Prenatal and Early Postnatal Exposure to Persistent Organic Pollutants (POPs): What Is the Correlation between Dioxins and Long-Chain Per- and Polyfluorinated Alkyl Substances (PFAS)?

Abraham, Klaus

doi:10.1289/ehp13313

Cited by 2 publications

(1 citation statement)

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“…On PND 7, the mean HBCD concentration was 66 ng/g (lipid) in HBCD-treated mouse livers, while the concentrations of TBBPA-DBMPE were 109 and 882 ng/g (lipid) in the TD-50 and TD-1000 groups, respectively (Figure ). The data show that TBBPA-DBMPE can transfer from dams to pups through breast milk, like HBCD and other POPs. − Compared with the data on PND 7, their burdens in livers on PND 56 remarkably increased, with 246 ng/g HBCD in the HB-50 group and 201 and 1981 ng/g TBBPA-DBMPE in the TD-50 and TD-1000 groups, respectively. These observations demonstrate the bioaccumulation of TBBPA-DBMPE with time.…”

Section: Resultsmentioning

confidence: 89%

Bioaccumulation and Male Reproductive Toxicity of the New Brominated Flame Retardant Tetrabromobisphenol A-Bis(2,3-dibromo-2-methylpropyl ether) in Comparison with Hexabromocyclododecane

Li,

Shi,

Xiong

et al. 2024

Environ. Sci. Technol.

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Tetrabromobisphenol A-bis(2,3-dibromo-2-methylpropyl ether) (TBBPA-DBMPE) has come into use as an alternative to hexabromocyclododecane (HBCD), but it is unclear whether TBBPA-DBMPE has less hazard than HBCD. Here, we compared the bioaccumulation and male reproductive toxicity between TBBPA-DBMPE and HBCD in mice following long-term oral exposure after birth. We found that the concentrations of TBBPA-DBMPE in livers significantly increased with time, exhibiting a bioaccumulation potency not substantially different from HBCD. Lactational exposure to 1000 μg/kg/d TBBPA-DBMPE as well as 50 μg/kg/d HBCD inhibited testis development in suckling pups, and extended exposure up to adulthood resulted in significant molecular and cellular alterations in testes, with slighter effects of 50 μg/kg/d TBBPA-DBMPE. When exposure was extended to 8 month age, severe reproductive impairments including reduced sperm count, increased abnormal sperm, and subfertility occurred in all treated animals, although 50 μg/kg/d TBBPA-DBMPE exerted lower effects than 50 μg/kg/d HBCD. Altogether, all data led us to conclude that TBBPA-DBMPE exerted weaker male reproductive toxicity than HBCD at the same doses but exhibited bioaccumulation potential roughly equivalent to HBCD. Our study fills the data gap regarding the bioaccumulation and toxicity of TBBPA-DBMPE and raises concerns about its use as an alternative to HBCD.

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Section: Resultsmentioning

confidence: 89%