Background: Termites (Order Isoptera) are eusocial insects that are of great benefit and economic importance to humans. Despite its benefits and economic attributes to humans, it accounts for serious damage on buildings in Nigeria especially in the rural areas. The aim of this study was to collect preliminary data on termite infestation of the buildings in Ase, a local community in the Niger Delta region of Nigeria. Data was collected by direct observation of termites on the buildings, and a structured questionnaire was presented to respondents in houses with visual signs of infestation. Samples of termites were collected from parts of the houses with mud tubes or nests. Results: A total of 106 houses were inspected with 35.85% infested with termites. The termites found were two species of Amitermes, one of Microcerotermes, three of Nasutitermes, two of Neotermes, and one of Odontotermes. Most infested homes (71%) were graded as moderate, severely damaged, and collapsed revealing a major problem. Percentage infestation of wood services revealed door frames 62.5% and wall (mud tubes) 87.75%, floor 18.85%, logs outside the house 56.25%, windows and roof 43.75%, ceiling 18.75%, and bathroom, furniture, and kitchen 6. 25%. Respondents were 30-90 years old and did not attribute mud tubes to termite infestation. Seventy-two percent of the buildings were less than 60 years, and preventive measures used by respondents were Solignum and used engine oil. Most of the buildings were severely infested, and a < 2-year-old house showed visible signs of slight termite infestation. Conclusion: This study clearly demonstrates the level of termite infestation in Ase and the need for better control measures and increased awareness for early detection.