Preliminary Results that Assess Metformin Treatment in a Preclinical Model of Pancreatic Cancer Using Simultaneous [18F]FDG PET and acidoCEST MRI

Goldenberg, Joshua M.; Cárdenas-Rodríguez, Julio; Pagel, Mark

doi:10.1007/s11307-018-1164-4

Cited by 32 publications

(33 citation statements)

References 35 publications

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“…Therefore, combining 18 FDG PET and acidoCEST MRI during a simultaneous PET/MRI scan session has strong merit for evaluating tumor metabolism from complimentary perspectives with a practical methodology. This type of PET/MRI study has recently been accomplished with tumor models, first by showing the feasibility of performing sequential 18 FDG PET and acidoCEST MRI with two instruments, and then performing simultaneous 18 FDG PET/acidoCEST MRI with a single instrument (Figure ) . The more comprehensive assessment of the glycolysis pathway was useful for evaluating the regionality of upregulated glycolysis in tumor tissue, and for evaluating the effects of metformin treatment on tumor metabolism.…”

Section: Combining Cest Mri With Other Molecular Imaging Methodsmentioning

confidence: 99%

“…Parametric maps of iopamidol concentration and extracellular pH in the tumor are overlaid on an anatomical MR image. Reproduced with permission from Reference …”

Section: Combining Cest Mri With Other Molecular Imaging Methodsmentioning

confidence: 99%

“…This pulse thereby saturates the net magnetization of the pool of labile protons. Physical exchange of these protons with protons on water molecules transfers their reduced magnetization to water, decreasing the net water signal that is detected using standard MRI acquisition methods (Figure ) . This process of selective saturation can be repeated over a range of saturation frequencies, and a plot of MRI signal amplitude relative to saturation frequency generates a CEST spectrum (also known as a Z ‐spectrum because this spectrum represents net coherent Z ‐magnetization after applying the saturation pulse) .…”

Section: The Cest Mri Mechanismmentioning

confidence: 99%

“…C‐F, MR images of water signal in a tube of 20 mM iopamidol in a larger tube of water, with saturation applied at 9.5, 5.6, 4.2, and 0 ppm. Reproduced with permission from Reference …”

Section: The Cest Mri Mechanismmentioning

confidence: 99%

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Assessments of tumor metabolism with CEST MRI

Goldenberg

Pagel

2018

NMR in Biomedicine

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Chemical exchange saturation transfer (CEST) is a relatively new contrast mechanism for MRI. CEST MRI exploits a specific MR frequency (chemical shift) of a molecule while generating an image with good spatial resolution using standard MRI techniques, combining the specificity of MRS with the spatial resolution of MRI. Many CEST MRI acquisition methods have been developed to improve analyses of tumor metabolism. GluCEST, CrCEST, and LATEST can map glutamate, creatine, and lactate, which are important metabolites involved in tumor metabolism. GlucoCEST MRI tracks the pharmacokinetics of glucose transport and cell internalization within tumors. CatalyCEST MRI detects enzyme catalysis that changes a substrate CEST agent. AcidoCEST MRI measures extracellular pH of the tumor microenvironment by exploiting a ratio of two pH-dependent CEST signals. This review describes each technique, the technical issues involved with CEST MRI and each specific technique, and the merits and challenges associated with applying each CEST MRI technique to study tumor metabolism.

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Section: Combining Cest Mri With Other Molecular Imaging Methodsmentioning

confidence: 99%

“…Parametric maps of iopamidol concentration and extracellular pH in the tumor are overlaid on an anatomical MR image. Reproduced with permission from Reference …”

Section: Combining Cest Mri With Other Molecular Imaging Methodsmentioning

confidence: 99%

Section: The Cest Mri Mechanismmentioning

confidence: 99%

“…C‐F, MR images of water signal in a tube of 20 mM iopamidol in a larger tube of water, with saturation applied at 9.5, 5.6, 4.2, and 0 ppm. Reproduced with permission from Reference …”

Section: The Cest Mri Mechanismmentioning

confidence: 99%

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Assessments of tumor metabolism with CEST MRI

Goldenberg

Pagel

2018

NMR in Biomedicine

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“…In addition, it provided evidence of the feasibility of measuring tumor pH heterogeneity at the clinical field of 3T (Figures 2A,B). The combination of CEST pH-imaging and FDG-PET was then exploited for predicting the early therapeutic efficacy of metformin in a preclinical model of pancreatic cancer (98). In addition, the possibility to measure tumor pHe opened new routes for monitoring the effect of novel anticancer treatments that can reverse the glycolytic tumor phenotype (97).…”

Section: Extracellular Tumor Ph Imagingmentioning

confidence: 99%

Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging

Consolino¹,

Anemone²,

Capozza³

et al. 2020

Front. Oncol.

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Altered metabolism is considered a core hallmark of cancer. By monitoring in vivo metabolites changes or characterizing the tumor microenvironment, non-invasive imaging approaches play a fundamental role in elucidating several aspects of tumor biology. Within the magnetic resonance imaging (MRI) modality, the chemical exchange saturation transfer (CEST) approach has emerged as a new technique that provides high spatial resolution and sensitivity for in vivo imaging of tumor metabolism and acidosis. This mini-review describes CEST-based methods to non-invasively investigate tumor metabolism and important metabolites involved, such as glucose and lactate, as well as measurement of tumor acidosis. Approaches that have been exploited to assess response to anticancer therapies will also be reported for each specific technique.

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Evaluation of a similarity anisotropic diffusion denoising approach for improving in vivo CEST‐MRI tumor pH imaging

Romdhane

Villano

Irrera

et al. 2021

Magnetic Resonance in Med

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Purpose: Chemical exchange saturation transfer MRI provides new approaches for investigating tumor microenvironment, including tumor acidosis that plays a key role in tumor progression and resistance to therapy. Following iopamidol injection, the detection of the contrast agent inside the tumor tissue allows measurements of tumor extracellular pH. However, accurate tumor pH quantifications are hampered by the low contrast efficiency of the CEST technique and by the low SNR of the acquired CEST images, hence in a reduced detectability of the injected agent. This work aims to investigate a novel denoising method for improving both tumor pH quantification and accuracy of CEST-MRI pH imaging. Methods: An hybrid denoising approach was investigated for CEST-MRI pH imaging based on the combination of the nonlocal mean filter and the anisotropic diffusion tensor method. The denoising approach was tested in simulated and in vitro data and compared with previously reported methods for CEST imaging and with established denoising approaches. Finally, it was validated with in vivo data to improve the accuracy of tumor pH maps. Results: The proposed method outperforms current denoising methods in CEST contrast quantification and detection of the administered contrast agent at several increasing noise levels with simulated data. In addition, it achieved a better pH quantification in in vitro data and demonstrated a marked improvement in contrast detection and a substantial improvement in tumor pH accuracy in in vivo data. Conclusion: The proposed approach effectively reduces the noise in CEST images and increases the sensitivity detection in CEST-MRI pH imaging.

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Preliminary Results that Assess Metformin Treatment in a Preclinical Model of Pancreatic Cancer Using Simultaneous [18F]FDG PET and acidoCEST MRI

Cited by 32 publications

References 35 publications

Assessments of tumor metabolism with CEST MRI

Assessments of tumor metabolism with CEST MRI

Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging

Evaluation of a similarity anisotropic diffusion denoising approach for improving in vivo CEST‐MRI tumor pH imaging

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