Preliminary studies for a new antibiotic from the marine mollusk Melo melo (Lightfoot, 1786)

Sivasubramanian, Kanagasabapathy; Ravichandran, S.; Kumaresan, M.

doi:10.1016/s1995-7645(11)60092-8

Cited by 17 publications

(8 citation statements)

References 10 publications

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“…The extract of the marine mollusk Melo melo exhibited maximum antifungal activity against Trichophyton mentagarophytes and minimum activity against Aspergillus flavus (Kanagasabapathy et al 2011). …”

Section: Antifungal Productsmentioning

confidence: 99%

Antifungal and antiviral products of marine organisms

Cheung

Wong

Pan

et al. 2014

Appl Microbiol Biotechnol

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Marine organisms including bacteria, fungi, algae, sponges, echinoderms, mollusks, and cephalochordates produce a variety of products with antifungal activity including bacterial chitinases, lipopeptides, and lactones; fungal (−)-sclerotiorin and peptaibols, purpurides B and C, berkedrimane B and purpuride; algal gambieric acids A and B, phlorotannins; 3,5-dibromo-2-(3,5-dibromo-2-methoxyphenoxy)phenol, spongistatin 1, eurysterols A and B, nortetillapyrone, bromotyrosine alkaloids, bis-indole alkaloid, ageloxime B and (−)-ageloxime D, haliscosamine, hamigeran G, hippolachnin A from sponges; echinoderm triterpene glycosides and alkene sulfates; molluscan kahalalide F and a 1485-Da peptide with a sequence SRSELIVHQR; and cepalochordate chitotriosidase and a 5026.9-Da antifungal peptide. The antiviral compounds from marine organisms include bacterial polysaccharide and furan-2-yl acetate; fungal macrolide, purpurester A, purpurquinone B, isoindolone derivatives, alterporriol Q, tetrahydroaltersolanol C and asperterrestide A, algal diterpenes, xylogalactofucan, alginic acid, glycolipid sulfoquinovosyldiacylglycerol, sulfated polysaccharide p-KG03, meroditerpenoids, methyl ester derivative of vatomaric acid, lectins, polysaccharides, tannins, cnidarian zoanthoxanthin alkaloids, norditerpenoid and capilloquinol; crustacean antilipopolysaccharide factors, molluscan hemocyanin; echinoderm triterpenoid glycosides; tunicate didemnin B, tamandarins A and B and; tilapia hepcidin 1–5 (TH 1–5), seabream SauMx1, SauMx2, and SauMx3, and orange-spotted grouper β-defensin. Although the mechanisms of antifungal and antiviral activities of only some of the afore-mentioned compounds have been elucidated, the possibility to use those known to have distinctly different mechanisms, good bioavailability, and minimal toxicity in combination therapy remains to be investigated. It is also worthwhile to test the marine antimicrobials for possible synergism with existing drugs. The prospects of employing them in clinical practice are promising in view of the wealth of these compounds from marine organisms. The compounds may also be used in agriculture and the food industry.

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Section: Antifungal Productsmentioning

confidence: 99%

Antifungal and antiviral products of marine organisms

Cheung

Wong

Pan

et al. 2014

Appl Microbiol Biotechnol

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“…Mollusca is widely acknowledged as the second most taxonomically diverse phylum in the animal kingdom, encompassing over 85,000 distinct species that have been classified into 8 distinct classes [ 125 , 126 ]. Additionally, it comprises the most extensive assemblage of biologically toxic invertebrates, inhabiting various ecological niches, including marine, freshwater, and terrestrial ecosystems [ 125 , 127 ]. The remarkable capacity for adaptation exhibited by these organisms implies the presence of a highly efficient biosynthetic pathway responsible for the synthesis of a wide range of bioactive compounds.…”

Section: Marine Mollusksmentioning

confidence: 99%

Marine-Derived Anticancer Agents Targeting Apoptotic Pathways: Exploring the Depths for Novel Cancer Therapies

Dalisay,

Tenebro,

Sabido

et al. 2024

Marine Drugs

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Extensive research has been conducted on the isolation and study of bioactive compounds derived from marine sources. Several natural products have demonstrated potential as inducers of apoptosis and are currently under investigation in clinical trials. These marine-derived compounds selectively interact with extrinsic and intrinsic apoptotic pathways using a variety of molecular mechanisms, resulting in cell shrinkage, chromatin condensation, cytoplasmic blebs, apoptotic bodies, and phagocytosis by adjacent parenchymal cells, neoplastic cells, or macrophages. Numerous marine-derived compounds are currently undergoing rigorous examination for their potential application in cancer therapy. This review examines a total of 21 marine-derived compounds, along with their synthetic derivatives, sourced from marine organisms such as sponges, corals, tunicates, mollusks, ascidians, algae, cyanobacteria, fungi, and actinobacteria. These compounds are currently undergoing preclinical and clinical trials to evaluate their potential as apoptosis inducers for the treatment of different types of cancer. This review further examined the compound’s properties and mode of action, preclinical investigations, clinical trial studies on single or combination therapy, and the prospective development of marine-derived anticancer therapies.

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“…The majority of marine organisms fend off a wide range of microorganisms by producing antimicrobial peptides (AMPs). Bioactive peptides isolated from marine molluscs specifically those isolated from bivalves and abalone, have displayed potent antimicrobial efficacy [37,51]. A saccharothrixmicine peptide with antimicrobial activity against Candida albicans and Xanthomonas sp was isolated from the marine mollusc Anadara broughtoni in association with Saccharothrix espanaensis AN 113 [37,52].…”

Section: Antimicrobial Peptidesmentioning

confidence: 99%

Bioactive Peptides from Marine Molluscs – A Review

Eghianruwa¹,

Osoniyi

Maina³

et al. 2019

IJBcRR

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Marine organisms make up approximately half of the total global biodiversity, with the Mollusca containing the second largest number of species, including snails and bivalves. The marine environment is highly competitive, hostile and aggressive, which has led to the production of specific and potent bioactive compounds by the mollusca and their associated microorganisms, in a bid to protect themselves and ensure their survival. A diverse array of bioactive compounds can be isolated from the extracts of marine molluscs of which linear, cyclic, and conjugated peptides and depsipeptides form some of the most important bioactive compounds that have been well characterized and some of have already reached clinical trials or been approved for use as therapeutic agents and supplements. This review highlights some of the bioactive peptides that have been obtained from marine molluscs as well the challenges facing bioprospecting of valuable peptides from marine mollusc sources.

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Preliminary studies for a new antibiotic from the marine mollusk Melo melo (Lightfoot, 1786)

Abstract: The extracts from marine mollusks M. melo is the potential source of producing bioactive compounds against human pathogens and can be used for synthesis of new drugs.

Cited by 17 publications

References 10 publications

Antifungal and antiviral products of marine organisms

Antifungal and antiviral products of marine organisms

Marine-Derived Anticancer Agents Targeting Apoptotic Pathways: Exploring the Depths for Novel Cancer Therapies

Bioactive Peptides from Marine Molluscs – A Review

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