Preliminary Findings on the Effect of Ultrasmall Superparamagnetic Iron Oxide Nanoparticles and Acute Stress on Selected Markers of Oxidative Stress in Normotensive and Hypertensive Rats

Laubertová, Lucia; Dvořáková, Monika; Bališ, Peter; Púzserová, Angelika; Žitňanová, Ingrid; Bernátová, Iveta

doi:10.3390/antiox11040751

Cited by 3 publications

(1 citation statement)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NPs that have an inactive surface or low solubility can induce toxicity without causing oxidative stress [88]. In addition, in some works, it was shown that during the experimental therapy of animal models of pathology (stress, blood loss), magnetite NPs exerted an antioxidant effect [89,90].…”

Section: Targets and Mechanisms Of Toxic Action Of Magnetite Nanopart...mentioning

confidence: 99%

Toxicity Factors of Magnetite Nanoparticles and Methods of Their Research

Vazhnichaya,

Semaka,

Lutsenko

et al. 2024

Innov Biosyst Bioeng

View full text Add to dashboard Cite

Among nanoparticles (NPs) of metal oxides, magnetite NPs are the most well-known. The need for regulations related to the safety of magnetite NPs requires a deep understanding of their toxicological paradigm. The purpose of the presented review is to analyze the methods of studying the magnetite NPs toxicity and to summarize their toxicity factors based on the literature data. Literature sources were searched in the PubMed database, and 99 works were selected, supplemented with articles from other databases in some cases. It is shown that the study of the magnetite NPs toxicity became widespread during the last decade, reflecting the expansion of the list of synthesized magnetic NPs and the awareness that the prospects for their use depend on the safety of the created nanomaterial. The safety assessment of magnetite NPs on cell lines is the most popular. Primitive and more highly organized animals can be used to evaluate various aspects of the magnetite NPs toxicity. The toxicity factors of magnetite NPs depend on their characteristics (core composition, coating, size, and shape) and the mode of application (concentration, dose, exposure, type of cells, or animal model). One of the main mechanisms of nanomagnetite toxicity is the interference with iron metabolism and increased generation of reactive oxygen species leading to the disruption of cell proliferation, viability, and metabolism. Thus, the toxicity of magnetite NPs is studied by various methods and at different levels of living systems. Understanding the mechanisms of nanotoxicity should contribute to the targeted design of safe magnetic NPs.

show abstract

Section: Targets and Mechanisms Of Toxic Action Of Magnetite Nanopart...mentioning

confidence: 99%

Toxicity Factors of Magnetite Nanoparticles and Methods of Their Research

Vazhnichaya,

Semaka,

Lutsenko

et al. 2024

Innov Biosyst Bioeng

View full text Add to dashboard Cite

show abstract

Biomarkers of oxidative stress in acute blood loss and its correction with magnetite nanoparticles in a sodium chloride matrix

Lytvyn,

Vazhnichaya,

Kurapov

et al. 2023

Nano-Structures & Nano-Objects

View full text Add to dashboard Cite

Effects of Iron Nanoparticles Administration on Ischemia/Reperfusion Injury in Isolated Hearts of Male Wistar Rats

Kindernay¹,

Ferenczyová²,

Farkasova³

et al. 2023

Physiol Res

View full text Add to dashboard Cite

Iron is an essential mineral participating in numerous biological processes in the organism under physiological conditions. However, it may be also involved in the pathological mechanisms activated in various cardiovascular diseases including myocardial ischemia/reperfusion (I/R) injury, due to its involvement in reactive oxygen species (ROS) production. Furthermore, iron has been reported to participate in the mechanisms of iron-dependent cell death defined as “ferroptosis”. On the other hand, iron may be also involved in the adaptive processes of ischemic preconditioning (IPC). This study aimed to elucidate whether small amounts of iron may modify the cardiac response to I/R in isolated perfused rat hearts and their protection by IPC. Pretreatment of the hearts with iron nanoparticles 15 min prior to sustained ischemia (iron preconditioning, Fe-PC) did not attenuate post-I/R contractile dysfunction. Recovery of left ventricular developed pressure (LVDP) was significantly improved only in the group with combined pretreatment with iron and IPC. Similarly, the rates of contraction and relaxation [+/-(dP/dt)max] were almost completely restored in the group preconditioned with a combination of iron and IPC but not with iron alone. In addition, the severity of reperfusion arrhythmias was reduced only in the iron+IPC group. No changes in protein levels of “survival” kinases of the RISK pathway (Reperfusion Injury Salvage Kinase) were found except for reduced caspase 3 levels in both preconditioned groups. The results indicate that a failure to precondition rat hearts with iron may be associated with the absent upregulation of RISK proteins and the pro-ferroptotic effect manifested by reduced glutathione peroxidase 4 (GPX4) levels. However, combination with IPC suppressed the negative effects of iron resulting in cardioprotection.

show abstract

Preliminary Findings on the Effect of Ultrasmall Superparamagnetic Iron Oxide Nanoparticles and Acute Stress on Selected Markers of Oxidative Stress in Normotensive and Hypertensive Rats

Cited by 3 publications

References 63 publications

Toxicity Factors of Magnetite Nanoparticles and Methods of Their Research

Toxicity Factors of Magnetite Nanoparticles and Methods of Their Research

Biomarkers of oxidative stress in acute blood loss and its correction with magnetite nanoparticles in a sodium chloride matrix

Effects of Iron Nanoparticles Administration on Ischemia/Reperfusion Injury in Isolated Hearts of Male Wistar Rats

Contact Info

Product

Resources

About