Premature Greying of the Hair Is Not Associated with Low Bone Mineral Density

Beardsworth, S. A.; Kearney, C. E.; Steel, S. A.; Newman, Jovita J.; Purdie, David W

doi:10.1007/s001980050229

Cited by 9 publications

(10 citation statements)

References 14 publications

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“…Premature greying may be a weak marker for reduced bone mineral density (BMD) in women with a history of Graves' disease, but it is not a marker in normal women [33]. But later studies showed no such link [34].…”

Section: Aetiopathogenesismentioning

confidence: 99%

Premature Greying of Hair (Premature Canities): A Concern for Parent and Child

Nigam¹,

Nigam²

2017

Pigmentary Disorders

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Hair goes grey with chronological aging. Premature hair greying may have significant adverse effects on the appearance, self-esteem, and socio-cultural acceptance of the affected individual. The exact aetiopathogenetic mechanism causing premature greying is still not clear and much speculative. Premature canities may appear alone as an autosomal dominant trait or it may occur in association with certain other disorders. The genes Pax3 and MITE play an important role in melanocyte stem cell maintenance and differentiation. Defective melanosomal transfer to the cortical keratinocytes or melanin incontinence due to melanocyte degeneration is also believed to contribute to greying. Despite the extensive molecular research being carried out to understand the pathogenesis of canities, treatment options still remain far from satisfactory and no effective therapy is available. Premature greying is a feature in a number of well recognised syndromes. A number of other conditions have also been observed to be associated with premature greying of hair.

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Section: Aetiopathogenesismentioning

confidence: 99%

Premature Greying of Hair (Premature Canities): A Concern for Parent and Child

Nigam¹,

Nigam²

2017

Pigmentary Disorders

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“…[ 4 5 ] However, some studies showed that there is no correlation between the two. [ 6 7 ] We conducted a case–control study to compare the degree of osteopenia in healthy individuals with premature graying of hair (PGH) and those without PGH.…”

Section: Introductionmentioning

confidence: 99%

A study of association of premature graying of hair and osteopenia in North Indian population

et al. 2020

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Context: Hair graying is one of the signs of human aging and is caused by a progressive loss of pigmentation from growing hair shafts. Studies have shown a correlation of early hair graying with osteopenia, indicating that premature graying could serve as an early marker of osteopenia. Aim: To compare the degree of osteopenia in individuals with premature graying of hair (PGH) compared to ordinary individuals. Settings and Design: We conducted an observational, case–control study among 132 healthy individuals between 18 and 30 years of age. Subjects and Methods: Detailed history and examination of PGH was taken. Bone mineral density (BMD) was assessed using Furuno CM-200 ultrasound bone densitometer. Statistical Analysis: SPSS 21 software was used, and the data were summarized in the form of mean ± standard deviation for quantitative values and percentages for qualitative values. Chi–square test, Student's t -test, analysis of variance, and other appropriate tests were applied for comparison, and P < 0.05 was considered statistically significant. Results: PGH was present in 82 (62.1%) cases, whereas osteopenia was present in 56 (42.4%) cases. The mean age of onset of graying of hair among the cases was 20.62 ± 3.74 years. A higher age group of 25–30 years ( P = 0.016) and family history of PGH ( P < 0.001) were significant risk factors for PGH. The mean BMD of the case group was 0.76 ± 1.00 and the control group was 0.68 ± 1.11, but the difference was not statistically significant ( P = 0.649). Conclusion: The study concluded that there is no significant association between osteopenia and PGH.

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“…On the other hand, well-known conditions in menopausal women are decrease in Bone Mineral Density (BMD) and Hair-Loss (HL) because the loss of physiological levels of estrogens and androgens [5]. Some risk factors for osteoporosis such as age, sex, race, family history, early menopause, oophorectomy, prolonged amenorrhea, lack of physical exercise and bone depleting medical conditions have been accepted, but it has been considered that these factors do not predict all of the observed changes in BMD and the factors should be better defined [6]. In our daily practise, during the detection of etiopathological reasons in AGA patients, we noticed that a significant number of women had joint complaints in their systematical examinations.…”

Section: Introductionmentioning

confidence: 99%

Changes in bone mineral density in women with early-onset androgenetik alopecia and their correlations with hair-loss stages: a cross-sectional study

Taş¹,

Artar²,

Albayrak³

et al. 2018

biomedicalresearch

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Androgenetic alopecia is a common cosmetical condition that accompany by some disorders with high androgen level. Evaluating the possible relationship between androgenetic alopecia and bone mineral density, and its relevance with hair-loss stages were aimed. A cross-sectional study including 106 alopecia patients who also had joint complaints, was conducted on screening of recorded data regarding hair loss stages, bone mineral density and fix and modifiable factors related with bone density, such as body mass index, daily consumptions of calcium, caffeine and alcohol, smoking, birth count, daily sun exposure, usual physical activity, and hormone values including free and total testosterone, dehydroepiandrosterone sulfate, androstenedione, sex hormone binding globulin, follicular stimulating hormone, leutinizing hormone, 25-hydroxy cholecalciferol, ionized calcium, inorganic phosphorus and alkaline phosphatase. Alopecia was classified by hair loss-scale of Ludwig. Bone mineral density in the hip and lumbar spine was measured by dual energy X-ray absorptiometry (Stratos dR 2D Fan-Beam). Data was analysed by Number Cruncher Statistical System, 2007. Results were compared to p<0.05. About 90% of the subjects were under the age of 35 and 60% of them were in the Ludwig stage-2. Osteopenia was detected in the rates of 34.90%, 36.79% and 23.58%, and osteoporosis was detected in the rates of 4.72%, 5.66% and 3.77% in femur-neck, total hip and lumbar spine T-scores, respectively. Z-scores were lower in the rates of 19.81%, 14.15% and 11.32 % in the same order, compare to the agematched reference values. Predisposing factors, laboratory test results and bone mineral density scores did not show any differences according to the Ludwig stages (each at p>0.05). We suggest that all women with early-onset androgenetic alopecia should be thoroughly investigated to the possibility of premature bone loss.

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Premature Greying of the Hair Is Not Associated with Low Bone Mineral Density

Cited by 9 publications

References 14 publications

Premature Greying of Hair (Premature Canities): A Concern for Parent and Child

Premature Greying of Hair (Premature Canities): A Concern for Parent and Child

A study of association of premature graying of hair and osteopenia in North Indian population

Changes in bone mineral density in women with early-onset androgenetik alopecia and their correlations with hair-loss stages: a cross-sectional study

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