Preliminary studies on the inhibitory effect of novel Pd(II) complexes of vitamin B6 on cell divisions

Moussa, N.M.; Laham, Amina Jamal; El-Ezaby, Mohamed S.; Al-Salem, Najeeb A.; Abu‐Zeid, M. E.; Mahmoud, Gharib S.; Kabarity, A.; Mazrooei, S.

doi:10.1016/s0162-0134(00)80098-7

Cited by 18 publications

(3 citation statements)

References 17 publications

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“…This study demonstrates that pharmacological doses of pyridoxal phosphate, the biologically active form of vitamin B6, inhibits rodent pituitary tumor cell proliferation, consistent with literature reports of pyridoxine-induced anti-proliferative effects on other tumor cells (4)(5)(6)(7)(8)(9)(10)(11)(12). This effect was not caused by necrosis or potential toxic action of pyridoxine at high doses, because cell numbers were not significantly changed at the end of 7 days of exposure to 1 mM PLP, and cell growth recovered to normal levels after PLP withdrawal.…”

Section: Discussionsupporting

confidence: 90%

“…Patients with breast (4), or colon (5,6), bladder (7), or laryngeal (8) cancers, and or Hodgkin's disease (1) have lower plasma PLP levels compared with healthy controls. In vitro studies have shown that pharmacologic doses of vitamin B6 (from 0.25 to 5 mM) inhibit cell proliferation and protein synthesis in HepG2 human hepatoma cells (9), human malignant melanoma (10,11), and human lymphocytes (12). Mice pretreated with pyridoxal followed by injection of B16 melanoma cells had a 62% reduction in tumor weight compared to controls (11).…”

Section: Introductionmentioning

confidence: 99%

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Pyridoxal Phosphate Inhibits Pituitary Cell Proliferation and Hormone Secretion

Ren

Melmed

2006

Endocrinology

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Pyridoxal phosphate (PLP), a bioactive form of pyridoxine, dose-dependently (10-1000 microm) inhibited cell proliferation in rat pituitary MMQ and GH3 cells and in mouse AtT-20 cells. After 4 d, MMQ cell numbers were reduced by up to 81%, GH3 cell numbers were reduced by up to 64% (P < 0.05), and AtT-20 cell numbers were reduced by up to 90%. Cell proliferation rates recovered and dose-dependently reverted to control levels after PLP withdrawal. After 4 d, PLP (400 and 1000 microm) decreased [3H]thymidine incorporation by up to 71% (P < 0.05). PLP (400-1000 microm) reduced GH3 cell GH and prolactin secretion and AtT-20 cell ACTH secretion (adjusted for cell number) by approximately 70% after 2 d. The 100 microm PLP also inhibited prolactin secretion (65%, P < 0.05) in primary rat pituitary cells treated for 2 d. PLP decreased the percentage of AtT-20 and GH3 cells in S phase and increased those in G0-G1 phase. Furthermore, PLP induced AtT-20 and GH3 cell apoptosis (28 vs. 6, P < 0.05; 26 vs. 3, P < 0.05, respectively) and dose-dependently reduced content of the antiapoptosis gene Bcl-2. These results indicate that pharmacological doses of PLP inhibit pituitary cell proliferation and hormone secretion, in part mediated through PLP-induced cell-cycle arrest and apoptosis. Pyridoxine may therefore be appropriate for testing as a relatively safe drug for adjuvant treatment of hormone-secreting pituitary adenomas.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Pyridoxal Phosphate Inhibits Pituitary Cell Proliferation and Hormone Secretion

Ren

Melmed

2006

Endocrinology

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“…This result may confirm the finding stated by Moussa et al (1982) in which they found that complex (I) alone caused inhibition in the rate of division, while ethionine and complex (I) compensate each other permitting the lymphocytes to divide normal ly as in untreated cells.…”

supporting

confidence: 90%

The combined effects of ethionine, adenine and Pd (II) complexes of vitamin B6 on cell division.

Moussa¹,

Kabarity²,

Mazrooei

et al. 1985

CYTOLOGIA

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Accelerated degradation of poly(vinyl chloride) (PVC) monitored by photoacoustic spectroscopy

Abu‐Zeid

Nofal

Marafi

et al. 1984

J of Applied Polymer Sci

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synopsisPoly(viny1 chloride) film shows substantial changes in its photoacoustic absorption spectra (PAS) on either irradiation or heating in the presence of O2 or NP These spectral changes are due to the conjugation structures and carbonyl (group formation), formed during photo-and thermal degradation. In this paper interpretations of the PAS and of the decomposition mechanism of PVC are presented.

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Preliminary studies on the inhibitory effect of novel Pd(II) complexes of vitamin B6 on cell divisions

Cited by 18 publications

References 17 publications

Pyridoxal Phosphate Inhibits Pituitary Cell Proliferation and Hormone Secretion

Pyridoxal Phosphate Inhibits Pituitary Cell Proliferation and Hormone Secretion

The combined effects of ethionine, adenine and Pd (II) complexes of vitamin B6 on cell division.

Accelerated degradation of poly(vinyl chloride) (PVC) monitored by photoacoustic spectroscopy

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