Abstract-Innovation has traditionally been the focus of China and has the most potential for development. Similarly, master's graduate training must also consider the issue of innovation. However, the reform of our country's education and training model for graduate students has yet to be deepened. In our research, we combine the actual situation of undergraduate teaching, scientific research and graduate education in school of pharmacy, Jiangxi Science & Technology Normal University. First of all, the graduate student of our research group was chosen as the research object of cultivating innovative ability. Subsequently, research and discussion on the training mode of innovative ability of pharmacy graduate students were started. In this research, the majority of graduate students, under the mode of co-mentor training, have significantly improved their academic performance during their study at school. The number of outstanding reports, in the opening report, mid-term evaluation and graduation reply, increased significantly, the number of published papers indexed by SCI increased by 50%.