Premature ejaculation

Abstract

Premature ejaculation (PE) is a common male sexual disorder. Recent normative data suggests that men with an intravaginal ejaculatory latency time (IELT) of less than 1 minute have “definite” PE, while men with IELTs between 1 and 1.5 minutes have “probable” PE. Although there is insufficient empirical evidence to identify the etiology of PE, there is limited correlational evidence to suggest that men with PE have high levels of sexual anxiety and inherited altered sensitivity of central 5-HT (5-hydroxytryptamine, serotonin) receptors. Pharmacological modulation of the ejaculatory threshold using off-label daily or on-demand selective serotonin re-uptake inhibitors is well tolerated and offers patients a high likelihood of achieving improved ejaculatory control within a few days of initiating treatment, consequential improvements in sexual desire and other sexual domains. Investigational drugs such as the ejaculo-selective serotonin transport inhibitor, dapoxetine represent a major development in sexual medicine. These drugs offer patients the convenience of on-demand dosing, significant improvements in IELT, ejaculatory control and sexual satisfaction with minimal adverse effects.

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“…However, many questions about how drugs, especially herbal drugs, affect premature ejaculation remain unanswered. Meanwhile, studies indicated that the relief of mental problems and the prevention of serotonin reuptake such as the SSRIs with sedative properties can help to treat this disorder 39,[47][48][49][50] . Overall, medicinal plants are effective on sexual dysfunction via several mechanisms of action (Fig.…”

Assessing satisfaction in men with premature ejaculation after dapoxetine treatment in real-world practice

“…PE is associated with some psychosocial factors such as immature sexual technique, and low frequency of sexual activity (36). In dapoxetine clinical trials, a substantial proportion of patients in placebo group reported an improvement in IELT, which indicates that increased sexual frequency may have effect on ameliorating PE symptoms (12).…”

A Cross-sectional study to explore Sexual dysfunctions among male Hypertensive Patients attending Medicine OPD of Tertiary care centre, Western India

“…The prevalence of ED is significantly higher among men with hypertension than in general population [5][6][7][8][9]. A decrease risk of premature ejaculation (PE) has been reported in men with treated diabetes, while no association was found with hypertension, cardiac disease, hypercholesterolemia and peripheral or central neuropathy [10]. Few studies have been done on this topic in India and hence doing such a study in our setup will be helpful in identifying sexual dysfunctions in hypertensive male patients and treating this aspect of the disease as well.…”