Preliminary data on endoscopic treatment of vesicoureteric reflux with polyacrylate polyalcohol copolymer (Vantris®): Surgical outcome following single injection

Chertin, Boris; Arafeh, Wael Abu; Zeldin, Alexander; Kocherov, Stanislav

doi:10.1016/j.jpurol.2010.11.010

Cited by 34 publications

(18 citation statements)

References 17 publications

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“…Según los primeros estudios publicados, este agente tiene resultados a corto plazo (resolución del reflujo vesicoureteral) similares a los otros materiales actualmente utilizados, aunque todavía falta publicar los resultados del seguimiento a largo plazo. [20][21] Con respecto a las complicaciones, como las infecciones febriles, un reciente metanálisis que comparó el tratamiento endoscópico con diferentes sustancias (DX/HA, politetrafluoroetileno, colágeno, polimetilsiloxano y condrocitos), la cirugía abierta y la quimioprofilaxis informó datos de incidencia global de 6% para los pacientes sometidos a tratamiento endoscópico, y de entre 2,7% y 14,1% para los otros. 22 Los efectos adversos más frecuentes del t r a t a m i e n t o e n d o s c ó p i c o c o m p r e n d e n hidronefrosis transitoria, infección urinaria, hematuria, dolor en el flanco del lado tratado, vómitos y litiasis verdadera o falsa (en caso de calcificación de la sustancia inyectada cubierta de mucosa vesical) (Figura 2).…”

Section: Reflejo Vesicoureteral Tratamiento Endoscópico / 351unclassified

Reflujo vesicoureteral. Tratamiento endoscópico

et al. 2013

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Arch Argent Pediatr 2013;111(4):349-352 / 349 RESUMEN El reflujo vesicoureteral (RVU) es el flujo de orina desde la vejiga hasta el tracto urinario superior. Está presente en el 25% al 70% de los niños con infección urinaria asociada a pielonefritis. Se realizó una revisión de la bibliografía sobre el tratamiento endoscópico del RVU analizando las técnicas, los materiales utilizados, las indicaciones y las complicaciones descritas. De los artículos encontrados, se seleccionaron los más recientes y las Guías Europeas y Norteamericanas. El tratamiento endoscópico del reflujo, que se ha impuesto progresivamente como técnica de elección para el tratamiento primario del RVU asociado a pielonefritis o a infecciones, permite retrasar el recurso a la cirugía. Palabras clave: reflujo vesicoureteral, tratamiento endoscópico, infecciones, agente expansor. SUMMARY Introduction.Vesico-ureteral reflux (VUR) is defined as the retrograde flow of urine from the bladder to the upper urinary tract and is distinguished in primary and secondary. It is present in 25-70% of children who have a urinary tract infection (UTI) associated with pyelonephritis, the association between UTI and VUR predisposes children to have renal scarring with consequent alteration of the functionality until chronic renal failure. Material and methods. We realized a review of the literature on the endoscopic treatment of vesico-ureteral reflux analyzing the different techniques, materials used for endoscopic injection, indications and complications described in the literature. Results. Over 100 articles we found on the endoscopic treatment of reflux with indications, complications and outcomes in the short, medium and long term. Of these we selected the most recent and current European and American Guidelines. Conclusions INTRODUCCIÓNL a s i n f e c c i o n e s u r i n a r i a s representan un problema común en los niños, con una incidencia del 5% en las niñas, y del 1% al 2% en los varones. El reflujo vesicoureteral (RVU) se define como el flujo de orina retrógrado desde la vejiga hasta el tracto urinario superior; se distingue en secundario, cuando la etiología es muy clara (como obstrucción cervicouretral, vejiga neurógena, etc.) y primario, cuando no se puede identificar una causa que lo explique y s e p r e s u m e q u e l a a n o m a l í a obedece a un defecto anatómico de la unión ureterovesical. Este reflujo está presente en el 25% al 70% de los niños que tienen una infección urinaria asociada a pielonefritis y está demostrado que la asociación entre RVU e infección urinaria los predispone a tener cicatrices renales, c o n l a c o n s e c u e n t e a l t e r a c i ó n de la función, que puede llegar progresivamente a cuadros de daño renal crónico. La presencia de RVU les permite a las bacterias que están en la vejiga alcanzar la vía urinaria superior y el riñón, con la posibilidad de producir pielonefritis y nefropatía de reflujo. Las cicatrices pueden aparecer después de un solo episodio de pielonefritis, especialmente en los niños pequeños. 1En l...

