Premenopausal women deposit more collagen than men during healing of an experimental wound

Jørgensen, Lars N.; Sørensen, Lars Tue; Kallehave, Finn; Vange, Jakob; Gottrup, Finn

doi:10.1067/msy.2002.119986

Cited by 43 publications

(33 citation statements)

References 31 publications

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“…It has also been demonstrated in experimental wounds that female reproductive hormones appear to play a major role in the healing process 83 , and that women accumulate more collagen than aged-matched men 84,85 . Smokers have a higher risk of developing both incisional and recurrent inguinal hernias, probably as a result of reduced collagen synthesis and increased collagen breakdown 86 .…”

Section: Discussionmentioning

confidence: 98%

Connective tissue alteration in abdominal wall hernia

Henriksen

Yadete

Sørensen

et al. 2011

Journal of British Surgery

131

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Section: Discussionmentioning

confidence: 98%

Connective tissue alteration in abdominal wall hernia

Henriksen

Yadete

Sørensen

et al. 2011

Journal of British Surgery

131

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“…The finding that female patients revealed an increased collagen-protein ratio compared to male patients is concordant with several studies published. Jorgensen et al found an increased collagen deposition and collagen-protein ratio in pre-menopausal women after subcutaneous implantation of expanded polytetrafluoroethylene test tubes [23]. Lenhardt et al reported that collagen deposition after surgery decreased significantly with age in men, in contrast to women undergoing comparable operations [24].…”

Section: Discussionmentioning

confidence: 97%

Decreased collagen type�I/III ratio in patients with recurring hernia after implantation of alloplastic prostheses

Junge

Klinge

Rösch

et al. 2004

Langenbeck's Archives of Surgery

157

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“…Much of the current literature [14][15][16] on wound healing stems from dermal wounds, and a clear sex difference in favor of women is evident. However, the current study indicates that men heal oral mucosal wounds more quickly than women.…”

Section: Commentmentioning

confidence: 99%

“…Sex has been implicated as a factor in wound healing, and a number of studies [14][15][16] clearly show a female advantage in human healing rates. However, these findings are mainly derived from dermal wound studies, and a female advantage in the healing of nondermal wounds is unapparent.…”

mentioning

confidence: 99%

Mucosal Wound Healing

et al. 2006

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It remains unclear whether aging delays wound healing, as past human studies have not adequately controlled for confounding factors such as morbidity and medications. Furthermore, although dermal wounds heal more quickly in women than in men, clinical observations suggest that the opposite may be true for mucosal healing. We assessed age and sex differences in mucosal wound healing, and we hypothesized that aging delays healing and sex modulates healing independent of age. Design and Setting: Clinical experimental study performed from June 2000 to August 2003 involving younger and older adult volunteers from the general community. Participants: Two hundred twelve male and female volunteers aged 18 to 35 years (n = 119) or 50 to 88 years (n=93).Intervention: Standardized 3.5-mm circular wounds were placed on the oral hard palates of volunteers.Main Outcome Measure: Wound videographs were taken daily for 7 days after wounding to assess wound closure.Results: Wounds healed significantly more slowly in older adults compared with younger adults (PϽ.001) regardless of sex. This remained true even when individuals receiving medication and/or having a coexisting medical condition were excluded. Mucosal wounds healed more slowly in women than in men (P =.008) regardless of age. These effects were independent of demographic factors such as ethnicity, alcohol or nicotine use, or body mass index.Conclusions: Wound closure in older individuals was clearly delayed even when eliminating potential agerelated confounds, indicating that aging does slow wound healing. Wound closure in women was also delayed, suggesting that wound healing is modulated by different mechanisms depending on tissue type. These findings may help target patients with increased surgical risks and greater need for postsurgical care.

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Premenopausal women deposit more collagen than men during healing of an experimental wound

Cited by 43 publications

References 31 publications

Connective tissue alteration in abdominal wall hernia

Connective tissue alteration in abdominal wall hernia

Decreased collagen type�I/III ratio in patients with recurring hernia after implantation of alloplastic prostheses

Mucosal Wound Healing

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