Preliminary studies into the effects of the human pharmaceutical Clofibric acid on sperm parameters in adult Fathead minnow

Runnalls, Tamsin J.; Hala, David; Sumpter, John P.

doi:10.1016/j.aquatox.2007.06.005

Cited by 77 publications

(50 citation statements)

References 27 publications

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“…Rotifers have also shown to be sensitive and a NOEC 6 value of 250 µg L −1 was deduced [96]. Fathead minnow fish (Pimephales promelas) showed alterations in reproductive function expressed by a reduction in sperm motility and plasma androgen concentration [117] while cytological changes in gills were noticed in rainbow trout exposed to 5 µg L −1 of this metabolite [97]. Fibrates (as bezafibrate and gemfibrozil) have been detected in several environmental samples (Table 2).…”

Section: Blood Lipid Lowering Agentsmentioning

confidence: 99%

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos

Araújo

Fachini

et al. 2010

Journal of Hazardous Materials

1,302

533

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Pharmaceuticals are biologically active and persistent substances which have been recognized as a con-tinuing threat to environmental stability. Chronic ecotoxicity data as well as information on the current distribution levels in different environmental compartments continue to be sparse and are focused on those therapeutic classes that are more frequently prescribed and consumed. Nevertheless, they indicate the negative impact that these chemical contaminants may have on living organisms, ecosystems and ultimately, public health. This article reviews the different contamination sources as well as fate and both acute and chronic effects on nontarget organisms. An extensive review of existing data in the form of tables, encompassing many therapeutic classes is presented.Keywords: Pharmaceuticals, Sources, Environmental fate, Ecotoxicological effects

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Section: Blood Lipid Lowering Agentsmentioning

confidence: 99%

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos

Araújo

Fachini

et al. 2010

Journal of Hazardous Materials

1,302

533

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confidence: 99%

“…However, the ability of freshwater teleost sperm to become motile after ejaculation, a crucial link to the reproductive success in a mating event, has received less attention (Kime 1999;Kime and Nash 1999). While research has more often focused on semen and sperm quality of exposed male fish (Schoenfuss et al 2002;Lahnsteiner et al 2005a, b;Runnalls et al 2007); recently, several studies have examined the effects of pollutants in effluent on motility parameters of fish sperm (Kime et al 1996;Rurangwa et al 2002). These studies, in effect, treated sperm as an independent, short-lived organism (often \ 1 min) that can be affected by effluent independently of the organism from which it originated.…”

mentioning

confidence: 99%

Treated Wastewater Effluent Reduces Sperm Motility Along an Osmolality Gradient

Schoenfuss

Levitt²,

Rai

et al. 2008

Arch Environ Contam Toxicol

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Many toxic effects of treated wastewater effluent on organismal and reproductive health have been documented. However, the physicochemical environment of treated wastewater effluent frequently differs considerably from that of its receiving waters and may affect organismal function independently of toxic effects. Teleost sperm, for example, may be affected by the higher osmolality of treated wastewater, as this sperm is activated for a brief period of time following ejaculation due to the sudden decrease in osmolality of its surrounding environment. In this study, we examined the effects of treated wastewater effluent on sperm motility to test the hypothesis that the higher osmolality of effluent compared to river water will adversely affect sperm activation in a concentrationdependent relationship. Treated wastewater effluent was collected on 5 days from the outflow of the Metropolitan Wastewater Treatment Plant, St. Paul, Minnesota, and from an upstream site on the Mississippi River. Milt aliquots collected from goldfish were diluted in an isotonic extender solution and subsequently activated in either deionized water, 100%, 50%, or 10% effluent, a synthetic ion mixture, or river water. Sperm motility and velocity were assessed at 15-s intervals for 1 min using a computer assisted sperm analyzer. Significant differences in performance parameters were found only at 15 s, with sperm motility and velocity declining rapidly at later sampling times. Predictably, deionized water resulted in the greatest activation of sperm motility, while motility exhibited a concentration-dependent decline in 10%, 50%, and 100% treated wastewater effluent. Interestingly, Mississippi River water and a synthetic ion mixture with an osmolality comparable to 50% effluent both resulted in the least amount of sperm activation. However, sperm activation in river water varied between collection days during the study. River water and 100% effluent both had low sperm activation characteristics despite a 10-fold difference in osmolality between these two treatments (1 and 10 mOsmol kg -1 , respectively). Results of this study indicate a concentration-dependent decrease in sperm motility in treated wastewater effluent as well as significant fluctuations of sperm activation in Mississippi River water. This study illustrates the complexity of assessing the effects of treated wastewater effluents and the difficulty of determining appropriate reference sites for such studies.Many effects of treated wastewater effluent on the reproductive ability of fish have been examined. However, the ability of freshwater teleost sperm to become motile after ejaculation, a crucial link to the reproductive success in a mating event, has received less attention (Kime 1999;Kime and Nash 1999). While research has more often focused on semen and sperm quality of exposed male fish (Schoenfuss et al. 2002;Lahnsteiner et al. 2005a, b;Runnalls et al.

