Preliminary study of chemical bile duct embolization to treat hepatolithiasis in rabbits

Abstract

Chemical bile duct embolization is a promising approach to prevent the recurrence of hepatolithiasis and to achieve the effect of chemical hepatectomy.

Proliferating cell nuclear antigen shRNA treatment attenuates chronic proliferative cholangitis in rats

“…With a deeper understanding of pathological changes in hepatolithiasis in recent years, the high stone recurrence and biliary restenosis rate have been confirmed to be due to postoperatively‐remnant CPC 5,11,12 . As we know, CPC is associated with approximately 75% of hepatolithiasis cases in Asia and plays a significant role in the pathogenesis of hepatolithiasis 7,14,17 . First, the papillary hyperplasia in the biliary mucosa and fibrous thickening in the biliary duct wall result in the deformation and obstruction of the bile duct lumen, ultimately leading to the formation of intrahepatic calculi 5,15 .…”

“…However, our research is only a preliminary animal investigation of this potential method in preventing stone recurrence and biliary restenosis. Further research on its long‐term effectiveness, relevant complications, and application approaches remain to be performed before its clinical application 7–10,21–25 …”

Chemical bile duct embolization for chemical hepatectomy, long term efficacy and feasibility in rats

“…In previous study, we explored the feasibility and efficacy of filling the diseased bile duct with chemical embolization agent to achieve chemical resection of the diseased bile duct and hepatic segment, and was able to establish the effects of chemical hepatectomy only in the periphery of the targeted hepatic lobe. [11][12][13][14][15] This study focuses on whether CBDE in the long-term manages to achieve complete fibrosis, "self-cut" and chemical hepatectomy in the whole embolized hepatic lobe.…”

“…This kind of visibility makes CBDE much safer, easier and more accurate in its application. 5,11,12,15,[23][24][25] The mechanism underlying chemical hepatectomy via CBDE may involve the following aspects. The embolized bile duct obviously distends and compresses the adjacent blood vessels, thus reducing the blood supply to the embolized hepatic lobe.…”

“…However, hepatic atrophy, fibrosis, and "self-cut" phenomenon was only achieved in the peripheral region of the targeted hepatic lobe. 5,[10][11][12][13][14][15] It is still unknown whether hepatic atrophy, fibrosis and "self-cut" phenomenon can be achieved in the whole embolized lobe by CBDE in a longer period of time. Thus, this study was designed to differentiate and explore the efficacy and feasibility of the short-term (6 weeks) and long-term (12 weeks) effects of CBDE to achieve the desired effect of chemical hepatectomy ("self-cut") in the whole targeted hepatic lobe.…”