Preliminary evaluation of reflectance confocal microscopy features of scalp melanoma

Benati, Elisa; Longo, Caterina; Piana, Simonetta; Moscarella, Elvira

doi:10.1111/ajd.12690

Cited by 7 publications

(15 citation statements)

References 20 publications

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“…Skin biopsy is usually required for the main diagnosis but cannot be routinely performed for therapeutic follow‐up 14 . RCM has shown to be a good tool for monitoring response in LPP, 14 cutaneous T‐cell lymphoma causing scalp alopecia, 19 and scalp melanoma 21 …”

Section: Discussionmentioning

confidence: 99%

Concordance among in vivo reflectance confocal microscopy, trichoscopy, and histopathology in the evaluation of scalp discoid lupus

Melo

Carvalho

Ardigò

et al. 2020

Skin Research and Technology

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Background: Reflectance confocal microscopy (RCM) has been used for the evaluation of several inflammatory skin conditions, including skin discoid lupus erythematosus (DLE), and has been correlated with conventional histopathology (HP). However, RCM is not being widely used in trichology. Few reports and just preliminary data suggest the use of RCM as a complementary tool in alopecias. Objectives: To correlate the major RCM features of scalp DLE with trichoscopy and HP findings of biopsy specimens obtained from the same lesions. Methods: This is an observational, analytical, and cross-sectional study involving 12 patients with a clinically established diagnosis of scalp DLE. Patients underwent global clinical photograph, trichoscopy, and RCM examination in the same site followed by two 4-mm punch biopsy specimens for HP analysis. Inter-methods agreement among RCM imaging, trichoscopy, and horizontal histopathology sections (HHS) were calculated using Cohen Kappa (k) statistics. Results: Statistical analysis of the agreement between RCM and HP features disclosed an overall agreement similar to skin DLE. Seven of the eleven features evaluated had agreement superior to 75%. We also evaluated RCM features associated with three of their corresponding trichoscopic findings for further investigation of their agreement with HP. Statistical analysis showed an enhancement with agreement of 86% when the non-invasive techniques are used together. Conclusion: Consistent correlation between RCM and HP observed in our study supports the reliability of RCM in the diagnosis of scalp DLE. RCM may be considered a promising tool for scalp DLE microscopic evaluation and presents similar RCM features to DLE in other body sites. By associating clinical, trichoscopic and RCM evaluation, dermatologists will have a non-invasive arsenal for the assessment of hair and scalp disorders, benefiting patients.

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Section: Discussionmentioning

confidence: 99%

Concordance among in vivo reflectance confocal microscopy, trichoscopy, and histopathology in the evaluation of scalp discoid lupus

Melo

Carvalho

Ardigò

et al. 2020

Skin Research and Technology

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“…Melanoma of the scalp is an uncommon condition, accounting for nearly 3-5% of all cutaneous melanomas, 1,2 falling under the umbrella of melanoma located on special sites. 3,4 Previous studies report poor associated prognosis, [5][6][7][8][9][10][11] which may be due to the abundance of vessels and lymphatics in this anatomical location. [12][13][14][15][16] However, delayed diagnosis may also play a role, as detailed clinical and dermoscopic examination is often hindered by the presence of hair.…”

Section: Introductionmentioning

confidence: 95%

“…[33][34][35][36][37][38][39] To date, RCM features of scalp melanocytic lesions have only been reported for a small number of cases. 4 The current study aims to reveal dermoscopic and RCM features of atypical melanocytic lesions of the scalp, according to distinct topographic areas and histopathology melanoma classification as LMM or SSM.…”

Section: Introductionmentioning

confidence: 99%

“…Melanoma of the scalp is an uncommon condition, accounting for nearly 3–5% of all cutaneous melanomas, 1,2 falling under the umbrella of melanoma located on special sites 3,4 . Previous studies report poor associated prognosis, 5–11 which may be due to the abundance of vessels and lymphatics in this anatomical location 12–16 .…”

Section: Introductionmentioning

confidence: 99%

“…Reflectance confocal microscopy (RCM) is a non‐invasive imaging technique 32 that enables in vivo horizontal scanning of skin lesions at nearly histological resolution and has been proven to assist in routine evaluation of melanocytic lesions 33–39 . To date, RCM features of scalp melanocytic lesions have only been reported for a small number of cases 4 …”

Section: Introductionmentioning

confidence: 99%

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Flat scalp melanoma dermoscopic and reflectance confocal microscopy features correspond to histopathologic type and lesion location

Garbarino

Pampena

Lai

et al. 2021

Acad Dermatol Venereol

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Background Dermoscopy and Reflectance Confocal Microscopy (RCM) features of scalp melanoma according to lesion location and histopathology have not been fully investigated.Objectives To reveal dermoscopic and RCM features of scalp melanoma according to lesion location and histopathology. MethodsWe retrospectively retrieved images of suspicious, atypical excised, flat melanocytic lesions of the scalp, assessed on dermoscopy and RCM at five centres, from June 2007 to April 2020. Lesions were classified according to histopathological diagnoses of nevi, lentigo maligna melanoma (LM/LMM) or superficial spreading melanoma (SSM). Clinical, dermoscopic and RCM images were evaluated; LM/LMM and SSM subtypes were compared through multivariate analysis.Results Two hundred forty-seven lesions were included. In situ melanomas were mostly LM (81.3%), while invasive melanomas were mostly SSM (75.8%). Male sex, baldness and chronic sun-damaged skin were associated with all types of melanomas and in particular with LM/LMM. LMs were mostly located in the vertex area and SSM in the frontal (OR: 8.8; P < 0.05, CI 95%) and temporal (OR: 16.7; P < 0.005, CI 95%) areas. The dermoscopy presence of pseudonetwork, pigmented rhomboidal structures, obliterated hair follicles and annular-granular pattern were associated with LM diagnoses, whereas bluish-white veil was more typical of SSM. Observations on RCM of atypical roundish and dendritic cells in the epidermis were associated with SSM (42.4%) and dendritic cells with LM (62.5%) diagnoses. Folliculotropism on RCM was confirmed as a typical sign of LM.Conclusions Flat scalp melanomas reveal specific dermoscopic and RCM features according to histopathologic type and scalp location.

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Ancillary Tools for Dermatological Skin Assessment: Dermoscopy, Reflectance Confocal Microscopy and Optical Coherence Tomography

Sortino

Abdalla

et al. 2023

Oncodermatology

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Preliminary evaluation of reflectance confocal microscopy features of scalp melanoma

Cited by 7 publications

References 20 publications

Concordance among in vivo reflectance confocal microscopy, trichoscopy, and histopathology in the evaluation of scalp discoid lupus

Concordance among in vivo reflectance confocal microscopy, trichoscopy, and histopathology in the evaluation of scalp discoid lupus

Flat scalp melanoma dermoscopic and reflectance confocal microscopy features correspond to histopathologic type and lesion location

Ancillary Tools for Dermatological Skin Assessment: Dermoscopy, Reflectance Confocal Microscopy and Optical Coherence Tomography

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