Prenatal cardiac biometry and flow assessment in fetuses with bicuspid aortic valve at 20 weeks' gestation: multicenter cohort study

Abstract

What are the novel findings of this work?This is the first study to investigate prenatal cardiac biometric and flow parameters in a large cohort of fetuses born with a bicuspid aortic valve (BAV). At 20 weeks' gestation, fetuses with BAV had a larger diameter of the aorta at the level of the aortic valve and a larger diameter of the pulmonary artery at the level of the pulmonary valve compared with controls with normal cardiac anatomy. However, the differences were not significant after correcting for multiple comparisons. What are the clinical implications of this work?Our findings do not indicate that cardiac biometric and flow parameters evaluated in the second trimester would be useful in prenatal screening for BAV. However, our findings may help to gain a better understanding of bicuspid aortopathy.