Premature atherosclerosis in Indian children with Juvenile Idiopathic Arthritis: A cross-sectional study

Guha, Suparna; Haldar, Arunansu; Choubey, Amit Kumar; Pal, Samar

doi:10.4038/sljch.v50i1.9399

Cited by 1 publication

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“…Table 6 highlights the comparison between major findings on this aspect in previous publications and our study in a nutshell. [11][12][13][14][15][16] Our research work is one of the few in literature which assessed the clinical symptoms and the effect of alterations in complete blood counts, acute phase reactants and first line drugs on lipid profile in JIA patients.…”

Section: Discussionmentioning

confidence: 99%

Changes in biomarkers of lipid in juvenile idiopathic arthritis and its association with various disease parameters: a 6-month follow-up study

Mitra,

Nandi,

Mahato

et al. 2024

Int J Contemp Pediatr

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Background: The objectives of our study were to determine the changes in lipid profile (total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C)) in juvenile idiopathic arthritis (JIA) and assess its association with epidemiological and clinical profile of JIA patients. Methods: This observational study was performed with 46 patients at presentation followed by 38 cases at 3 months and 18 cases at 6 months of follow up. Their demographic profile and clinical parameters including juvenile disease activity score (JADAS 27) were compared with the biomarkers of lipid profile. Results: The mean (SD) age was 105.85 (20.23) months at first visit with mean (SD) disease duration being 15 (6.4) months. Twenty-six participants had oligoarthritic (56.5%), while the rest had polyarthritis (43.4%). Most of the patients had borderline raised TG and LDL-C (cases with raised TG n=14 (30.4%), 12 (31.5%), 5 (27.7%) at 1st visit, 3 months, and 6 months respectively and LDL-C n=12 (26%), 10 (26.3%), 6 (33.3%) at 1stvisit, 3 months, and 6 months respectively). HDL-C level was low in 36 (78.2%) cases at first visit, 28 cases (73.6%) at 3 months and 12 cases (66.6%) at 6 months respectively. Lipid profile was significantly affected by gender difference, duration of disease and drug therapy (p<0.05). Significant association have been found between JADAS score and TGL level with p value 0.03. Conclusions: Children with JIA definitely suffer from dyslipidemia. Among the biomarkers of lipid profile, low level of HDL-C is one of the most important highlights of our study. Further studies can help to strengthen the findings and formulate necessary interventions at an early stage.

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