Prenatal cocaine exposure attenuates cocaine-induced odor preference in infant rats

Heyser, Charles J.; Goodwin, Gregory A.; Moody, Carole A.; Spear, Linda P.

doi:10.1016/0091-3057(92)90461-n

Cited by 47 publications

(16 citation statements)

References 31 publications

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“…As mentioned above, there are studies available (Heyser et al, 1992;Rocha et al, 2002;Estelles et al, 2006) showing increased drug-seeking behavior of cocaine or morphine in animals prenatally exposed to cocaine, which is in disagreement to our results. On the other hand, prenatal morphine exposure was shown not to affect self-administration of morphine or cocaine in adulthood (Riley and Vathy, 2006;Vathy et al, 2007).…”

Section: )contrasting

confidence: 57%

“…In contrast to our findings, studies of drug abuse in prenatally cocaine-exposed adult rats (Heyser et al, 1992;Rocha et al, 2002;Estelles et al, 2006) showed increased predisposition to drug abuse in self-administration and CPP tests. These inconsistencies of findings with our model of prenatal MA exposure suggest that cocaine is more potent drug for causing long-term addiction than MA.…”

Section: )contrasting

confidence: 56%

“…For example they responded to lower doses of drug than control animals. Increased predisposition of drug abuse in adulthood has been shown in prenatally cocaine-exposed (Heyser et al, 1992;Rocha et al, 2002;Estelles et al, 2006), cannabinoid-exposed (Vela et al, 1998) and morphineexposed offspring (Gagin et al, 1997) relatively to controls. They showed increased drug-seeking behavior in both "self-administration test" and "conditioned place preference test" (CPP).…”

Section: Introductionmentioning

confidence: 99%

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Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats?

et al. 2012

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R e c e i ve d J a n u a r y 2 3 , 2 0 12 ; A c c e p t e d Ju n e 2 5 , 2 0 1 2 .Key words: Prenatal drug exposure -Methamphetamine -Cocaine -MorphineOpen field -Plantar test -Conditioned place preference -LocomotionNociception -Drug-seeking behavior Abstract:The aim of the present study was to examine the cross-sensitization induced by prenatal methamphetamine (MA) exposure to challenge dose of cocaine or morphine. Rat mothers received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male offspring (prenatally MA-or saline-exposed) were divided to groups with challenge doses of saline (1 ml/kg), cocaine (5 mg/kg) or morphine (5 mg/kg). Behavior in unknown environment was examined in Laboras, nociception in Plantar test, and active drug-seeking behavior in conditioned place preference (CPP). Our data demonstrate that cocaine increased the exploratory activity in Laboras test in prenatally saline-exposed, but decreased it in prenatally MA-exposed rats. An analgesic effect of cocaine was demonstrated only by the tail withdrawal and it was independent of the prenatal drug exposure. CPP test showed that prenatal MA exposure induced rather tolerance than sensitization to cocaine. In contrast to cocaine effects, morphine decreased rearing activity in both, prenatally MA-exposed and saline-exposed rats, and locomotion only in prenatally MA-exposed rats in the Laboras. In the Plantar Prague Medical Report / Vol. 113 (2012) No. 3, p. 189-205 test, the results demonstrated that morphine had an analgesic effect in prenatally saline-exposed rats but this effect was suppressed in prenatally MA-exposed rats. In the CPP test morphine induced drug-seeking behavior, which however was not affected by prenatal drug exposure. Thus, our data demonstrate that there is a cross-effect between prenatal MA exposure and the challenge dose of other drug in adulthood, however drug-seeking behavior is not increased by prenatal MA exposure as we expected.

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Section: )contrasting

confidence: 57%

Section: )contrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

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Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats?

et al. 2012

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“…For example they respond to lower doses of drug than control animals. Increased predisposition of drug abuse in adulthood has been shown in prenatally cocaine-exposed (Heyser et al, 1992;Rocha et al, 2002;Estelles et al, 2006), cannabinoid-exposed (Vela et al, 1998) and morphine-exposed offspring (Gagin et al, 1997) comparing to control animals. They showed increased drug-seeking behaviour in both self-administration test and condition place preference test (CPP).…”

Section: )mentioning

confidence: 99%

Effect of Amphetamine on Adult Male and Female Rats Prenatally Exposed to Methamphetamine

et al. 2014

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Abstract:The aim of the present study was to examine the cross-sensitization induced by prenatal methamphetamine (MA) exposure to adult amphetamine (AMP) treatment in male and female rats. Rat mothers received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male and female offspring (prenatally MA-or saline-exposed) were administered with AMP (5 mg/kg) or saline (1 ml/kg) in adulthood. Behaviour in unknown environment was examined in open field test (Laboras), active drug-seeking behaviour in conditioned place preference test (CPP), spatial memory in the Morris water maze (MWM), and levels of corticosterone (CORT) were analyzed by enzyme immunoassay (EIA). Our data demonstrate that in Laboras test, AMP treatment in adulthood increased general locomotion (time and distance travelled) regardless of the prenatal exposure and sex, while AMP increased exploratory activity (rearing) only in prenatally MA-exposed animals. AMP induced sensitization only in male rats, but not in females when tested drug-seeking behaviour in the CPP test. In the spatial memory MWM test, AMP worsened the performance only in Prague Medical Report / Vol. 115 (2014) No. 1-2, p. 43-59 females, but not in males. On the other hand, males swam faster after chronic AMP treatment regardless of the prenatal drug exposure. EIA analysis of CORT levels demonstrated higher level in females in all measurement settings. In males, prenatal MA exposure and chronic adult AMP treatment decreased CORT levels. Thus, our data demonstrated that adult AMP treatment affects behaviour of adult rats, their spatial memory and stress response in sex-specific manner. The effect is also influenced by prenatal drug exposure. 44)

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“…Se ha analizado el impacto de la EPC en animales en la posterior adicción a drogas mediante el modelo de Preferencia de Lugar Condicionada (PLC) que examina la sensibilidad al refuerzo de drogas, y el comportamiento de búsqueda de las mismas (Estelles et al, 2006;Gancarz, 2011;Mustaka & Kamenezky, 2006). Desde este modelo algunos estudios no han encontrado efectos de la EPC sobre las propiedades reforzantes de la cocaína o de otras drogas de abuso, ni sobre la búsqueda de la droga ni en ratas ni en ratones (Estelles et al, 2006;Heyser, Goodwin, Moody, & Spear, 1993;Heyser, Miller, Spear, & Spear, 1994;Malanga, Pejchal, y Kosofsky, 2007); mientras otros, han encontrado que únicamente las dosis bajas de EPC aumentan la sensibilidad a la cocaína, y otras drogas, 30mg/kg (Dow-Edwards et al, 2014), o 25 mg/kg (Estelles et al, 2006).…”

Section: Introductionunclassified

Cocaína prenatal y consumo de cocaína de ratones adultos jóvenes

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et al. 2017

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Prenatal cocaine exposure attenuates cocaine-induced odor preference in infant rats

Cited by 47 publications

References 31 publications

Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats?

Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats?

Effect of Amphetamine on Adult Male and Female Rats Prenatally Exposed to Methamphetamine

Cocaína prenatal y consumo de cocaína de ratones adultos jóvenes

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