Prenatal diagnosis of congenital cystic adenomatoid malformation of the lung by fetal lung biopsy

Murotsuki, Jun; Uehara, Shigeki; Okamura, Koji; Yajima, Akira; Murakami, Kazuhiro

doi:10.1002/pd.1970140722

Cited by 5 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the continuing advance in sonography and other imaging methodologies, the differential diagnosis of cystic lesions of the lung has become more precise 8 , 15 , 30 . Moreover, a needle biopsy of intra‐uterine foetal lung can be diagnostic 40 . The fluid and cells in the cyst can also be aspirated to assess carcinoembryonic agents, growth factors, chromosomal abnormalities, oncogenes, and others 11 .…”

Section: Discussionmentioning

confidence: 99%

“…8,15,30 Moreover, a needle biopsy of intra-uterine foetal lung can be diagnostic. 40 The fluid and cells in the cyst can also be aspirated to assess carcinoembryonic agents, growth factors, chromosomal abnormalities, oncogenes, and others. 11 However, a precise diagnosis of CCAM, especially whether there is GC or not, is still difficult, despite that CT can show lesions that are not apparent by other imaging studies.…”

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

The glandular component in congenital cystic adenomatoid malformation of the lung

Wang

Chen

1999

Respirology

View full text Add to dashboard Cite

Although severe congenital cystic changes (CCC) of the lung may be fatal, less severe forms may regress or vanish spontaneously. With recent advances in sonography, asymptomatic CCC are increasingly found. Whether all CCC should be promptly excised, or not, is uncertain. Congenital cystic changes conceptually are bronchopulmonary foregut malformations (BPFM) with a predilection for malignant degeneration. Among all BPFM, congenital cystic adenomatoid malformation (CCAM) is most common. We therefore searched for evidence of early malignant transformation in five surgically excised and three autopsy lungs with CCAM. By light microscopy, CCAM resembled poorly formed and dilated bronchi, bronchioles and respiratory air spaces. Four lungs had multiple nodular aggregates of mucus producing cells; the glandular component (GC). By scanning electron microscopy, GC appeared as multiple micropolyps, resembling neuroepithelial bodies. By transmission electron microscopy, GC had a surface proliferation of cells with granules of the mucous type and a basal increase in cells with owl-eyed neuroendocrine granules. The glandular component in CCAM appeared similar to the mucous cells in hyperplastic polyps of the colon and a type of mucus producing bronchioloalveolar carcinoma. Our findings support the hypothesis that CCAM is caused by dysregulated paracrine growth of mature cells and extracellular matrices and that GC could have the potential for malignant transformation. Further clinical and laboratory studies of BPFM are needed for the appropriate management of congenital cystic changes.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

The glandular component in congenital cystic adenomatoid malformation of the lung

Wang

Chen

1999

Respirology

View full text Add to dashboard Cite

show abstract

Congenital adenomatoid disease of the lung: prenatal diagnosis and perinatal management

et al. 1997

View full text Add to dashboard Cite

Prenatal ultrasonographic (US) detection of congenital adenomatoid malformation (CAM) was made in 18 fetuses at 17 - 36 weeks' gestation and managed in our institution during a 10-year period (1985-1994). The lesion was left-sided in 13 cases, right-sided in 4, and bilateral in 1. According to Stocker's classification, 12 cases were type I, 4 type II, and 2 type III. The prenatal course was followed with serial US examinations in 13 cases; the size of the lesion was stable in 8 and decreased in 5. Mediastinal shift was usually observed, and amniotic fluid volume was increased in 4 cases. One fetus was aborted. Six infants presented with respiratory distress syndrome and required neonatal surgery; delayed surgery was performed in 9 cases. Spontaneous regression of the lesion was observed on follow-up in 2 cases. Surgery consisted in lobectomy in 8 cases and segmentectomy in 6. The presence of fetal hydrops, type III lesions, and bilateral lung involvement are prenatal factors known to be associated with a poor prognosis. However, this series and a review of the literature suggest that caution should be observed with regard to the initial impression when counseling the parents regarding prognosis.

show abstract

Fetal lung abnormalities — What do they mean?

Pilling

1998

Clinical Radiology

View full text Add to dashboard Cite

Prenatal diagnosis of congenital cystic adenomatoid malformation of the lung by fetal lung biopsy

Cited by 5 publications

References 4 publications

The glandular component in congenital cystic adenomatoid malformation of the lung

The glandular component in congenital cystic adenomatoid malformation of the lung

Congenital adenomatoid disease of the lung: prenatal diagnosis and perinatal management

Fetal lung abnormalities — What do they mean?

Contact Info

Product

Resources

About