Preliminary investigation of near-infrared spectroscopic measurements of urea, creatinine, glucose, protein, and ketone in urine

Pezzaniti, J.Larry; Jeng, Tzyy‐Wen; McDowell, Larry; Oosta, G M

doi:10.1016/s0009-9120(01)00198-9

Cited by 67 publications

(31 citation statements)

References 14 publications

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“…Regarding the accuracy of the glucose level prediction, the SEP between predicted and measured glucose concentration was 35.9 mg/dl (see the upper figure of Figure 3). This value is much lower than the value reported by Pezzaniti et al [7] (4.3 mmol/l = 77.4 mg/dl). This difference may cause from the difference in the used spectral range.…”

Section: Calibration and Validation Using Urine Samplecontrasting

confidence: 68%

Development of a near-infrared spectroscopic system for monitoring urine glucose level for the use of long-term home healthcare

et al. 2010

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We have been developing a new technique for measuring urine glucose concentration using near infrared spectroscopy (NIRS) in conjunction with the Partial Least Square (PLS) method. In the previous study, we reported some results of preliminary experiments for assessing feasibility of this method using a FT-IR spectrometer. In this study, considering practicability of the system, a flow-through cell with the optical path length of 10 mm was newly introduced. Accuracy of the system was verified by the preliminary experiments using urine samples. From the results obtained, it was clearly demonstrated that the present method had a capability of predicting individual urine glucose level with reasonable accuracy (the minimum value of standard error of prediction: SEP = 22.3 mg/dl) and appeared to be a useful means for long-term home health care. However, mean value of SEP obtained by the urine samples from ten subjects was not satisfactorily low (53.7 mg/dl). For improving the accuracy, (1) mechanical stability of the optical system should be improved, (2) the method for normalizing the spectrum should be reconsidered, and (3) the number of subject should be increased.

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Section: Calibration and Validation Using Urine Samplecontrasting

confidence: 68%

Development of a near-infrared spectroscopic system for monitoring urine glucose level for the use of long-term home healthcare

et al. 2010

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“…As a substitute for conventional blood sampling by pricking a finger, a variety of optical methods based on near-infrared (NIR) spectroscopy have been proposed and developed to measure blood glucose noninvasively. [2][3][4][5][6][7] However, those systems still have accuracy and reliability problems, so they are not widely used in clinical applications. One of the reasons for these problems is that the NIR spectroscopy method analyzes detected harmonic overtones of the target molecular vibrations.…”

Section: Introductionmentioning

confidence: 99%

Blood glucose measurement by using hollow optical fiber-based attenuated total reflection probe

2014

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Abstract. A noninvasive glucose monitoring system based on mid-infrared, attenuated total reflection spectroscopy using a hollow optical fiber probe is developed. Owing to the flexible fiber probe, measurement of oral mucosa, where blood capillaries are near the skin surface, is possible. Blood glucose levels are measured by detecting the peak intensity of glucose absorption bands, and the experimental results showed that the reproducibility of the measurement is high enough for monitoring blood glucose. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…Several groups have used near-IR spectroscopy, i.e., the range of vibrational overtones, for the detection of blood and urine constituents, predominantly glucose [4,5]. This method was also used to determine urea concentration in dialysate samples [6][7][8] or by using a bypass flow through a flow-through cell [9].…”

Section: Introductionmentioning

confidence: 99%

Infrared spectroscopy in hemodialysis: reagent-free monitoring of patient detoxification by infrared spectroscopy

et al. 2012

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A method for monitoring hemodialysis based on quantitative infrared spectroscopic determination of the molecules dialyzed from patient blood is reported. The measurements are reagent-free and aim at real-time and in-line monitoring of the hemodialysis patient. A flow cell using attenuated total reflection infrared spectroscopy is coupled downstream of the dialysis filter unit. A calibration model has been developed from real hemodialysis samples analyzed by chemical reference analysis and from artificially mixed dialysis samples. The infrared monitoring of hemodialysis includes quantitative determination of urea as the lead substance, as well as glucose, lactate, and creatinine, all at a precision only limited by the chemical reference analysis. The flow cell can be fitted to all standard hemodialysis systems. Preliminary tests with hemodialysis patients have demonstrated that detoxification can be clearly monitored. Furthermore, these experiments demonstrate that a wide, real-time control of the patient's physiological parameters is possible with this method, which could lead to increased patient safety.

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Preliminary investigation of near-infrared spectroscopic measurements of urea, creatinine, glucose, protein, and ketone in urine

Cited by 67 publications

References 14 publications

Development of a near-infrared spectroscopic system for monitoring urine glucose level for the use of long-term home healthcare

Development of a near-infrared spectroscopic system for monitoring urine glucose level for the use of long-term home healthcare

Blood glucose measurement by using hollow optical fiber-based attenuated total reflection probe

Infrared spectroscopy in hemodialysis: reagent-free monitoring of patient detoxification by infrared spectroscopy

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