Preliminary Clinical Effect Evaluation of Resveratrol in Adults with Allergic Rhinitis

Abstract

Background: Resveratrol is a natural, nonflavonoid polyphenol, exerting anti-inflammatory activity. It has been reported that resveratrol, together with carboxymethyl-β-glucan, can reduce nasal symptoms in children with allergic rhinitis (AR). In this study, the effect of resveratrol on nasal symptoms in adults with AR was investigated. Methods: We conducted a placebo-controlled, double-blinded study. One hundred and fifty-one adults (aged 18–60 years) with severe persistent AR were divided into a placebo-treated group (n = 50), a positive control budesonide-treated group (n = 50), and a resveratrol-treated group (n = 51). They were then treated with 2 sprays (100 µL/spray) in each nostril 3 times/day for 1 month. Nasal symptoms including obstruction, itching, sneezing, and rhinorrhea, and the levels of IgE, IL-4, TNF-α, and eosinophils in the blood were assessed at baseline and after treatment. Results: Adults treated with resveratrol or budesonide achieved a significant reduction in nasal symptoms compared to the placebo-treated group. The resveratrol treatment significantly decreased the IgE, IL-4, TNF-α, and eosinophil levels in the blood. In addition, the resveratrol treatment was found to improve the quality of life of adults with AR. Conclusion: Our preliminary study showed that intranasal resveratrol is capable of significantly improving nasal symptoms in adults with AR.

Anti-allergic and anti-inflammatory effects of resveratrol via inhibiting TXNIP-oxidative stress pathway in a mouse model of allergic rhinitis

“… 22 , 23 In addition, intranasal resveratrol is effective for improving nasal symptoms in adults and children with AR. 24 , 25 Nonetheless, its precise role and mechanism in AR are still undetermined.…”

The effectiveness of thunder fire moxibustion for treating allergic rhinitis

“…[ 29 ] Topical intranasal glucocorticoids are the most commonly used treatment for moderate and severe AR in western medicine. [ 30 ] However, the long-term use of glucocorticoids can lead to nasal dryness, nosebleed and other adverse reactions, and the incidence of which can be as high as 20%. [ 31 ] Moreover, western medicine treatment is not effective for certain patients with moderate to severe AR.…”

Effectiveness and safety of indirect moxibustion for the treatment of allergic rhinitis

“…[ 33 ] Topical intranasal glucocorticoids are the most commonly used therapy for moderate and severe AR in Western medicine. [ 34 ] However, prolonged use of glucocorticoids can cause serious side effects, such as nasal dryness and nosebleed, and the incidence can be as high as 20%. [ 35 ] Moreover, Western medicine is not effective for certain patients with moderate to severe AR.…”