-analysis provides evidence that previous IVI significantly increases the risk of PCR during future cataract surgery. The risk of PCR should be discussed preoperatively with patients. Further studies are required to validate our findings and explore the underlying mechanisms.

The meta-analysis indicates that CYP2C9 and CYP2C19 polymorphisms are associated with lower PHT maintenance dosage in Asian epileptic patients. Ethnic differences can influence PHT maintenance dose.
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