Preliminary Investigations of Microwave Imaging Algorithms for Tissue Temperature Estimation During Hyperthermia Treatment

Prokhorova, Alexandra; Ley, Sebastian; Ruiz, Álvaro Yago; Scapaticci, Rosa; Crocco, Lorenzo; Helbig, Marko

doi:10.1109/iceaa52647.2021.9539731

Cited by 6 publications

(6 citation statements)

References 13 publications

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“…Significant changes in signal level were found and correlated to the variation of the tumor average temperature, thus positively answering to the feasibility of the MW monitoring. The non-linear, ill-posed MW problem of finding the temperature variations of the EM contrast can be solved using qualitative [53], quantitative [62] or machine learning-based [89] methods. With these tools, the planning of experiments and validation tests could be devised and performed, thus paving the route for innovative and effective modalities in the ITH of tumors using MagS.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

“…Among the many biomedical applications of microwave (MW) diagnostic imaging [47]- [49], its use in the framework of thermal therapy looks promising, due to its capability of being a non-invasive, cost effective, fast and reliable strategy [50]- [52]. In particular, MW imaging is an approach under investigation for tissues temperature monitoring during hyperthermia [53] and ablation [54]. The working idea is to perform qualitative [50], [55]- [57] or quantitative MW imaging [47], [58]- [63] considering the beginning of the treatment as the reference configuration and then assessing, in a differential way, the spatial and temporal changes of the dielectric contrast due to the tissues temperature variation during the hyperthermia [53].…”

Section: Introductionmentioning

confidence: 99%

“…In particular, MW imaging is an approach under investigation for tissues temperature monitoring during hyperthermia [53] and ablation [54]. The working idea is to perform qualitative [50], [55]- [57] or quantitative MW imaging [47], [58]- [63] considering the beginning of the treatment as the reference configuration and then assessing, in a differential way, the spatial and temporal changes of the dielectric contrast due to the tissues temperature variation during the hyperthermia [53]. This principle could be applied to the IHT of bone tumors with MagS.…”

Section: Introductionmentioning

confidence: 99%

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Feasibility Analysis of Theranostic Magnetic Scaffolds for Microwave Monitoring of Hyperthermia Treatment of Bone Tumors

Lodi¹,

Curreli²,

Dachena³

et al. 2023

Preprint

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<p>Magnetic biomaterials are multifunctional tools currently under investigation as theranostic platforms for biomedical applications. They can be implanted in bone tissue after bone cancer resection to perform local interstitial hyperthermia treatment. Given the requirements of high quality treatment, the hyperthermia therapy should be performed monitoring the system temperature, to avoid hot spots and control the treatment outcome. It is known that the magnetic properties of such implants vary with temperature. It is hypotesized that the treatment dynamic could be monitored using a microwave monitoring system. The variation of the electromagnetic properties of the biological tissues and the magnetic implant during the therapy would result in a different propagation of the microwave signal. This work investigates the feasibility of using microwaves to non-invasively monitor hyperthermia treatments with a simplified monodimensional propagation model. The forward problem is solved to identify the working frequencies, the matching medium properties and study several candidate materials. By using the numerical solutions from nonlinear and multiphysics simulations of the bone tumor hyperthermia treatment using magnetic scaffolds, the microwave signal propagation dynamic is studied. From our feasibility analysis, we found that it is possible to correlate the average tumor temperature with significant (~20 dB) variations in the transmission coefficient during a typical interstitial hyperthermia session using magnetic scaffolds. Our work brings together, for the first time, the electromagnetic material properties, the physio-pathology and physics of the hyperthermia treatment and the microwave propagation problem, thus paving the route for the development of an innovative theranostic system.</p>

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Section: Conclusion and Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Feasibility Analysis of Theranostic Magnetic Scaffolds for Microwave Monitoring of Hyperthermia Treatment of Bone Tumors

Lodi¹,

Curreli²,

Dachena³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Among the many biomedical applications of microwave (MW) diagnostic imaging [47], [48], [49], its use in the framework of thermal therapy looks promising, due to its capability of being a non-invasive, cost effective, fast and reliable strategy [50], [51], [52]. In particular, MW imaging is an approach under investigation for tissues temperature monitoring during hyperthermia [53] and ablation [54]. The working idea is to perform qualitative [50], [55], [56], [57] or quantitative MW imaging [47], [58], [59], [60], [61], [62], [63] considering the beginning of the treatment as the reference configuration and then assessing, in a differential way, the spatial and temporal changes of the dielectric contrast due to the tissues temperature variation during the hyperthermia [53].…”

Section: Introductionmentioning

confidence: 99%

“…In particular, MW imaging is an approach under investigation for tissues temperature monitoring during hyperthermia [53] and ablation [54]. The working idea is to perform qualitative [50], [55], [56], [57] or quantitative MW imaging [47], [58], [59], [60], [61], [62], [63] considering the beginning of the treatment as the reference configuration and then assessing, in a differential way, the spatial and temporal changes of the dielectric contrast due to the tissues temperature variation during the hyperthermia [53]. This principle could be applied to the IHT of bone tumors with MagS.…”

Section: Introductionmentioning

confidence: 99%

Feasibility Analysis of Theranostic Magnetic Scaffolds for Microwave Monitoring of Hyperthermia Treatment of Bone Tumors

Lodi

Curreli

Dachena

et al. 2023

IEEE J. Electromagn. RF Microw. Med. Biol.

Self Cite

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Magnetic biomaterials are multifunctional tools currently under investigation as theranostic platforms for biomedical applications. They can be implanted in bone tissue after bone cancer resection to perform local interstitial hyperthermia treatment. Given the requirements of high quality treatment, the hyperthermia therapy should be performed monitoring the system temperature, to avoid hot spots and control the treatment outcome. It is known that the magnetic properties of such implants vary with temperature. It is hypotesized that the treatment dynamic could be monitored using a microwave monitoring system. The variation of the electromagnetic properties of the biological tissues and the magnetic implant during the therapy would result in a different propagation of the microwave signal. This work investigates the feasibility of using microwaves to non-invasively monitor hyperthermia treatments with a simplified monodimensional propagation model. The forward problem is solved to identify the working frequencies, the matching medium properties and study several candidate materials. By using the numerical solutions from nonlinear and multiphysics simulations of the bone tumor hyperthermia treatment using magnetic scaffolds, the microwave signal propagation dynamic is studied. From our feasibility analysis, we found that it is possible to correlate the average tumor temperature with significant (∼20 dB) variations in the transmission coefficient during a typical interstitial hyperthermia session using magnetic scaffolds. Our work brings together, for the first time, the electromagnetic material properties, the physio-pathology and physics Manuscript

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Microwave Ultra-Wideband Imaging for Non-invasive Temperature Monitoring During Hyperthermia Treatment

Prokhorova

Fišer

Vrba

et al. 2023

Lecture Notes in Bioengineering

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Preliminary Investigations of Microwave Imaging Algorithms for Tissue Temperature Estimation During Hyperthermia Treatment

Cited by 6 publications

References 13 publications

Feasibility Analysis of Theranostic Magnetic Scaffolds for Microwave Monitoring of Hyperthermia Treatment of Bone Tumors

Feasibility Analysis of Theranostic Magnetic Scaffolds for Microwave Monitoring of Hyperthermia Treatment of Bone Tumors

Feasibility Analysis of Theranostic Magnetic Scaffolds for Microwave Monitoring of Hyperthermia Treatment of Bone Tumors

Microwave Ultra-Wideband Imaging for Non-invasive Temperature Monitoring During Hyperthermia Treatment

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