Preliminary investigation of the NMR, optical and x-ray CT dose-response of polymer gel dosimeters with cosolvents and increased crosslinker levels

Evaluation of accuracy and precision in polymer gel dosimetry

“…PGD has natural advantages as a dosimetric tool as polymer gels are inherently 3D, tissue equivalent, and deformable. There has also been a significant amount of research into using less toxic, N‐isopropyl‐acrylamide (NIPAM)‐based gel formulations to further increase clinical appeal . Potential clinical applications of PGD include deformable dosimetry for verification of deformable dose calculations, end‐to‐end validation of the clinical treatment chain, and the evaluation of other dosimetry systems used for clinical quality assurance.…”

“…There has also been a significant amount of research into using less toxic, N-isopropyl-acrylamide (NIPAM)-based gel formulations to further increase clinical appeal. 13,[19][20][21][22] Potential clinical applications of PGD include deformable dosimetry for verification of deformable dose calculations, 23,24 end-to-end validation of the clinical treatment chain, and the evaluation of other dosimetry systems used for clinical quality assurance. With the advancement of radiation therapy toward complicated clinical techniques in fourdimensional (4D) and image-guided adaptive radiation therapy, the need for a truly 3D dosimeter is essential and the promise of polymer gels in this regard is yet to be fully realized clinically.…”