Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts

Papadopoulou, Eleni; Stratakis, Nikos; Basagaña, Xavier; Brantsæter, Anne Lise; Casas, Maribel; Fossati, Serena; Gražulevičienė, Regina; Haug, Line Småstuen; Heude, Barbara; Maitre, Léa; McEachan, Rosemary; Robinson, Oliver; Roumeliotaki, Theano; Sabidó, Eduard; Borràs, Eva; Urquiza, José; Vafeiadi, Marina; Zhao, Yinjian; Slama, Rémy; Wright, John; Conti, David V.; Vrijheid, Martine; Chatzi, Lida

doi:10.1016/j.envint.2021.106853

Cited by 52 publications

(32 citation statements)

References 83 publications

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“…A significantly inverse association with PFOA was also found for IL-10 (β = − 0.22) among 101 healthy 1-year-old children 25 . Additionally, prenatal PFOS and PFNA in children aged 8 years were inversely related to Th2 cytokines (IL-4 and IL-13) in children from 1,101 mothers-child pairs in the Human Early Life Exposome project (HELIX) 26 . These evidences seem to suggest that PFAS may induce the production of pro-inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

Emerging and legacy PFAS and cytokine homeostasis in women of childbearing age

Nian

Zhou

Feng

et al. 2022

Sci Rep

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Per- and polyfluoroalkyl substances (PFAS) are widespread chemicals. Legacy PFAS have been phased out of production in most developed countries and emerging PFAS (short-chain PFAS and polyfluorinated compounds) are used as legacy PFAS alternatives. The effect of legacy and emerging PFAS on cytokine homeostasis in human remains poorly understood. This study aimed to evaluate the associations between legacy and emerging PFAS and cytokine profiles, and identify the main contributors to the disturbance of cytokine homeostasis. We quantified 21 PFAS in 198 Chinese women of childbearing age from 2015 to 2016. 13 cytokines were measured using the Meso Scale Discovery U-PLEX and V-PLEX platforms. The associations between PFAS exposure and cytokine levels were assessed using multiple linear regression (single-exposure), and Bayesian kernel machine regression (BKMR) models (PFAS mixture exposure). In single PFAS models, legacy and alternative PFAS were positively associated with Th1 and Treg cytokines, and negatively associated with Th2 and Th17 cytokines. For instance, each ln-unit increase in 6:2 chlorinated perfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA), perfluorooctanoic acid (PFOA), and perfluorooctane sulfonate (PFOS) was associated with a decrease in IL-10 by − 0.228 (95% CI: − 0.336, − 0.120), − 0.153 (95% CI: − 0.277, − 0.030), and − 0.174 (95% CI: − 0.339, − 0.010), respectively. The BKMR model showed a significantly positive association of PFAS mixture with TGF-β and a negative association with IL-10. Overall, these results indicate that both legacy and emerging PFAS may affect the homeostasis of cytokines.

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Section: Discussionmentioning

confidence: 99%

Emerging and legacy PFAS and cytokine homeostasis in women of childbearing age

Nian

Zhou

Feng

et al. 2022

Sci Rep

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“…Subsequently, the change in BMI z-scores was defined as infant growth. Second, the BMI trajectory was characterized as childhood growth based on repeated measurements of BMI from birth up to 8 years, prior to possible growth acceleration due to early puberty (Papadopoulou et al, 2021).…”

Section: Outcome Assessmentmentioning

confidence: 99%

Prenatal exposure to persistent organic pollutants and changes in infant growth and childhood growth trajectories

et al. 2023

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“…Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention (Vrijheid Martine;Basagaña 2021). This makes early life a relevant starting point for exposome studies.…”

Section: Eu Funded Project Athletementioning

confidence: 99%

“…Six prospective birth cohort studies were contributing to HELIX as the only realistic and feasible way to obtain the comprehensive, longitudinal, human data needed to build this early-life exposome. These cohorts have already collected large amounts of data as part of national and EU-funded projects (Haug, Sakhi et al 2018, Tamayo-Uria, Maitre et al 2019, Papadopoulou, Stratakis et al 2021. Results are integrated with data from European cohorts (>300,000 subjects) and registers, to estimate health impacts at the large European scale.…”

Section: Eu Funded Project Athletementioning

confidence: 99%

Roadmap for action on Risk Assessment of Combined Exposure to Multiple Chemicals (RACEMiC)

Jong

Voet

Marx‐Stoelting

et al. 2022

EFS3

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EFSA's aim by 2030, is that the Agency and its partners will be equipped for the routine implementation of human health risk assessment to multiple chemicals, across EFSA's domains of activity. To facilitate this effort, a roadmap for action has been developed by mapping the methods, data and tools that are currently available for mixture risk assessment and identifying current scientific gaps including challenges and blockers. The results shows that extensive methods, data and tools are available for dietary mixture risk assessment for pesticides, but that several scientific gaps still exist for the non‐dietary mixture exposure to pesticides. For food additives and for certain contaminants, the regulatory readiness for mixture risk assessment was also found to be fairly high compared to food contact materials and cross‐silo mixture risk assessment. The scientific gaps identified were prioritised according to their impact on the implementation of mixture risk assessment and, as a result, ten multi‐annual project proposals were defined to address these scientific gaps on the short‐term, mid‐term and long‐term. The roadmap also proposes and prioritises a number of working areas in the regulatory domains of pesticides, food contact materials, contaminants, food additives, as well as in the overarching domain of chemicals. Besides the scientific proposals, recommendations to improve stakeholder engagement and communication on mixture risk assessment was investigated. These included, among others, creating an online catalogue of tools, methods and data for mixture risk assessment, as well as the organisation of regular webinars/workshop to promote exchange of information between stakeholders and making more efficient use of national communication hubs for food safety in communicating with the general public.

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Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts

Cited by 52 publications

References 83 publications

Emerging and legacy PFAS and cytokine homeostasis in women of childbearing age

Emerging and legacy PFAS and cytokine homeostasis in women of childbearing age

Prenatal exposure to persistent organic pollutants and changes in infant growth and childhood growth trajectories

Roadmap for action on Risk Assessment of Combined Exposure to Multiple Chemicals (RACEMiC)

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