Preliminary evaluation of intratumoral injection of a streptococcus pyrogenes preparation in patients with malignant brain tumors

Tanaka, Ryuichi; Sekiguchi, Kentaro; Suzuki, Yasuo; Sobue, H; Ueki, Keisuke

doi:10.1002/1097-0142(19801001)46:7<1688::aid-cncr2820460731>3.0.co;2-l

Cited by 10 publications

(4 citation statements)

References 5 publications

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“…Antitumor effects of intratumoral administration of OK-432 have been significantly shown in patients with breast and maxillar cancer. When administered intratumorally, OK-432 can induce local inflammatory granulomatous reactions, as has been shown in Calmette-Guerin (BCG) bacillus-injected tumors [7]. Furthermore, intracerebral injection of OK-432 in patients with malignant brain tumors induced inflammatory reactions without causing neurotoxic effects on the central nervous system.…”

Section: Discussionmentioning

confidence: 83%

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Management of cerebrospinal fluid leakage complicating anterior procedures through thoracotomy: report of three cases

2001

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Postoperative cerebrospinal fluid (CSF) leakage is a serious complication accompanying an anterior procedure through thoracotomy, and it is difficult to cure. In this report, we present three patients with CSF leakage in the thoracic spine complicating anterior decompression and fusion for ossification of posterior longitudinal ligament who were treated by surgical or nonsurgical methods. As a surgical method, direct closure by fixing substitute dura mater with fibrin adhesive sealant or cyanoacrylate adhesive was performed in two patients. This technique was effective but required another thoracotomy. As a nonsurgical method, intrapleural administration of OK-432 through chest drainage tubes was also effective to reduce intrapleural effusions in one patient, but with this method, care must be taken for neurotoxic reactions. Both techniques seem to be useful and effective for postoperative intrapleural CSF leakages complicating anterior procedures through thoracotomy.

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Section: Discussionmentioning

confidence: 83%

“…OK-432, which was used in case 3, has been shown to have antitumor activity in cancer patients [7,8]. Systemic administration of OK-432 increases the activity of blood natural killer (NK) cells, which play an important role in host resistance against tumors.…”

Section: Discussionmentioning

confidence: 99%

Management of cerebrospinal fluid leakage complicating anterior procedures through thoracotomy: report of three cases

2001

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“…The divergent results in the statistical tests (Log-rank vs. Gehan-Breslow-Wilcoxon) suggest that the potential effect of SSIs applies more to early recurrences and is limited in time. The hypothesized mechanisms of a potential survival benefit of SSI patients relate to local processes including a local immune reaction (competition between recruited immune cells and tumor cells for proteins and nutrients), activation of anti-tumor immune cells and release of specific cytokines or potential bacterial anti-cancer toxins (De Bonis et al 2011 ; Hayes et al 1995 ; Kazim et al 2021 ; Löhr et al 2013 ; Tanaka et al 1980 ). Furthermore, it has recently been demonstrated, that bacterial peptides might activate tumor-infiltrating T-cells in glioblastoma and lead to an anti-tumor effect (Naghavian et al 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Surgical site infections after glioblastoma surgery: boon or bane?

Hounchonou,

Bajgora,

Esmaeilzadeh

et al. 2024

J Cancer Res Clin Oncol

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Background Surgical site infections (SSIs) are among the most common postoperative complications. Glioblastoma multiforme is the most frequent malignant brain tumor with a dismal prognosis despite combined treatment. The effect of SSIs on the course of glioblastoma patients has not been fully clarified since available data are limited and partially contradictory. The aim of this study is to investigate the impact of SSIs on the course of patients with glioblastoma. Methods The medical records of all patients undergoing surgery for glioblastoma between 2010 and 2020 in our institution were scanned and those with surgical site infections after glioblastoma resection were identified and compared to an age-matched control group. Overall survival and progression-free survival were the primary endpoints followed by the number of hospitalizations and the length of stay in hospital. Results Out of 305 patients undergoing surgery for glioblastoma, 38 patients with postoperative surgical site infection after resection were identified and 15 (5 men and 10 women aged between 9 and 72) were included in this study. 23 patients were excluded. The control group consisted of 30 age-matched patients without SSI (18 men and 12 women). There were no significant differences in median overall survival. Progression-free survival was higher in the SSI group. The number of hospitalizations and the length of stay were significantly higher in the SSI group. Conclusion Our data suggest that SSIs might reduce early recurrences without affecting overall survival. Furthermore, they might decrease health-related quality of life by doubling the total length of hospital stay.

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“…For instance, a study reported that intracerebrally implanted heat-inactivated staphylococcal epitopes mixed with 9L gliosarcoma cells in Wistar rats, led to significantly prolonged survival than experimental controls (46). In a study by Tanaka and colleagues, Picibanil, also called OK-432 (an immunopotentiator and a low virulent mutant strain of Lancefield's Type III, Group A Streptococcus pyogenes) was injected intratumorally in 13 patients with malignant brain tumors, resulting in significant tumor regression in 50% of patients (47). Further indirect evidence comes from basic science studies of antitumor effects of bacterial toxins.…”

Section: Mechanism(s) Implicated In Survival Benefit Of Bacterial Infections In Gbmmentioning

confidence: 99%

The Survival Benefit of Postoperative Bacterial Infections in Patients With Glioblastoma Multiforme: Myth or Reality?

et al. 2021

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Glioblastoma multiforme (GBM), the most common malignant brain tumor, universally carries a poor prognosis. Despite aggressive multimodality treatment, the median survival is ~18–20 months, depending on molecular subgroups. A long history of observations suggests antitumor effects of bacterial infections against malignant tumors. The present review summarizes and critically analyzes the clinical data providing evidence for or against the survival benefit of post-operative bacterial infections in GBM patients. Furthermore, we explore the probable underlying mechanism(s) from basic science studies on the topic. There are plausible explanations from immunobiology for the mechanism of the “favorable effect” of bacterial infections in GBM patients. However, available clinical literature does not provide a definitive association between postoperative bacterial infection and prolonged survival in GBM patients. The presently available, single-/multi-center and national database retrospective case-control studies on the topic provide conflicting results. A prospective randomized study on the subject is clearly not possible. Immunobiology literature supports development of genetically modified bacteria as part of multimodal regimen against GBM.

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Preliminary evaluation of intratumoral injection of a streptococcus pyrogenes preparation in patients with malignant brain tumors

Cited by 10 publications

References 5 publications

Management of cerebrospinal fluid leakage complicating anterior procedures through thoracotomy: report of three cases

Management of cerebrospinal fluid leakage complicating anterior procedures through thoracotomy: report of three cases

Surgical site infections after glioblastoma surgery: boon or bane?

The Survival Benefit of Postoperative Bacterial Infections in Patients With Glioblastoma Multiforme: Myth or Reality?

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