1987
DOI: 10.1016/s0735-1097(87)80273-5
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Preload dependence of doppler-derived indexes of left ventricular diastolic function in humans

Abstract: To determine the effect of filling pressure on the pattern of left ventricular filling in humans, the mitral flow velocity profile was measured by pulsed wave Doppler echocardiography during right and left heart catheterization in 11 patients before and during nitroglycerin infusion. Nitroglycerin reduced mean arterial pressure from 90 +/- 9 to 80 +/- 11 mm Hg (p less than 0.001) and mean pulmonary capillary wedge pressure from 9 +/- 4 to 4 +/- 2 mm Hg (p less than 0.001). Cardiac output fell from 6.6 +/- 1.5 … Show more

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Cited by 628 publications
(235 citation statements)
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“…18,19 However, an alteration in LV chamber stiffness was not excluded, and the effects of increasing preload on the velocity and distribution of transmitral blood flow during diastole were not studied in either study.…”
Section: Influence Of Alteration In Preloadmentioning
confidence: 99%
“…18,19 However, an alteration in LV chamber stiffness was not excluded, and the effects of increasing preload on the velocity and distribution of transmitral blood flow during diastole were not studied in either study.…”
Section: Influence Of Alteration In Preloadmentioning
confidence: 99%
“…These parameters are known to be preload dependent (12,13). This is a confounding factor in HD patients, in whom filling pressure changes independent of cardiac function, as the volume status is acutely altered by UF.…”
mentioning
confidence: 99%
“…The loading condition of the right ventricle changes markedly during the transition from fetal to neonatal circulation, and continues to be unstable shortly after birth. Among the hemodynamic factors affecting left and right ventricular diastolic filling, preload appears to play an important role, as documented by recent studies (Choong et al 1987; Courtois et al 1988; Triulzi et al 1990; Odake et al 1991;Castini et al 1992). We have demonstrated the effects of a patent ductus arteriosus on left ventricular diastolic filling (Harada et al 1994) However, the impact of changes in preload on the transtricuspid flow pattern in this period is less clear.…”
mentioning
confidence: 54%