Preliminary report of an autochthonous chikungunya outbreak in France, July to September 2017

Calba, Clémentine; Guerbois-Galla, Mathilde; Franke, Florian; Jeannin, Charles; Auzet-Caillaud, Michelle; Grard, Gilda; Pigaglio, L.; Decoppet, Anne; Weicherding, Joel; Savaill, Marie-Christine; Munoz-Riviero, Manuel; Chaud, P.; Cadiou, Bernard; Ramalli, L.; Fournier, Pierre; Noël, Harold; Lamballerie, Xavier De; Paty, Marie-Claire; Leparc-Goffart, Isabelle

doi:10.2807/1560-7917.es.2017.22.39.17-00647

Cited by 116 publications

(98 citation statements)

References 10 publications

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“…Exotic MBDs transmitted by Ae. albopictus are also of concern, with the recent incursion of this species into temperate regions elsewhere that are climatically similar to parts of Canada (61,64,65,90) and the emergence of one small region in Canada where Ae. albopictus appears to have become established (20).…”

Section: Discussionmentioning

confidence: 99%

Could exotic mosquito-borne diseases emerge in Canada with climate change?

Ng¹,

Rees²,

Lindsay³

et al. 2019

CCDR

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Section: Discussionmentioning

confidence: 99%

Could exotic mosquito-borne diseases emerge in Canada with climate change?

Ng¹,

Rees²,

Lindsay³

et al. 2019

CCDR

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“…In this regard, most of the cases in Europe are imported, although in the last two decades there have been different epidemic outbreaks in Italy 12 and, recently, in France. 13 In Spain, only imported cases have been reported. 14 This mosquito (next to Aedes aegypti which, as will be detailed later, has been detected in a timely manner in Europe) can act as a vector of the dengue virus and with less effectiveness of the Zika virus.…”

Section: Diptera (Mosquitoes and Phlebotominae Sand Flies) Overview Imentioning

confidence: 99%

Arthropods as vectors of transmissible diseases in Spain

Portillo

Ruíz-Arrondo

Oteo

2018

Medicina Clínica (English Edition)

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a b s t r a c tDifferent aspects related to globalization together with the great capacity of the arthropod vectors to adapt to a changing world favour the emergence and reemergence of numerous infectious diseases transmitted by them. Diptera (mosquitoes and sandflies), ticks, fleas and lice, among others, cause a wide spectrum of diseases with relevance in public health. Herein, arthropod-borne disease are reviewed, with special emphasis on the existing risk to contract them in Spain according to different parameters, such as the presence of arthropod and the circulation or the possible circulation of the causative agents. Artrópodos vectores en España y sus enfermedades transmisiblesPalabras clave: Artrópodo vector Garrapatas Mosquitos Pulgas España Arbovirus r e s u m e n Diferentes aspectos relacionados con la globalización junto a la gran capacidad de los artrópodos vectores para adaptarse a un mundo cambiante propician la emergencia y reemergencia de numerosos procesos infecciosos transmitidos por los mismos. Dípteros (culícidos y flebótomos), garrapatas, pulgas y piojos, entre otros, provocan un variado espectro de enfermedades con gran importancia en Salud Pública. En esta revisión se repasan las diferentes afecciones transmitidas por artrópodos vectores, haciendo un especial hincapié en el riesgo existente para contraerlas en España en función de diferentes parámetros, como la presencia del artrópodo y la circulación o posible circulación de los agentes causales.© 2018 Elsevier España, S.L.U. Todos los derechos reservados.Arthropods are the most abundant invertebrates of the animal kingdom. Their classification is very complex and among them are very diverse orders (

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“…A small CHIKV outbreak in the Caribbean at the end of 2013 marked its arrival in the Americas, from which over 1.5 million infections have been reported since 2014. Following its introduction in Italy (2007 and 2017) and France (2010 and 2017) on several occasions via infected travelers, CHIKV has caused limited locally transmitted outbreaks in Europe (6)(7)(8)(9). The geographical expansion of the Aedes albopictus vector and increased human travel pose the risk that CHIKV may become endemic in new territories.…”

mentioning

confidence: 99%

6′-β-Fluoro-Homoaristeromycin and 6′-Fluoro-Homoneplanocin A Are Potent Inhibitors of Chikungunya Virus Replication through Their Direct Effect on Viral Nonstructural Protein 1

Kovacikova

Morren

Taş

et al. 2020

Antimicrob Agents Chemother

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Alphaviruses are arthropod-borne, positive-stranded RNA viruses capable of causing severe disease with high morbidity. Chikungunya virus (CHIKV) is an alphavirus that causes a febrile illness which can progress into chronic arthralgia. The current lack of vaccines and specific treatment for CHIKV infection underscores the need to develop new therapeutic interventions. To discover new antiviral agents, we performed a compound screen in cell culture-based infection models and identified two carbocyclic adenosine analogues, 6=-␤-fluoro-homoaristeromycin (FHA) and 6=-fluoro-homoneplanocin A (FHNA), that displayed potent activity against CHIKV and Semliki Forest virus (SFV) with 50% effective concentrations in the nanomolar range at nontoxic concentrations. The compounds, designed as inhibitors of the host enzyme S-adenosylhomocysteine (SAH) hydrolase, impeded postentry steps in CHIKV and SFV replication. Selection of FHNA-resistant mutants and reverse genetics studies demonstrated that the combination of mutations G230R and K299E in CHIKV nonstructural protein 1 (nsP1) conferred resistance to the compounds. Enzymatic assays with purified wild-type (wt) SFV nsP1 suggested that an oxidized (3=-keto) form, rather than FHNA itself, directly inhibited the MTase activity, while a mutant protein with the K231R and K299E substitutions was insensitive to the compound. Both wt nsP1 and the resistant mutant were equally sensitive to the inhibitory effect of SAH. Our combined data suggest that FHA and FHNA inhibit CHIKV and SFV replication by directly targeting the MTase activity of nsP1, rather than through an indirect effect on host SAH hydrolase. The high potency and selectivity of these novel alphavirus mRNA capping inhibitors warrant further preclinical investigation of these compounds.

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Preliminary report of an autochthonous chikungunya outbreak in France, July to September 2017

Cited by 116 publications

References 10 publications

Could exotic mosquito-borne diseases emerge in Canada with climate change?

Could exotic mosquito-borne diseases emerge in Canada with climate change?

Arthropods as vectors of transmissible diseases in Spain

6′-β-Fluoro-Homoaristeromycin and 6′-Fluoro-Homoneplanocin A Are Potent Inhibitors of Chikungunya Virus Replication through Their Direct Effect on Viral Nonstructural Protein 1

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