PRELIMINARY PHYTOCHEMICAL AND PHARMACOLOGICAL INVESTIGATIONS OF THE ROOTS OF DIFFERENT VARIETIES OF<i>CICHORIUM INTYBUS</i>

Balbaa, S. I.; Zaki, AA; Abdelwahab, Sherif; El-Denshary, Ezz-El-Din S.; Motazz-Bellah, M

doi:10.1055/s-0028-1099480

Cited by 16 publications

(2 citation statements)

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“…Pharmacological study of eight varieties of Cichorium intybus on isolated toad's heart showed that the eight varieties have a quinidine like action, but with variable potency (46)(47) .…”

Section: Cichorium Intybusmentioning

confidence: 99%

Medicinal plants with beneficial effects on heart

Al-Snafi¹

2022

GSC Biol. and Pharm. Sci.

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Cardiovascular diseases (CVDs) kill 17.9 million people per year, by 2030, it is predicted that more than 22.2 million people will die annually from CVDs. Many medicinal plants possessed cardiac and anti-arrhythmic effects. The current study was designed to highlight the medicinal plants which possess beneficial effect in heart failure, protect heart from the toxicity of wide range of chemicals, and exert anti-arrhythmic activities.

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“…Pharmacological study of eight varieties of Cichorium intybus on isolated toad's heart showed that the eight varieties have a quinidine like action, but with variable potency (46)(47) .…”

Section: Cichorium Intybusmentioning

confidence: 99%

Medicinal plants with beneficial effects on heart

Al-Snafi¹

2022

GSC Biol. and Pharm. Sci.

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“…Extracts of chicory inhibit the growth of tumour cells through their content of the flavonoid quercetin (Hertog et al 1992) and the sesquiterpene lactone 11β, 13-dihydrolactucopicrin (Christope et al 1996). Balbaa et al (1973) examined the pharmacological properties of chicory extracts on hearts isolated from toads. Extracts had a quinidine-like action, verifying the use of such extracts against diseases characterized by tachycardia, arrhythmias and fibrillations, as indicated in folklore.…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of very long chain polyunsaturated fatty acids in the leafy vegetable chicory

Mekky¹,

MOHAMED²,

LAZARUS³

2011

AFSci

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The synthesis of very long chain polyunsaturated fatty acids (VLCPUFAs) was investigated in five cultivars of chicory. Genes for enzymes of the ω3/6 Δ 8-desaturation biosynthetic pathways for the formation of C20 VLCPUFAs were inserted into chicory by Agrobacterium-mediated transformation of leaf explants. Plants were transformed by genes encoding Δ 9-specific elongating activity from Isochrysis galbana, Δ 8-desaturase from Euglena gracilis and ∆ 5-desaturase from Mortierella alpina, either separately or in combination; transgenic plants were selected on culture medium containing glufosinate ammonium for those transformed with the ∆ 9-elongase gene alone or in combination with the ∆ 8-desaturase gene, or kanamycin for plants transformed with the ∆ 5-desaturase gene. PCR showed the presence of the transgenes within the genome of selected plants, with RT-PCR confirming gene expression. Gas Chromatography of fatty acid methyl esters extracted from freeze-dried leaves of transgenic plants quantified the synthesis of omega-6 arachidonic acid and its precursors eicosadienoic and dihomo-γ-linolenic acids, and omega-3 eicosapentaenoic acid together with its precursors eicosatrienoic and eicosatetraenoic acids. This is the first report of the production of VLCPUFAs in a leafy vegetable. Since VLCPUFAs are the precursors of prostaglandins, the formation of prostaglandins was also investigated in chicory following a second transformation event using the PGHS-1 gene from Mus musculus.

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Pregnancy and herbal medicines: An unnecessary risk for women's health—A narrative review

Bruno

Simões

et al. 2018

Phytotherapy Research

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The indiscriminate use of herbal medicines to prevent or to heal diseases or even the use for questionable purposes such as weight loss has received both interest and scrutiny from the scientific community and general public alike. An increasing number of women put their own and the unborn child's health at risk due to a lack of knowledge about the phytochemical properties and adequate use of herbal medicine (phytomedicines or herbal supplements) and lack of communication with their healthcare provider. The purpose of this narrative review was to summarize the use of herbal medicines during pregnancy and their potential toxic effects to highlight the importance of caution when prescribing herbal medicines or supplements for women, because, in addition to suffering interactions and a great amount of information obtained in preclinical predictive studies, assessment of nephrotoxicity, neurotoxicity, hepatotoxicity, genotoxicity, and teratogenicity of traditional medicinal herbs still remains scarce in the clinical setting.

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PRELIMINARY PHYTOCHEMICAL AND PHARMACOLOGICAL INVESTIGATIONS OF THE ROOTS OF DIFFERENT VARIETIES OFCICHORIUM INTYBUS

Cited by 16 publications

References 0 publications

Medicinal plants with beneficial effects on heart

Medicinal plants with beneficial effects on heart

Biosynthesis of very long chain polyunsaturated fatty acids in the leafy vegetable chicory

Pregnancy and herbal medicines: An unnecessary risk for women's health—A narrative review

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