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Section: Reflejo Vesicoureteral Tratamiento Endoscópico / 351unclassified

Reflujo vesicoureteral. Tratamiento endoscópico

et al. 2013

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“…It occurs in 1%-2% of the pediatric population and in 30%-40% of children presenting with urinary tract infection (UTI). [12] The association of reflux, UTI and renal scaring is well recognized and reflux nephropathy is a major cause of childhood hypertension and chronic renal failure. [23] The goal of vesicoureteric reflux (VUR) treatment is to prevent pyelonephritis and to preserve renal function.…”

Section: Introductionmentioning

confidence: 99%

The influence of ureteral orifice configuration on the success rate of endoscopic treatment of vesicoureteral reflux

et al. 2013

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Background:To investigate the effect of polyacrylate polyalcohol copolymer (Vantris) injection for the correction of VUR in children according to ureteral orifice shape and VUR grade.Materials and Methods:Forty children (29 girls and 11 boys) with 61 renal refluxing units (RRU) and primary VUR underwent endoscopic correction of their reflux, using Vantris. Under general anesthesia, routine cystoscopy was performed and ureteral orifice configuration and dynamic hydro distention grade were determined. The injection technique was STING, HIT or a combination of them. Ultrasound scan was performed one and 3 months after injection and radionuclide cystography (RNC) was performed 3 months after the operation.Results:The mean volume of injected Vantris was 0.62 cc. Reflux was corrected in 52 (85.2%) of the 61 RRU after single injection and this equates reflux correction in 37 of the 40 patients. No significant correlation was observed between ureteral orifice shape and VUR correction rate.Conclusions:Our results showed that there was no correlation between the ureteral orifice configuration and the success rate of endoscopic surgery for VUR in short term.

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“…Chertin et al studied on 38 pediatric patients with 59 RU and reported a success rate of 95% in first 3 months of injection. In 21 patients the treatment was successful at the end of 1 year follow-up (19). In our study, 81% (29 RU) success rate was recorded by injection of PPC.…”

Section: Discussionmentioning

confidence: 45%

Endoscopic treatment of vesicoureteral reflux with polyacrylate polyalcohol copolymer and dextranomer/hyaluronic acid in adults

Türk¹,

Selimoglu

Demır

et al. 2014

Int. braz j urol.

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ARTICLE INFO ______________________________________________________________ ______________________Purpose: Aim of this study is to examine the effectiveness of dextranomer/hyaluronic acid copolymer and polyacrylate polyalcohol copolymer in endoscopic treatment of vesicoureteral reflux disease in adult patients with and without chronic renal failure. Materials and Methods: Thirty two patients (12 female, 20 male) with a total of 50 renal units were treated for vesicoureteral reflux. There were 26 (81%) chronic renal failure patients. The success of treatment was evaluated by voiding cystouretrography at 3rd and 12th months after subureteric injection. The persistence of reflux was considered as failure. Patients were divided into two groups according to injected material. Age, sex, grade of reflux and treatment results were recorded and evaluated.Results: Reflux was scored as grade 1 in seven (14%), grade 2 in 16 (32%), grade 3 in 21 (42%) and grade 4 in six (12%) renal units. There was not patient with grade 5 reflux. Fourteen renal units (28%) were treated with dextranomer/hyaluronic acid copolymer (group 1) and 36 renal units (72%) were treated with polyacrylate polyalcohol copolymer (group 2). The overall treatment success was achieved at 40 renal units (80%). The treatment was successful at 11 renal units (79%) in group 1 and 29 renal units (81%) in group 2 (p = 0.71). There was not statistically significant difference between two groups with patients with chronic renal failure in terms of treatment success (p = 1.00). Conclusions:The effectiveness of two bulking agents was similar in treatment of vesicoureteral reflux disease in adult patients and patients with chronic renal failure.

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Preliminary data on endoscopic treatment of vesicoureteric reflux with polyacrylate polyalcohol copolymer (Vantris®): Surgical outcome following single injection

Cited by 34 publications

References 17 publications

Reflujo vesicoureteral. Tratamiento endoscópico

Reflujo vesicoureteral. Tratamiento endoscópico

The influence of ureteral orifice configuration on the success rate of endoscopic treatment of vesicoureteral reflux

Endoscopic treatment of vesicoureteral reflux with polyacrylate polyalcohol copolymer and dextranomer/hyaluronic acid in adults

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