Prematurity and "Cerebral Palsy"

Polani, P. E.

doi:10.1136/bmj.2.5111.1497

Cited by 41 publications

(11 citation statements)

References 19 publications

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“…Preterm birth was noted to be associated with a higher risk of CP by the first authors describing the disease[32]. Using part of the same cohort as in our study, Catov et al found that women with a prior preterm birth had excess cardiovascular disease after adjustment for age, parity, and education[33].…”

Section: Discussionsupporting

confidence: 58%

Congenital Cerebral Palsy, Child Sex and Parent Cardiovascular Risk

Streja

Uldall

et al. 2013

PLoS ONE

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ObjectiveGenes associated with cardiovascular disease may also be risk factors for congenital cerebral palsy (CP) and these associations may be modified by sex, since there is an increased risk of CP in male children. We investigated the association between CP of the child with cardiovascular disease in parents, taking sex of the child into consideration.MethodsAll parents of non-adopted singletons born in Denmark between 1973 and 2003 were included. Parents of a child with CP, confirmed by the Danish National CP registry, were considered exposed. Cox proportional hazards regressions were used to model risk of cardiovascular outcomes for exposed parents compared to all other parents beginning at the child’s 10th birthday.ResultsWe identified 733,730 mothers and 666,652 fathers among whom 1,592 and 1,484, respectively, had a child with CP. The mean age for mothers at end of follow up was 50±8 years. After adjustment for maternal age, parental education, child’s sex, child’s residence, child being small for gestational age and maternal hypertensive disorder during pregnancy, mothers of CP male children had an excess risk of cardiovascular disease (HR: 1.52, 95% CI: 1.16-2.00), attributable mostly to an increased incidence of hypertension and cerebrovascular disease. After additional adjustment for preterm birth, the association was markedly attenuated for cardiovascular disease (1.34, 95%CI: 1.02 - 1.76), became nonsignificant for hypertension, but remained significant for cerebrovascular disease (HR: 2.73, 95% CI: 1.45- 5.12). There was no increased risk of cardiovascular events in mothers of female CP children, or fathers of CP children of any sex.ConclusionsWomen that have a male child with CP are at increased risk for premature cardiovascular disease. Part of this association may be related to risk factors for preterm births.

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Section: Discussionsupporting

confidence: 58%

Congenital Cerebral Palsy, Child Sex and Parent Cardiovascular Risk

Streja

Uldall

et al. 2013

PLoS ONE

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“…The lesions may therefore lie in the distal endings of the cortico-spinal axons, in the caudal part of the spinal cord. Evidence to support this hypothesis has been presented previously [6,8]. It is also interesting that Kinnier-Wilson [7] remarked 'I have often noticed integrity of the abdominals-a curious point'.…”

mentioning

confidence: 77%

Can periventricular leucomalacia cause spastic diplegia in premature infants?

Crawford

2004

Eur J Pediatr

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“…However, while birth injury and asphyxia during delivery were important in causing other types of cerebral palsy, these events were not considered the most likely cause of the typical cerebral palsy of premature infants (McDonald, 1963;Churchill, 1963). Instead, damage occurring after birth was considered a more likely cause, possibly by interfering with the development of certain neurones which were maturing at this critical time (Polani, 1958(Polani, , 1959.…”

Section: The Era Of Delayed Feedingmentioning

confidence: 99%

The first feed of low birthweight infants. Changing attitudes in the twentieth century.

Davies¹

1978

Archives of Disease in Childhood

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Prematurity and "Cerebral Palsy"

Cited by 41 publications

References 19 publications

Congenital Cerebral Palsy, Child Sex and Parent Cardiovascular Risk

Congenital Cerebral Palsy, Child Sex and Parent Cardiovascular Risk

Can periventricular leucomalacia cause spastic diplegia in premature infants?

The first feed of low birthweight infants. Changing attitudes in the twentieth century.

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