Preliminary experience on the implementation of computed tomography (CT)-based image guided brachytherapy (IGBT) of cervical cancer using high-dose-rate (HDR) Cobalt-60 source in University of Malaya Medical Centre (UMMC)

Jamalludin, Zulaikha; Min, Ung Ngie; Ishak, Wan Zamaniah Wan; Malik, Rozita Abdul

doi:10.1088/1742-6596/694/1/012016

Cited by 5 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An attempt was made to compare the EQD 2 of D 90 CTV HR and OARs. In the literature, we found different dose schedules like 5 Gy × 5 fractions, 6 Gy × 4 fractions, 7 Gy × 4 fractions, 7.5 Gy × 3 fractions, and 9 Gy × 2 fractions being applied in practice [9,10,11,12,13,14,15,16]. The choice of fractionation schedule of a particular oncology center mainly depends on the number of patients, availability of the staff, cost effectiveness, etc.…”

Section: Discussionmentioning

confidence: 99%

Impact of different dose prescription schedules on EQD2 in high-dose-rate intracavitary brachytherapy of carcinoma cervix

Kumar

Thangaraj

Alva

et al. 2019

jcb

View full text Add to dashboard Cite

Purpose To observe the effect of different high-dose-rate (HDR) intracavitary brachytherapy dose schedules on equieffective dose in 2 Gy per fraction (EQD 2 ). Material and methods It is a retrospective study involving 50 cervical cancer patients, who received external radiotherapy of 45 Gy in 25 fractions and underwent intracavitary brachytherapy (ICBT). Computed tomography (CT) simulation was done after insertion of the applicators. High-risk clinical target volume (CTVHR) and organs at risk (OARs) such as bladder, rectum, and sigmoid were contoured. Four different plans were generated for each patient, with dose prescriptions of 5.5 Gy × 5 fractions (plan A), 6.5 Gy × 4 fractions (plan B), 7 Gy × 4 fractions (plan C), and 9 Gy × 2 fractions (plan D), delivered to CTV HR . The total EQD 2 for 0.1 cm 3 and 2 cm 3 of bladder, rectum, and sigmoid as well as dose received by 90% of the CTV HR (D 90 ) and point A were calculated. The values were analyzed and compared with available literature. Results The mean CTV HR volume was 47.12 ±13.8 cm 3 . All plans delivered similar EQD 2 for 0.1 cm 3 and 2 cm 3 of sigmoid. Plan D delivered lesser EQD 2 compared to other plans for bladder, rectum, D 90 CTVHR, and point A ( p = 0.0001). Plan C delivered higher EQD 2 to OARs compared to other plans ( p = 0.001). Plan A, B, and plan C delivered similar EQD 2 for D 90 CTV HR and point A. Conclusions EQD 2 of bladder, rectum, sigmoid, D 90 CTV HR , and point A were similar with 5.5 Gy × 5 fractions, 6.5 Gy × 4 fractions, and 7 Gy × 4 fractions, whereas EQD 2 of 9 Gy × 2 fractions was significantly unfavorable compared to other schedules. Further clinical studies are recommended to observe clinical outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of different dose prescription schedules on EQD2 in high-dose-rate intracavitary brachytherapy of carcinoma cervix

Kumar

Thangaraj

Alva

et al. 2019

jcb

View full text Add to dashboard Cite

show abstract

“…The number of HDR-BT implant procedures, fractions per implant session and imaging are not standardized, either with multiple implants performed during external beam radiotherapy (EBRT) or afterwards [23] . The most commonly used HDR-BT fractionation scheme is 28 Gy in 4 fractions, using 2–4 implants and imaging is often done for each fraction or every two fractions [24] , [25] , [26] , [27] . However, due to anesthesiology human resources and operative room availability, hospitalization duration and imaging resources (MRI), BT organization remains a major issue and there is therefore a need to simplify this procedure as much as possible.…”

Section: Introductionmentioning

confidence: 99%

High-dose-rate brachytherapy boost for locally advanced cervical cancer: Oncological outcome and toxicity analysis of 4 fractionation schemes

Guyader

Kee

Thamphya

et al. 2022

Clinical and Translational Radiation Oncology

View full text Add to dashboard Cite

“…Current techniques include magnetic resonance imaging (MRI), positron emission tomography-computed tomography (PET-CT), and a histological biopsy. Both MRI (6,7) and PET-CT (8) are applied in the pretreatment detection of cervical cancer. However, due to the occurrence of fibrosis after treatment, the use of these imaging modalities during and after radiotherapy may lead to false-positive results.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic significance of magnetic resonance imaging in patients with cervical cancer after brachytherapy: a meta-analysis

Zhang

Tian

et al. 2018

Acta Radiol

View full text Add to dashboard Cite

Background Patients with uterine cervical cancer suffer high mortality. Accurate detection of a residual tumor by magnetic resonance imaging (MRI) during and after directed brachytherapy (BCT) is crucial for the success of cancer treatment and is a significant predictor of patient survival. Purpose To determine the diagnostic significance of MRI in detecting residual tumor tissue after BCT. Material and Methods The Web of Knowledge, Cochrane Library, and PubMed were systematically searched (January 1997 to December 2016) for post-brachytherapy MRI studies that measured residual tumors in patients with uterine cervical cancer. All data were analyzed using the Meta-Disc 1.4 program. Results Four clinical studies consisting of 163 patients (147 of whom were included in the present analysis) who were diagnosed with uterine cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging system were included in the study. All the patients received BCT and underwent MRI detection of residual tumors tissue. In studies where the accuracy of MRI detection was confirmed by histological tests or gynecological tests, the summary estimates of specificity, sensitivity, positive predictive value, negative predictive value, and accuracy were 88.5%, 83.5%, 53.5%, 97.1%, and 84.3%, respectively. Conclusion MRI-directed BCT is commonly used for cervical cancer patients. Based on our investigation of four independent studies, MRI showed better prediction of positive results than negative results in patients with cervical cancer after BCT. However, more data on the greater numbers of patients are needed to establish the accuracy of MRI detection of cervical cancer after BCT.

show abstract

Preliminary experience on the implementation of computed tomography (CT)-based image guided brachytherapy (IGBT) of cervical cancer using high-dose-rate (HDR) Cobalt-60 source in University of Malaya Medical Centre (UMMC)

Cited by 5 publications

References 4 publications

Impact of different dose prescription schedules on EQD2 in high-dose-rate intracavitary brachytherapy of carcinoma cervix

Impact of different dose prescription schedules on EQD2 in high-dose-rate intracavitary brachytherapy of carcinoma cervix

High-dose-rate brachytherapy boost for locally advanced cervical cancer: Oncological outcome and toxicity analysis of 4 fractionation schemes

Diagnostic significance of magnetic resonance imaging in patients with cervical cancer after brachytherapy: a meta-analysis

Contact Info

Product

Resources

About