Preliminary clinical diagnostic criteria for chronic traumatic encephalopathy: A case report and literature review

Non-Targeted Metabolomics Approach Revealed Significant Changes in Metabolic Pathways in Patients with Chronic Traumatic Encephalopathy

“…CTE is undoubtedly a distinct neurodegenerative disease, but many aspects of it, especially the pathophysiology of the disease, are not yet fully understood and clearly defined [ 33 ]. Consequently, despite many efforts [ 12 , 13 , 14 , 15 , 16 ], there is still a lack of validated biomarkers to detect and diagnose CTE during life, impeding subsequent discovery of treatment and prevention of CTE [ 34 ]. We, therefore, employed LC-MS to identify metabolic profiles from the postmortem brain of CTE patients and control subjects in hopes to provide new insights into the pathophysiology of CTE.…”

“…Though many studies recognized CTE as a distinct disease [ 5 , 9 , 11 ], distinguishing it from relatively well-understood neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), it is still a major diagnostic challenge. Many efforts have been devoted to diagnosing CTE in a living person by observing structural and physiological changes via neuroimaging techniques, namely magnetic resonance imaging (MRI), positron emission tomography (PET), and flortaucipir (FTP) [ 12 , 13 , 14 , 15 , 16 ]. However, not only does the significance of the findings of CTE remain to be elucidated since most studies focus on traumatic brain injury (TBI) rather than CTE [ 13 , 14 ], the imaging technologies also lack specificity and sensitivity for diagnosing CTE in a living person [ 12 ].…”

“…Many efforts have been devoted to diagnosing CTE in a living person by observing structural and physiological changes via neuroimaging techniques, namely magnetic resonance imaging (MRI), positron emission tomography (PET), and flortaucipir (FTP) [ 12 , 13 , 14 , 15 , 16 ]. However, not only does the significance of the findings of CTE remain to be elucidated since most studies focus on traumatic brain injury (TBI) rather than CTE [ 13 , 14 ], the imaging technologies also lack specificity and sensitivity for diagnosing CTE in a living person [ 12 ].…”