Premedication Before Day Surgery

Jakobsen, Henrik; Hertz, J. B.; Johansen, Jytte R.; Hansen, Aksel; Kølliker, K

doi:10.1093/bja/57.3.300

Cited by 31 publications

(3 citation statements)

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“…Other benzodiazepines available in oral preparations have been used for the premedication of adult outpatients. Preoperative discomfort and apprehension have been shown to be significantly reduced by diazepam (0.25 mg/kg, Valium®) [ 21 22 ]. However, we did not select oral diazepam as an active comparator in this study, as its anxiolytic index score for 10 mg is half that of alprazolam 0.5 mg [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Use of triazolam and alprazolam as premedication for general anesthesia

Kim

Lee

Pyeon

et al. 2015

Korean J Anesthesiol

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BackgroundTriazolam has similar pharmacological properties as other benzodiazepines and is generally used as a sedative to treat insomnia. Alprazolam represents a possible alternative to midazolam for the premedication of surgical patients. The purpose of this study was to evaluate the anxiolytic, sedative, and amnestic properties of triazolam and alprazolam as pre-anesthetic medications.MethodsSixty adult patients were randomly allocated to receive oral triazolam 0.25 mg or alprazolam 0.5 mg one hour prior to surgery. A structured assessment interview was performed in the operating room (OR), the recovery room, and the ward. The levels of anxiety and sedation were assessed on a 7-point scale (0 = relaxation to 6 = very severe anxiety) and a 5-point scale (0 = alert to 4 = lack of responsiveness), respectively. The psychomotor performance was estimated using a digit symbol substitution test. As a memory test, we asked the patients the day after the surgery if they remembered being moved from the ward to the OR, and what object we had shown them in the OR.ResultsThere were no significant differences between the groups with respect to anxiety and sedation. The postoperative interviews showed that 22.2% of the triazolam-treated patients experienced a loss of memory in the OR, against a 0% memory loss in the alprazolam-treated patients. In comparison with alprazolam 0.5 mg, triazolam 0.25 mg produced a higher incidence of amnesia without causing respiratory depression.ConclusionsOral triazolam 0.25 mg can be an effective preanesthetic medication for psychomotor performance.

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Section: Discussionmentioning

confidence: 99%

Use of triazolam and alprazolam as premedication for general anesthesia

Kim

Lee

Pyeon

et al. 2015

Korean J Anesthesiol

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“…2 Benzodiazepines such as diazepam have been satisfactorily used for outpatients i. 3 although the long elimination half-life of this compound and its active metabolites may result in a small but prolonged impairment of psychomotor performance.…”

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confidence: 99%

Placebo Controlled Comparison of Midazolam, Triazolam and Diazepam as Oral Premedicants for Outpatient Anaesthesia

Forrest

Galletly

Yee

1987

Anaesth Intensive Care

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Two short-acting benzodiazepines, midazolam 15 mg and triazolam 0.25 mg, were compared with diazepam 10 mg and placebo as oral premedicants in 120 patients presenting for minor urological surgery. Midazolam was found to produce the greatest degree of amnesia and sedation at the time of anaesthetic induction and triazolam was found to have the greatest degree of residual sedation at the time of discharge, four hours postoperatively. These effects are consistent with the greater potency and more rapid onset of action of midazolam at this dose compared with triazolam. The relative merits of the compounds as anxiolytics varied depending upon the observer, time and method of assessment. It was considered that the doses of midazolam and triazolam used were excessive for routine day case anaesthesia.

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“…Diazepam (5 -10 mg p.o. ), given 1 -2 h preoperatively, is a very effective medication, which usually does not prolong recovery time [259]. Parenteral diazepam (5 -10 mg i.v.…”

Section: Preoperative Preparationmentioning

confidence: 99%

Anesthesia for Liposuction and Abdominoplasty

Bennett¹

Aesthetic Surgery of the Abdominal Wall

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Premedication Before Day Surgery

Cited by 31 publications

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Use of triazolam and alprazolam as premedication for general anesthesia

Use of triazolam and alprazolam as premedication for general anesthesia

Placebo Controlled Comparison of Midazolam, Triazolam and Diazepam as Oral Premedicants for Outpatient Anaesthesia

Anesthesia for Liposuction and Abdominoplasty

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