Preliminary hemocompatibility assessment of an innovative material for blood contacting surfaces

Todesco, Martina; Pontara, Elena; Cheng, Chun‐Yan; Gerosa, Gino; Pengo, Vittorio; Bagno, Andrea

doi:10.1007/s10856-021-06556-0

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Moreover, the favorable interaction between a material and the blood tissue is strongly contingent on composition, internal morphology, porosity, surface roughness and chemistry etc. [ 44 , 45 , 46 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings

Baron

Duceac

Morariu³

et al. 2022

Gels

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The impetus for research into hydrogels based on selectively oxidized polysaccharides has been stimulated by the diversity of potential biomedical applications. Towards the development of a hemostatic wound dressing in this study, we creatively combined the (hemi)acetal and Schiff base bonds to prepare a series of multifunctional cryogels based on dialdehyde pullulan and dopamine. The designed structures were verified by NMR and FTIR spectroscopy. Network parameters and dynamic sorption studies were correlated with environmental scanning microscopy results, thus confirming the successful integration of the two components and the opportunities for finely tuning the structure–properties balance. The viscoelastic parameters (storage and loss moduli, complex and apparent viscosities, zero shear viscosity, yield stress) and the structural recovery capacity after applying a large deformation were determined and discussed. The mechanical stability and hemostatic activity suggest that the optimal combination of selectively oxidized pullulan and dopamine can be a promising toolkit for wound management.

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Section: Resultsmentioning

confidence: 99%

Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings

Baron

Duceac

Morariu³

et al. 2022

Gels

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show abstract

“…The hemocompatibility of these innovative materials was investigated by assessing their capacity to promote thrombin generation and induce platelet activation. Our preliminary results demonstrated that the proposed hybrid membranes are compatible with blood [131].…”

Section: Total Artificial Heart (Tah)mentioning

confidence: 65%

Biomaterials and Their Biomedical Applications: From Replacement to Regeneration

Todros¹,

Todesco²,

Bagno³

2021

Processes

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The history of biomaterials dates back to the mists of time: human beings had always used exogenous materials to facilitate wound healing and try to restore damaged tissues and organs. Nowadays, a wide variety of materials are commercially available and many others are under investigation to both maintain and restore bodily functions. Emerging clinical needs forced the development of new biomaterials, and lately discovered biomaterials allowed for the performing of new clinical applications. The definition of biomaterials as materials specifically conceived for biomedical uses was raised when it was acknowledged that they have to possess a fundamental feature: biocompatibility. At first, biocompatibility was mainly associated with biologically inert substances; around the 1970s, bioactivity was first discovered and the definition of biomaterials was consequently extended. At present, it also includes biologically derived materials and biological tissues. The present work aims at walking across the history of biomaterials, looking towards the scientific literature published on this matter. Finally, some current applications of biomaterials are briefly depicted and their future exploitation is hypothesized.

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“…Recently, Todesco et al [135] combined decellularized pericardium with polycarbonate urethanes (Chronoflex AR and Chronoflex ARLT) to avoid the use of glutaraldehyde [26]. These two polymers are widely used in the biomedical field, particularly in cardiovascular applications, and their biocompatibility has already undergone extensive in vitro assessment [136].…”

Section: Hybrid Materials In the Cardiovascular Field: A Challenge Fo...mentioning

confidence: 99%

Hybrid Materials for Tissue Repair and Replacement: Another Frontier in Biomaterial Exploitation Focusing on Cardiovascular and Urological Fields

et al. 2023

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The main purpose of tissue engineering is to fabricate and exploit engineered constructs suitable for the effective replacement of damaged tissues and organs to perfectly integrate with the host’s organism without eliciting any adverse reaction. Ideally, autologous materials represent the best option, but they are often limited due to the low availability of compatible healthy tissues. So far, one therapeutic approach relies on the exploitation of synthetic materials as they exhibit good features in terms of impermeability, deformability, and flexibility, but present chronic risks of infections and inflammations. Alternatively, biological materials, including naturally derived ones and acellular tissue matrices of human or animal origin, can be used to induce cells growth and differentiation, which are needed for tissue regeneration; however, this kind of material lacks satisfactory mechanical resistance and reproducibility, affecting their clinical application. In order to overcome the above-mentioned limitations, hybrid materials, which can be obtained by coupling synthetic polymers and biological materials, have been investigated with the aim to improve biological compatibility and mechanical features. Currently, the interest in these materials is growing, but the ideal ones have not been found yet. The present review aims at exploring some applications of hybrid materials, with particular mention to urological and cardiovascular fields. In the first case, the efforts to find a construct that can guarantee impermeability, mechanical resistance, and patency is herein illustrated; in the second case, the search for impermeability, hemocompatibility and adequate compliance is disclosed.

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Preliminary hemocompatibility assessment of an innovative material for blood contacting surfaces

Cited by 6 publications

References 23 publications

Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings

Hemostatic Cryogels Based on Oxidized Pullulan/Dopamine with Potential Use as Wound Dressings

Biomaterials and Their Biomedical Applications: From Replacement to Regeneration

Hybrid Materials for Tissue Repair and Replacement: Another Frontier in Biomaterial Exploitation Focusing on Cardiovascular and Urological Fields

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