Premalignant nature of oral lichen planus. A retrospective study of 550 oral lichen planus patients from south-eastern Spain

Bermejo‐Fenoll, Ambrosio; Sánchez‐Siles, Mariano; López‐Jornet, Pía; Camacho-Alonso, Fabio; Salazar-Sánchez, Noemí

doi:10.1016/j.oraloncology.2009.01.009

Cited by 57 publications

(54 citation statements)

References 19 publications

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“…[23] In this context, Genetic factors influencing immune function may contribute to OLP pathogenesis. many studies have focused on the relationship between HLA and OLP, demonstrating that an association has been observed with HLA-A3, A11, A26, A28, B3, B5, B7, B8, DR1, and DRW9.…”

Section: Genetic Backgroundmentioning

confidence: 99%

Clinical and Genetic Aspects of Oral Lichen Planus

Haqiqi

Pourmoshir

Bereshneh

2016

Int J of Biomed & Adv Res

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Lichen planus (LP) is a chronic inflammatory muco-cutaneous disease. Oral Lichen Planus (OLP) is often asymptomatic; the atrophic-erosive form can cause symptoms ranging from burning sensation to severe pain, interfering with speaking, eating, and swallowing. OLP can be a source of severe morbidity and has a small potential to be malignant. The prevalence of OLP varies from 0.5% to 4% of the general population and in spite of extensive research; exact etiology of OLP remains unclear. A proper understanding of the clinical presentation, pathogenesis and diagnosis of the disease becomes important for providing the right treatment. The present review draws together aspects of Epidemiology, Clinical Features, Etiopathogenesis with emphasis on Genes involved in OLP pathogenesis and the clinical management of OLP.

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Section: Genetic Backgroundmentioning

confidence: 99%

Clinical and Genetic Aspects of Oral Lichen Planus

Haqiqi

Pourmoshir

Bereshneh

2016

Int J of Biomed & Adv Res

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“…5 Familial presentation is extremely rare. 6 Oral lichen planus occurs mainly in non-smokers. 7 Little is known about possible geographic differences.…”

Section: Epidemiologymentioning

confidence: 99%

“…21 If this event occurs, it usually concerns the tongue. 6 The suggestion has been made that a certain cell surface marker on hematopoietic stem cells and early progenitor cells in the bone marrow, referred to as CD133, correlates with the progression to oral squamous cell carcinoma. 22 Others have not found any evidence for a potentially malignant behavior.…”

Section: Histopathologymentioning

confidence: 99%

Oral Lichen Planus: Diagnosis and Management

Waal

2015

J Dent Indones

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Oral lichen planus (OLP) is a rather common oral disease, mainly affecting adults, occurring more often in women than in men. The etiopathogenesis is still unclear. The diagnosis may be cumbersome, even in the presence of a biopsy. In addition, there are several lesions that may resemble lichen planus (lichenoid lesions) both clinically and histopathologically. Treatment of OLP can only be symptomatic and usually consists of topical application of corticosteroids. The disease is characterized by remissions and exacerbations and may persist in some patients lifelong. There is an ongoing debate in the literature as whether OLP is a potentially malignant disease. Because of this uncertainty, annual follow-up is advised.

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“…Numerous reports have been published assessing the malignant potential of OLP. In general a 0.5-2% chance of OLP turning into oral squamous cell carcinoma has been described [26][27][28][29][30][31].…”

Section: Malignant Transformationmentioning

confidence: 99%

Oral Lichen Planus: A Review of Etiopathogenesis, Clinical, Histological and Treatment Aspects

Chitturi¹

2014

J Interdiscipl Med Dent Sci

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It is a well known fact that oral lichen planus (OLP) is a non infectious disease affecting the oral mucous membrane. It is considered to be an autoimmune disorder mediated mainly by the T-lymphocytes. It affects 1-2% of the general population with maximum prevelance seen among women above the age of 40. WHO considers it to be a potentially malignant disorder and the rate of malignant transformation has been put between 0.5-2%. This article mainly reviews the various pathogenetic mechanisms by which this unique disorder occurs along with the clinical, histopathological and treatment aspects.

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Premalignant nature of oral lichen planus. A retrospective study of 550 oral lichen planus patients from south-eastern Spain

Cited by 57 publications

References 19 publications

Clinical and Genetic Aspects of Oral Lichen Planus

Clinical and Genetic Aspects of Oral Lichen Planus

Oral Lichen Planus: Diagnosis and Management

Oral Lichen Planus: A Review of Etiopathogenesis, Clinical, Histological and Treatment Aspects

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