Prenatal diagnosis of congenital cytomegalovirus infection: prospective study of 237 pregnancies at risk

Liesnard, Corinne; Donner, Cathérine; Brancart, Françoise; Gosselin, Françoise; Delforge, Marie-Luce; Rodesch, Frédéric

doi:10.1016/s0029-7844(99)00657-2

Cited by 188 publications

(193 citation statements)

References 39 publications

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“…[12][13][14][15][16][17][18][19][20] We report important data concerning the rate of maternal-fetal transmission before and during pregnancy and confirm that symptomatic congenital CMV infections are hardly observed if maternal infection occurs after 14 WG. We found far fewer maternal symptoms than previously reported (21% in our cohort vs 68-73.5% in Revello et al 17,21,22 and 60% in Nigro et al 22 ).…”

Section: Discussionsupporting

confidence: 70%

“…Each subject included had maternal primary CMV infection assessed by serology analysis and precise gestational dating. Subjects were classified in different subgroups according to the time of maternal infection: preconceptional (2 months to 3 weeks before the date of conception), periconceptional (3 weeks before to 3 weeks after the date of conception), or first (3-14 weeks of gestation [WG]), second (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28) or third trimester of pregnancy (28 WG up to delivery). Subjects with imprecise date of maternal infection were excluded from the study.…”

Section: Methodsmentioning

confidence: 99%

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A series of 238 cytomegalovirus primary infections during pregnancy: description and outcome

et al. 2013

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Objective To analyze the outcome of maternal primary cytomegalovirus (CMV) infection.Methods Retrospective analysis of a cohort of 238 patients with maternal primary CMV infection detected at routine screening. The cases were managed with serial ultrasound (US) scans, and amniocentesis was performed in 36.1% of cases. All prenatal results were confirmed at birth. ResultsThe average age was 31.9 (18-44) years. Patients were symptomatic in 21% of cases. The rate of intrauterine transmission was 24.9%, and it was 8.8%, 19%, 30.6%, 34.1% and 40% in the preconceptional period, the periconceptional period, and the first, second and third trimesters of pregnancy, respectively (p = 0.025). There was a significantly higher risk of US abnormalities when maternal infection occurred during the preconceptional or periconceptional period and the first trimester compared with later (p < 0.001). Because of US abnormalities, pregnancy was terminated in 18 cases at the parents' request. Three infected newborns were symptomatic; all three cases were suspected at US before birth. We did not observe any symptomatic fetal infection when maternal infection occurred after 14 weeks of gestation. A number of clinically asymptomatic cases (5.5%) developed hearing loss. ConclusionThe rate of materno fetal transmission is linearly correlated to the gestational age at infection. No severe case of congenital infection was observed if maternal infection occurred after 14 weeks of gestation.

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Section: Discussionsupporting

confidence: 70%

Section: Methodsmentioning

confidence: 99%

A series of 238 cytomegalovirus primary infections during pregnancy: description and outcome

et al. 2013

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“…CMV was detected using the ELISA technique as was previously described [21,54]. Antibodies to CMV antigens were detected in the patient's serum using Diagnostic Automation ELISA Cytomegalovirus IgM Kit [55].…”

Section: Detection Of CMV Using Enzyme Linked Immunosorbent Assay (Elmentioning

confidence: 99%

“…Since then, it became a common practice to serologically test both mother and feotus during pregnancy [20,21].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Human Cytomegalovirus Infection among Human Immunodeficiency Virus Positive Women Receiving Antiretroviral Treatment at Federal Teaching Hospital Abakaliki, Ebonyi State, Nigeria

E¹,

Ogbu²

2017

J Biomedical Sci

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“…Of congenitally infected neonates, 90% are symptomless at birth, while 5-17% show some clinical manifestations. Among symptomatic newborns, 20% will die and 80% experience severe complications (14,15). Neonatal mortality rate is approximately 30% and 80% of live neonates have severe neurological outcomes (11).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Cytomegalovirus Antibodies and Primary Infection among Women and Infants in Iran: A Meta-Analysis

et al. 2016

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Background: Seroprevalence of Cytomegalovirus infection varies between 40% and 100% worldwide. Different studies carried out in Iran indicate this variation in this country. It is important to estimate the total infection prevalence using a reliable method such as meta-analysis in order to be applied by policymakers. This study aims to estimate the IgG and IgM seroprevalences of CMV infection among Iranian women and neonates. Method:We selected eligible articles for final meta-analysis by searching the national and international databases, excluding duplicates and irrelevant papers from primarily identified studies after abstract/full text review, implementing exclusion/inclusion criteria and quality assessment. Standard error of the prevalence was calculated according to binomial distribution formula. Based on the degree of heterogeneity, fixed or random effects models were applied for estimating the pooled prevalences. Results:In this study, 16 papers providing 20 evidences of CMV prevalence in Iran entered in the meta-analysis. CMV IgG and IgM seroprevalences as well as primary infection rate (95% confidence interval) among pregnant women were 92.8% (90.6 -94.9), 6.4% (2.8 -9.9) and 1.1% (0.7 -1.5) respectively. CMV IgM seroprevalence among neonates were 0.6% (0.09 -1.2), while CMV IgG and CMV IgM seroprevalences among non-pregnant women were 78.4% (70 -86.8) and 4.6% (1.5 -7.6) respectively. Conclusions:This meta-analysis showed that the prevalence of CMV infection among studied population is relatively high. Therefore, mortality, complications, anomalies and injuries among fetuses, neonates and immunocompromized patients can be partially related to the CMV infection.

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Prenatal diagnosis of congenital cytomegalovirus infection: prospective study of 237 pregnancies at risk

Cited by 188 publications

References 39 publications

A series of 238 cytomegalovirus primary infections during pregnancy: description and outcome

A series of 238 cytomegalovirus primary infections during pregnancy: description and outcome

Prevalence of Human Cytomegalovirus Infection among Human Immunodeficiency Virus Positive Women Receiving Antiretroviral Treatment at Federal Teaching Hospital Abakaliki, Ebonyi State, Nigeria

Seroprevalence of Cytomegalovirus Antibodies and Primary Infection among Women and Infants in Iran: A Meta-Analysis

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