After the September 11 attack, the resistant capability of containments against aircraft impacts is required to be assessed for newly constructed nuclear power plants (NPPs). In this paper, the crash of a commercial airplane Boeing 767-200ER on the reinforced concrete containment building of an NPP is analyzed using the missile-target interaction method. Two plane models with the same total weight but different fuel distribution are analyzed. The force-time history obtained by FEA (finite element analysis) is compared with the one calculated by the Riera function. In the integral analysis, the mesh sensitivity of the reinforced concrete containment model is studied, and recommendations are provided on the modelling of containment. The impact phenomenon and damage on the containment are investigated through the validated model. The fuel distribution in the aircraft is found to have strong influence on the damage of the containment, which indicates that the load distribution in the transverse direction is critical in the analysis of aircraft impact. The classic load-time function analysis is unable to incorporate this factor and may not be adequate to provide satisfactory results. For this reason, the application of an integral analysis is advantageous in the safety assessment of aircraft impact.