The development of learning technology in industry 4.0 in the last few years was growing rapidly one of which was a virtual application. One of the virtual learning applications developed was a virtual laboratory. The use of virtual laboratories in Revolution 4.0 was very useful especially educational institutions that did not have enough space and equipment. Virtual laboratory research had been carried out in recent years. The development of virtual laboratories developed was the media, models, and materials in virtual laboratories. The existing virtual laboratory was one-way learning. Virtual laboratories had no feedback with users especially the desires and abilities of users in virtual laboratories. Laboratory learning based on user desires and abilities as needed. This learning model was known as personalization. This research developed a virtual laboratory that was personalized by utilizing artificial intelligence. The ability and will of the user were processed by artificial intelligence to determine the model, media, and materials suitable for the user. The results of testing in this virtual laboratory obtained accuracy values according to users based on personalized obtained at 90.8%.