Prenatal cytogenetic diagnosis: Amniotic cell culture versus chorionic villus sampling

Bell, Judith; Pearn, John; Smith, Arabella

doi:10.5694/j.1326-5377.1987.tb120122.x

Cited by 5 publications

(1 citation statement)

References 30 publications

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“…We observed that second trimester CVS is a safe and suitable option since none of these mothers reported fetal losses. Chorionic villus sampling has the advantage of the early diagnosis of haemophilia A, a shorter delay with results after the diagnostic procedure, and is, for some couples, a more socially and morally acceptable method of antenatal diagnosis [22]. Sampling efficiency and diagnostic reliability is as high as in midtrimester amniocentesis with fewer complications, provided the operator has the required training, skill and experience [20].…”

Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis of haemophilia A by chorionic villus sampling and cordocentesis: All India Institute of Medical Science experience

Ranjan¹,

Biswas²,

Kannan³

et al. 2006

Vox Sanguinis

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Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis of haemophilia A by chorionic villus sampling and cordocentesis: All India Institute of Medical Science experience

Ranjan¹,

Biswas²,

Kannan³

et al. 2006

Vox Sanguinis

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An overview of a 30-year experience with amniocentesis in a single tertiary medical center in Taiwan

Chang

Sung

et al. 2012

Taiwanese Journal of Obstetrics and Gynecology

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Cytogenetic Studies in Perinatal Death

Smith

Bannatyne

Russell

et al. 1990

Aust NZ J Obst Gynaeco

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Following tissue culture cytogenetic studies were performed on tissue obtained from 136 fetuses who died in the perinatal period (98 stillbirths and 38 neonatal deaths). The gestational age of the stillbirths was evenly distributed between 20 and 40 weeks (1 was 42 weeks) while 74% of the neonatal deaths were term babies. Analyzable metaphases were obtained in 45 stillbirth specimens (46%) and 32 neonatal specimens (84%). Abnormal karyotypes were identified in 7 of the stillbirths (15.5%) and 8 of the neonatal deaths (25%) and all these were from babies with congenital anomalies identified at autopsy. Time delays were crucial to the success of culture from stillbirths, but specimens obtained from neonatal deaths could be grown successfully up to 3 days after death. Generally the placenta was more viable than other tissues, including skin, cartilage and muscle. Whereas growth was obtained in 69% of fresh unexplained stillbirths, no tissue from the macerated stillbirths grew. This is a group which may have a high abnormality rate. We recommend that if fetal assessment during pregnancy suggests a compromised fetus and there are no maternal factors to account for this, an amniocentesis be performed.

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Prenatal cytogenetic diagnosis: Amniotic cell culture versus chorionic villus sampling

Cited by 5 publications

References 30 publications

Prenatal diagnosis of haemophilia A by chorionic villus sampling and cordocentesis: All India Institute of Medical Science experience

Prenatal diagnosis of haemophilia A by chorionic villus sampling and cordocentesis: All India Institute of Medical Science experience

An overview of a 30-year experience with amniocentesis in a single tertiary medical center in Taiwan

Cytogenetic Studies in Perinatal Death

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