Preliminary results of autologous adipose-derived stem cells in early knee osteoarthritis: identification of a subpopulation with greater response

Management of osteoarthritis - biological approaches: current concepts

“…The mean follow-up was 15.3 months, with the authors noting a significant improvement in IKS knee scores from a mean of 37.4 preoperatively to 62.6 postoperatively at the time of final follow-up. The mean IKS function score also improved from 57.2 to 83.0, and the mean VAS pain score decreased from 8.5 to 5.1 58. Without a control group of surgery alone, it is challenging to determine if the clinical improvement is attributable to the AD-MSC injection to some extent or simply the arthroscopic procedure.…”

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“…As already underlined in our previous review, Lipogems ® is currently used within the clinic in several orthopedic contraindications, where intra-articular injections are used to for the management of knee, hip and shoulder osteoarthritic degeneration (more than 35000 patients over the world). Initiated more than three years ago, these results have now been confirmed in several case series [50,51], and prospective clinical studies with follow up [52,53], and the "regenerative" pathophysiological mechanism of Lipogems ® , when injected into the joint, have now been more carefully elucidated [54,55]. MFAT has also been demonstrated effective also in four patients with osteochondral lesions of the talus [56] who underwent to arthroscopic injection of MFAT of the osteochondral lesion after a first phase of microperforation of the cartilage.…”

“…Jannelli E et al, [57], in an interesting position paper, proposed micro-fragmented fat tissue transplantation to treat delamination and first and second-degree chondral lesions also in knee arthroscopic surgery in order to regenerate cartilage and prevent severe grade of osteoarthritis. Schiavone Panni et al, [50] underlined in a recent case series in fifty-two patients also that MFAT treatment as an adjunct to arthroscopic debridement could be very effective also in patient with early knee osteoarthritis. They found a significative improvement after one year both of the pain scores and of the functional activity.…”

Comparative technical analysis of lipoaspirate mechanical processing devices

“…In one work (Brzezienski & Jarrell, 2016), surgeons indifferently used the GID700 and Puregraft devices, and no comparison of clinical results is made. The identified clinical results refer to multiple fields of application: 14 papers refer to breast reconstruction (Brzezienski & Jarrell, 2016;Chiu, Fracol, Feld, Qiu, & Kim, 2019;De Fazio & Cingozoglu, 2020;Economides & Song, 2018;Gabriel et al, 2017;Lee et al, 2011;Losken et al, 2011;Mestak et al, 2014;Mestak, Mestak, Bohac, Edriss, & Sukop, 2013;Mestak & Zimovjanová, 2012;Ruan et al, 2019;Russe et al, 2015;Sforza, Andjelkov, Zaccheddu, Husein, & Atkinson, 2016;Wang et al, 2012), 5 to osteoarthritis (4 of the knee and 1 of the hip) (Barfod & Blønd, 2019;Dall'Oca et al, 2019;Jones et al, 2018;Panchal, Malanga, & Sheinkop, 2018;Schiavone Panni et al, 2019), 3 to complex anal fistula (Laureti et al, 2020;Naldini, Sturiale, Fabiani, Giani, & Menconi, 2018;Topal, Eray, Rencüzo gulları, Yalav, & Alabaz, 2019), whereas 8 studies concern different pathologies (Casarotti, Chiodera, & Tremolada, 2018;Cestaro, De Rosa, Massa, Amato, & Gentile, 2015;Cherian, Malanga, Hogaboom, Pollack, & Dyson-Hudson, 2019;Hirahara, Andersen, & Panero, 2017;Kuka et al, 2020;Lonardi et al, 2019;Saibene, Pipolo, Lorusso, Portaleone, & Felisati, 2015;Zuin et al, 2019). The interesting fact is that all the aforementioned devices are mainly used for breast reconstructions, exc...…”