Preliminary phytochemical, toxicity and anti-inflammatory evaluation of Commelina benghalensis

Abstract

Background: Commelina benghalensis is a widely used ethno medicinal plant for various diseases in India, but only few studies have been conducted in this plant. Objective: The present work was performed to screen phytochemical, toxicity and anti-inflammatory activity of hydroethanolic extract of leaves of C. benghalensis (Family: Commelinaceae). Materials and Methods: Hydroethanolic extract of leaves of C. benghalensis (HECB) was prepared and subjected to preliminary phytochemical investigations. Acute and sub-acute toxicity tests were performed in female Wistar rats. The anti-inflammatory activity was studied using carrageenan-induced rat paw edema, cotton pellet granuloma and xylene-induced ear edema models at two different doses (200 mg/kg and 400 mg/kg of body weight). Results: HECB did not show any toxic reactions in female rats, and a dose of 400 mg/kg exhibited significant anti-inflammatory activity in all three models as compared to the control group. Indomethacin 10 mg/kg also showed significant anti-inflammatory activity in all three models. Conclusion: These experimental results have established a pharmacological evidence for the folkloric use of the C. benghalensis as an anti-inflammatory agent. Determination of the median lethal dose (LD 50 ) revealed that the Commelina extracts was safe.

The Invasive Species Commelina benghalensis L.: A Step Towards The Biological Flora of Egypt

“…Phytochemical examinations of aerial parts extracts revealed the presence of saponin, tannins, flavonoid, glycosides and phytosterols. These results have been established by Augustine et al (2013) and Tadesse et al (2016). The phytoconstituent rich ethanolic extract was elucidated using GC-MS as one of the best techniques which allows simultaneous assessment of a variety of components in the plant (Hussain and Maqbool, 2014).…”

“…Previous studies on chemical investigation of C.benghalensis by GC-MS revealed the presence of fourteen different compounds; the most investigated compounds were belonging to acid group. Others suggested that this plant was a potential source of 10 pharmacologically active chemical compounds and therefore investigate its antifungal, antimicrobial and antiinflammatory activity (Cuéllar Cuéllar and Okori, 2010;Augustine et al, 2013;Kadam, 2016).…”

The genus Commelina: Focus on distribution, morphology, traditional medicinal uses, phytochemistry, and Ethno-pharmacological activities: An updated literature review

“…Commelina benghalensis extract significantly decreased xylene-induced ear edema at doses of 200 mg/kg and 400 mg/kg. This indicates the anti-phlogistic and substance P inhibition properties of Commelina extracts [ 47 ].…”

Pharmacological and histopathological assessment of <i>Phyllobotyron spathulatum</i> Müll.Arg.) in rats

“…A similar result to this study was reported by , who observed that the extract of Justicia secunda was well tolerated in mice as no signs of toxicity or death were noticed at 2 g/kg during the period under review. Tiwari et al (2013) attributed the toxicity, or otherwise, of an extract to the concentration or dose used in a system. Adeneye et al (2006) noted that the aqueous extract of Musanga cecropioides at a higher dose of 3000 mg/kg, was relatively safe toxicologically when administered orally.…”