Preliminary Experience With β-Tricalcium Phosphate for Use in Mastoid Cavity Obliteration After Mastoidectomy

Minoda, Ryosei; Hayashida, Momoko; Masuda, Mitsuharu; Yumoto, Eiji

doi:10.1097/mao.0b013e3181557b7c

Cited by 20 publications

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“…Unlike a-TCP, b-TCP is thermodynamically stable in a biological environment and within the normal temperature range. Despite their similar degree of solubility, b-TCP biodegrades more quickly than a-TCP [7]. Postoperative infections occur in 2-5% of mastoidectomies.…”

Section: Discussionmentioning

confidence: 96%

“…This leads to an epithelized lateral surface that isolates the mucosalized mesotympanic space, while ablating the mucosalized and pneumatized mastoid space. Various materials, both biological and alloplastic, have been used for mastoid obliteration [3][4][5][6][7][8]. Alloplastic material, including hydroxyapatite (HA) and beta-tricalcium phosphate (b-TCP) has been developed as a clinical bone substitute.…”

Section: Introductionmentioning

confidence: 99%

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Effect of piperacillin-tazobactam coated β-tricalcium phosphate for mastoid obliteration in otitis media

Jang

Cho

Yang

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Effect of piperacillin-tazobactam coated β-tricalcium phosphate for mastoid obliteration in otitis media

Jang

Cho

Yang

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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“…A donor site defect and difficulty in harvesting large volumes are additional problems. Various artificial materials are being used to compensate for the problems of autografts [17-20]. …”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of β-Tricalcium Phosphate and Polyphosphate for Mastoid Cavity Obliteration during Middle Ear Surgery: Human and Animal Study

Lee

Lim

Cho

et al. 2013

Clin Exp Otorhinolaryngol

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ObjectivesMastoid obliteration is used to obliterate the mastoid cavity following a mastoidectomy or to prevent the formation of a retraction pocket. This study evaluated the effectiveness of β-tricalcium phosphate and polyphosphate (β-TPP) for mastoid obliteration in middle ear surgeries in prospective human and animal studies.MethodsTwenty patients with chronic otitis media underwent mastoid obliteration using β-TPP after a intact canal wall mastoidectomy or simple mastoidectomy. The clinical data were prospectively evaluated including: the diagnosis, temporal bone computed tomography (TBCT), otoscopic findings, pure tone audiogram, and complications. In the animal experiment, β-TPP was applied into the right bulla in five rats, and the opposite bulla was used as the control in the non-obliterated state. The skulls of five other rats were drilled out and the holes were obliterated with β-TPP. TBCT were obtained at 3, 6, and 9 months after the obliteration and histologic analysis was done at 3 and 9 months after surgery.ResultsIn the human study, fourteen TBCTs were obtained at 12 months after the surgery. All demonstrated no bone resorption in the obliterated mastoids. Among the 15 cases displaying retracted tympanic membranes preoperatively, 11 showed no retraction, 2 showed retraction postoperatively, 1 was lost to follow-up and 1 was a case of postoperative wound infection. Among 20 cases, one case developed a postoperative infection that necessitated a second operation. Sixteen underwent ossiculoplasty; hearing improvements were obtained in 15 cases and 1 case showed decreased hearing. In the animal study, new bone formation without significant bone resorption in the radiologic and histologic findings were noted in both the skull and bulla groups.ConclusionAlthough β-TPP is a foreign material having the possibility of infection, mastoid obliteration with it can be a treatment option in middle ear surgeries to prevent retraction pockets or the recurrence of diseases.

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“…Nachteil der biologischen Materialien ist, dass Weichgewebe -und dazu gehört vor allen Dingen der Muskelanteil in einem gestielten Lappen wie beim Palva-Lappen [23] -zur Schrumpfung bzw. nachfolgenden Retraktion neigt [24]. So wird bei Verwendung eines Palva-Lappens in Kombination mit Knochenmehl eine Retraktionsbildung von 25 % (davon 48 % Fälle mit Retraktionscholesteatom) angegeben [25].…”

Section: Biologisches Materialsunclassified

Obliteration von Mastoidhöhlen

Schimanski¹,

Schimanski²

2015

HNO

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Preliminary Experience With β-Tricalcium Phosphate for Use in Mastoid Cavity Obliteration After Mastoidectomy

Abstract: Highly purified beta-TCP may be safe and reliable for mastoid obliteration. Highly purified beta-TCP may also be useful in other surgical procedures, including posterior wall reconstruction of the external auditory canal and scutum plasty.

Cited by 20 publications

References 0 publications

Effect of piperacillin-tazobactam coated β-tricalcium phosphate for mastoid obliteration in otitis media

Effect of piperacillin-tazobactam coated β-tricalcium phosphate for mastoid obliteration in otitis media

Clinical Significance of β-Tricalcium Phosphate and Polyphosphate for Mastoid Cavity Obliteration during Middle Ear Surgery: Human and Animal Study

Obliteration von Mastoidhöhlen

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