Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis

Roduit, Caroline; Wohlgensinger, Johanna; Frei, Remo; Bitter, S.; Bieli, Christian; Loeliger, Susanne; Büchele, Gisela; Riedler, Josef; Dalphin, Jean‐Charles; Remes, Sami; Roponen, Marjut; Pekkanen, Juha; Kabesch, Michael; Schaub, Bianca; Mutius, Erika von; Braun‐Fahrländer, Charlotte; Lauener, Roger

doi:10.1016/j.jaci.2010.10.010

Cited by 153 publications

(140 citation statements)

References 35 publications

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“…Consistently with this notion, changes in cord blood innate immune gene expression patterns have been observed in neonates whose mothers live in a farming environment and are thus presumably exposed to a wide variety of microbes (63). Such a prenatal environment has previously been reported to protect the offspring from the development of atopic disease (64).…”

Section: Immune Programming and Early Microbial Contactmentioning

confidence: 54%

Gut microbiota: a source of novel tools to reduce the risk of human disease?

et al. 2014

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Section: Immune Programming and Early Microbial Contactmentioning

confidence: 54%

Gut microbiota: a source of novel tools to reduce the risk of human disease?

et al. 2014

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“…The main receptors for bacterial products are the TLRs. Farm studies have also shown that these receptors can be upregulated in neonates after maternal contact with farm animals and after farm-related exposures [14,25,26]. One study investigated both atopic sensitization and the gene expression of receptors of innate immunity (TLRs), and how they were related to maternal exposure to stables during pregnancy.…”

Section: Animal Models Show the Benefit Of Microbial Exposure During mentioning

confidence: 99%

Lactobacillus reuteri, Infant Allergy Prevention and Childhood Immune Maturation

Forsberg¹

2016

Probiotics and Prebiotics in Human Nutrition and Health

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The increasing allergy prevalence in affluent countries may be caused by reduced microbial stimulation, resulting in an abnormal postnatal immune maturation. This chapter concerns the theories behind the use of probiotics in randomized prevention trials, and how this supplementation affects the immunity of pregnant women, the immune development in their children, and possibly preventing allergic diseases. Most studies investigating the underlying mechanisms have focused on postnatal microbial exposure. An increasing body of evidence from studies suggests that the maternal microbial environment during pregnancy can program the immune development of the child. In human allergy intervention studies, probiotic supplementation to the mother during pregnancy, as well as to her baby postnatally, may be important for preventive effects. Also, prenatal environmental exposures may alter gene expression via epigenetic mechanisms, aiming to induce physiological adaptations to the anticipated postnatal environment. The maternal microbial environment during pregnancy may program the immune development of the child.

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“…Data from two large European studies showed that specified environmental exposures could be protective against development of asthma and atopy (31,32 (33). Increased environmental exposure to microbial products has been shown to be protective factor against allergy (34,35). This microbial exposure occurs in early childhood and is determined by mode of birth delivery, farm habitation, or antibiotic use, all of which have been shown to be factors conferring protection or conversely increasing risk of asthma later in life (33,(36)(37)(38)(39)(40).…”

Section: What Are the Mucosal Inflammatory Implications Of The Lung Mmentioning

confidence: 99%