Preliminary Results on the Feasibility of Using ARFI/SWEI to Assess Cutaneous Sclerotic Diseases

Lee, Seung Yun; Cardones, Adela R.; Doherty, Joshua R.; Nightingale, Kathryn R.; Palmeri, Mark L.

doi:10.1016/j.ultrasmedbio.2015.06.007

Cited by 53 publications

(39 citation statements)

References 33 publications

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“…Normalized SWV was used by equation when comparing matched control sites. The equation was as follows:

Cn = Cm \cdot \frac{Hc}{Hs}

, where Cn was normalized mean SWV, Cm was measured mean SWV, Hc was the height of matched control healthy skin and Hs was the height of the sclerotic skin.…”

Section: Methodsmentioning

confidence: 99%

“…VTIQ has a smaller shear wave region of interest (SW‐ROI) (1 mm × 1 mm) than that of VTQ and may be suitable for skin tissue. Because of the advantage of shear wave elastography (SWE) in quantity, some research has reported that SWV could assess cutaneous sclerotic diseases including LS and SWV could differentiate sclerotic lesions from normal dermis . According to the recently clinical diagnostic criteria, the diagnosis and stage of LS is varied even by pathological results .…”

Section: Introductionmentioning

confidence: 99%

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Comparison of 2‐D shear wave elastography with clinical score in localized scleroderma: A new method to increase the diagnostic accuracy

Wang

Shan

Chen

et al. 2018

The Journal of Dermatology

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There is no established diagnostic criteria or widely accepted severity classification of localized scleroderma (LS) by imaging. Acoustic radiation force impulse (ARFI) technology by normalized mean shear wave velocity (SWV) may be as a probing tool for diagnosing and staging LS accurately and objectively. Fifty‐six patients with LS of inflammatory (n = 21), sclerotic (n = 24) and atrophic (n = 11) stage and 30 healthy controls were evaluated on the basis of pathological results. Dermal thickness, ARFI quality (elastography score) and quantity (mean SWV) were measured by ultrasonography (US), diagnosis and stage performances of LS using the dermal thickness, elastography score and mean SWV compared with modified localized scleroderma skin severity index (mLoSSI) were evaluated. Significant differences in the dermal thickness, elastography score and mean SWV were found between the normal adult and LS patients; for diagnosing LS, the area under the receiver–operator curves (AUROC) of the dermal thickness, elastography score, mean SWV and mLoSSI were 0.93 ± 0.03, 0.95 ± 0.01, 0.93 ± 0.03 and 0.93 ± 0.02, respectively. Compared with the dermal thickness, the elastography score and mLoSSI, the AUROC and the specificities of mean SWV for differentiating sclerotic from inflammatory stage and atrophic from sclerotic LS increased significantly, especially by normalized mean SWV (AUROC, 0.84 ± 0.06 and 0.83 ± 0.07; specificity, 85.71% and 91.67%). As non‐invasive methods, mean SWV and dermal thickness by US may provide reliable information to diagnose and stage LS compared with mLoSSI especially by normalized mean SWV.

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“…Normalized SWV was used by equation when comparing matched control sites. The equation was as follows:

Cn = Cm \cdot \frac{Hc}{Hs}

, where Cn was normalized mean SWV, Cm was measured mean SWV, Hc was the height of matched control healthy skin and Hs was the height of the sclerotic skin.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of 2‐D shear wave elastography with clinical score in localized scleroderma: A new method to increase the diagnostic accuracy

Wang

Shan

Chen

et al. 2018

The Journal of Dermatology

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“…Previous studies verifying elastography as a method to examine skin pathologies involved primarily cancer patients [23][24][25][26][27] and individuals with chronic systemic inflammation [28][29][30][31][32][33][34][35][36]. Most of these studies confirmed that elastography is an accurate method to identify and quantify proliferative and fibrotic processes taking place in the skin.…”

Section: Application Of Elastography In Dermatologymentioning

confidence: 86%

Ultrasonographic elastography in the evaluation of normal and pathological skin – a review

Ambroziak

Pietruski²,

Noszczyk³

et al. 2019

pdia

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A b s t r a c tThe aim of this review article is to discuss the role of ultrasonographic elastography, a technique used to quantify tissue stiffness, in the evaluation of normal and pathological skin. A growing body of evidence suggests that elastography may be used for the diagnosis and monitoring of skin pathologies, in particular tumors, and fibrotic and sclerotic processes. Our knowledge about the elastographic parameters of normal skin is sparse, which together with the lack of reference values for cutaneous stiffness constitutes a serious limitation to the use of elastography in some medical disciplines, including aesthetic medicine.

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“…The changes in ECM content during scaring make tissue stiffness amenable to being characterised with acoustic imaging, such as Acoustic Radiation Force Impulse (ARFI) and Shear Wave Elasticity Imaging (SWEI), to portray information regarding the stiffness of the target tissue . This advancement has allowed progressive tissue stiffness to be evaluated non‐invasively, serving as a valuable tool in the clinical understanding of progressive tension and maladaptive wound repair …”

Section: Mechanobiology Of Cutaneous Scarring and Mechanotherapymentioning

confidence: 99%

The tension biology of wound healing

Harn

Ogawa

Hsu

et al. 2017

Experimental Dermatology

147

110

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Following skin wounding, the healing outcome can be: regeneration, repair with normal scar tissue, repair with hypertrophic scar tissue or the formation of keloids. The role of chemical factors in wound healing has been extensively explored, and while there is evidence suggesting the role of mechanical forces, its influence is much less well defined. Here, we provide a brief review on the recent progress of the role of mechanical force in skin wound healing by comparing laboratory mice, African spiny mice, fetal wound healing and adult scar keloid formation. A comparison across different species may provide insight into key regulators. Interestingly, some findings suggest tension can induce an immune response, and this provides a new link between mechanical and chemical forces. Clinically, manipulating skin tension has been demonstrated to be effective for scar prevention and treatment, but not for tissue regeneration. Utilising this knowledge, specialists may modulate regulatory factors and develop therapeutic strategies to reduce scar formation and promote regeneration. K E Y W O R D Smechanobiology, regeneration, scar, tension, wound

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Preliminary Results on the Feasibility of Using ARFI/SWEI to Assess Cutaneous Sclerotic Diseases

Cited by 53 publications

References 33 publications

Comparison of 2‐D shear wave elastography with clinical score in localized scleroderma: A new method to increase the diagnostic accuracy

Comparison of 2‐D shear wave elastography with clinical score in localized scleroderma: A new method to increase the diagnostic accuracy

Ultrasonographic elastography in the evaluation of normal and pathological skin – a review

The tension biology of wound healing

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