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“…Among the observed effects, there are: reduction in growth, sperm count, egg production, and reproduction; sexual disruption; inhibition of settlement of larvae; disruption in mitochondrial function, intestine, and immune systems; impaired spermatogenesis; disruption in energy metabolism; cytotoxicity in liver, kidney, and gills; oxidative stress in membrane cells; changes in appetite (Webb, 2001;Jobling et al, 2002Jobling et al, , 2006Cleuvers, 2003Cleuvers, , 2004Thorpe et al, 2003;Schwaiger et al, 2004;Triebskorn et al, 2004;Hoeger et al, 2005;Caminada et al, 2006;Crane et al, 2006;Fent et al, 2006;Filby et al, 2007;Flippin et al, 2007;Johnston et al, 2007;Kim et al, 2007;Owen et al, 2007;Runnalls et al, 2007;Shved et al, 2008;Christen et al, 2010;Corcoran et al, 2010;Nassef et al, 2010;Santos et al, 2010;Cuthbert et al, 2011). As far as ecosystems are concerned, effects may include a decline in biodiversity at different trophic levels such as bacteria, algae, zooplankton, fish, crustaceans, and invertebrates.…”

Section: Introductionmentioning

confidence: 99%

“…Adverse effects of pharmaceuticals to fish and aquatic life are typically detected in aquatic ecosystems (Grondel et al, 1985;Wishkovsky et al, 1987;Vos et al, 2000;Arukwe, 2001;Jobling et al, 2002Jobling et al, , 2006Cleuvers, 2003Cleuvers, , 2004; Thorpe et al, 2003;Brooks et al, 2003Brooks et al, , 2005Schwaiger et al, 2004;Triebskorn et al, 2004;Hoeger et al, 2005;Flippin et al, 2007;Oaks et al, 2004;Caminada et al, 2006;Cunningham et al, 2006;Fent et al, 2006;Filby et al, 2007;Flippin et al, 2007;Johnston et al, 2007;Kim et al, 2007;Owen et al, 2007;Runnalls et al, 2007;Shved et al, 2008;Christen et al, 2010;Corcoran et al, 2010;Nassef et al, 2010;Santos et al, 2010;Cuthbert et al, 2011). Adverse effects include for instance the production of reactive oxygen species in fish (Gonzalez et al, 1998;Laville et al, 2004;Fent et al, 2006;Mostofa et al, 2013aMostofa et al, , 2013b.…”

Section: Introductionmentioning

confidence: 99%

Sources, factors, mechanisms and possible solutions to pollutants in marine ecosystems

Mostofa

Liu

Vione

et al. 2013

Environmental Pollution

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. Sources, factors, mechanisms and possible solutions to pollutants in marine ecosystems. Environ. Pollut. 2013, 182, 461-478. DOI: 10.1016/j.envpol.2013 You may download, copy and otherwise use the AAM for non-commercial purposes provided that your license is limited by the following restrictions:(1) You may use this AAM for non-commercial purposes only under the terms of the CC-BY-NC-ND license.(2) The integrity of the work and identification of the author, copyright owner, and publisher must be preserved in any copy.(3) You must attribute this AAM in the following format: habitats during the breeding period of marine species, usually for few days; and (ii) in some specific marine locations that have high biodiversity and target and non-target ecosystem components. Possible remedial measures are assessed, but their effective coming into force strongly depends on the public awareness of existing problems and on the priority level that such problems will reach in policy making.

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Preliminary studies into the effects of the human pharmaceutical Clofibric acid on sperm parameters in adult Fathead minnow

Cited by 77 publications

References 27 publications

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Treated Wastewater Effluent Reduces Sperm Motility Along an Osmolality Gradient

Sources, factors, mechanisms and possible solutions to pollutants in marine ecosystems

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